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Inhibition of melanoma using a nanoceria-based prolonged oxygen-generating phototherapy hydrogel
Tumor hypoxic environment is an inevitable obstacle for photodynamic therapy (PDT) of melanoma. Herein, a multifunctional oxygen-generating hydrogel loaded with hyaluronic acid-chlorin e6 modified nanoceria and calcium peroxide (Gel-HCeC-CaO(2)) was developed for the phototherapy of melanoma. The th...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060878/ https://www.ncbi.nlm.nih.gov/pubmed/37007107 http://dx.doi.org/10.3389/fonc.2023.1126094 |
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author | Zhang, Lidong Liu, Xiaoguang Mao, Yinghua Rong, Shu Chen, Yonghong Qi, Yong Cai, Zhipeng Li, Hong |
author_facet | Zhang, Lidong Liu, Xiaoguang Mao, Yinghua Rong, Shu Chen, Yonghong Qi, Yong Cai, Zhipeng Li, Hong |
author_sort | Zhang, Lidong |
collection | PubMed |
description | Tumor hypoxic environment is an inevitable obstacle for photodynamic therapy (PDT) of melanoma. Herein, a multifunctional oxygen-generating hydrogel loaded with hyaluronic acid-chlorin e6 modified nanoceria and calcium peroxide (Gel-HCeC-CaO(2)) was developed for the phototherapy of melanoma. The thermo-sensitive hydrogel could act as a sustained drug delivery system to accumulate photosensitizers (chlorin e6, Ce6) around the tumor, followed by cellular uptake mediated by nanocarrier and hyaluronic acid (HA) targeting. The moderate sustained oxygen generation in the hydrogel was produced by the reaction of calcium peroxide (CaO(2)) with infiltrated H(2)O in the presence of catalase mimetic nanoceria. The developed Gel-HCeC-CaO(2) could efficiently alleviate the hypoxia microenvironment of tumors as indicated by the expression of hypoxia-inducible factor -1α (HIF-1α), meeting the “once injection, repeat irradiation” strategy and enhanced PDT efficacy. The prolonged oxygen-generating phototherapy hydrogel system provided a new strategy for tumor hypoxia alleviation and PDT. |
format | Online Article Text |
id | pubmed-10060878 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100608782023-03-31 Inhibition of melanoma using a nanoceria-based prolonged oxygen-generating phototherapy hydrogel Zhang, Lidong Liu, Xiaoguang Mao, Yinghua Rong, Shu Chen, Yonghong Qi, Yong Cai, Zhipeng Li, Hong Front Oncol Oncology Tumor hypoxic environment is an inevitable obstacle for photodynamic therapy (PDT) of melanoma. Herein, a multifunctional oxygen-generating hydrogel loaded with hyaluronic acid-chlorin e6 modified nanoceria and calcium peroxide (Gel-HCeC-CaO(2)) was developed for the phototherapy of melanoma. The thermo-sensitive hydrogel could act as a sustained drug delivery system to accumulate photosensitizers (chlorin e6, Ce6) around the tumor, followed by cellular uptake mediated by nanocarrier and hyaluronic acid (HA) targeting. The moderate sustained oxygen generation in the hydrogel was produced by the reaction of calcium peroxide (CaO(2)) with infiltrated H(2)O in the presence of catalase mimetic nanoceria. The developed Gel-HCeC-CaO(2) could efficiently alleviate the hypoxia microenvironment of tumors as indicated by the expression of hypoxia-inducible factor -1α (HIF-1α), meeting the “once injection, repeat irradiation” strategy and enhanced PDT efficacy. The prolonged oxygen-generating phototherapy hydrogel system provided a new strategy for tumor hypoxia alleviation and PDT. Frontiers Media S.A. 2023-03-16 /pmc/articles/PMC10060878/ /pubmed/37007107 http://dx.doi.org/10.3389/fonc.2023.1126094 Text en Copyright © 2023 Zhang, Liu, Mao, Rong, Chen, Qi, Cai and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Zhang, Lidong Liu, Xiaoguang Mao, Yinghua Rong, Shu Chen, Yonghong Qi, Yong Cai, Zhipeng Li, Hong Inhibition of melanoma using a nanoceria-based prolonged oxygen-generating phototherapy hydrogel |
title | Inhibition of melanoma using a nanoceria-based prolonged oxygen-generating phototherapy hydrogel |
title_full | Inhibition of melanoma using a nanoceria-based prolonged oxygen-generating phototherapy hydrogel |
title_fullStr | Inhibition of melanoma using a nanoceria-based prolonged oxygen-generating phototherapy hydrogel |
title_full_unstemmed | Inhibition of melanoma using a nanoceria-based prolonged oxygen-generating phototherapy hydrogel |
title_short | Inhibition of melanoma using a nanoceria-based prolonged oxygen-generating phototherapy hydrogel |
title_sort | inhibition of melanoma using a nanoceria-based prolonged oxygen-generating phototherapy hydrogel |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060878/ https://www.ncbi.nlm.nih.gov/pubmed/37007107 http://dx.doi.org/10.3389/fonc.2023.1126094 |
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