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Inhibition of melanoma using a nanoceria-based prolonged oxygen-generating phototherapy hydrogel

Tumor hypoxic environment is an inevitable obstacle for photodynamic therapy (PDT) of melanoma. Herein, a multifunctional oxygen-generating hydrogel loaded with hyaluronic acid-chlorin e6 modified nanoceria and calcium peroxide (Gel-HCeC-CaO(2)) was developed for the phototherapy of melanoma. The th...

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Autores principales: Zhang, Lidong, Liu, Xiaoguang, Mao, Yinghua, Rong, Shu, Chen, Yonghong, Qi, Yong, Cai, Zhipeng, Li, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060878/
https://www.ncbi.nlm.nih.gov/pubmed/37007107
http://dx.doi.org/10.3389/fonc.2023.1126094
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author Zhang, Lidong
Liu, Xiaoguang
Mao, Yinghua
Rong, Shu
Chen, Yonghong
Qi, Yong
Cai, Zhipeng
Li, Hong
author_facet Zhang, Lidong
Liu, Xiaoguang
Mao, Yinghua
Rong, Shu
Chen, Yonghong
Qi, Yong
Cai, Zhipeng
Li, Hong
author_sort Zhang, Lidong
collection PubMed
description Tumor hypoxic environment is an inevitable obstacle for photodynamic therapy (PDT) of melanoma. Herein, a multifunctional oxygen-generating hydrogel loaded with hyaluronic acid-chlorin e6 modified nanoceria and calcium peroxide (Gel-HCeC-CaO(2)) was developed for the phototherapy of melanoma. The thermo-sensitive hydrogel could act as a sustained drug delivery system to accumulate photosensitizers (chlorin e6, Ce6) around the tumor, followed by cellular uptake mediated by nanocarrier and hyaluronic acid (HA) targeting. The moderate sustained oxygen generation in the hydrogel was produced by the reaction of calcium peroxide (CaO(2)) with infiltrated H(2)O in the presence of catalase mimetic nanoceria. The developed Gel-HCeC-CaO(2) could efficiently alleviate the hypoxia microenvironment of tumors as indicated by the expression of hypoxia-inducible factor -1α (HIF-1α), meeting the “once injection, repeat irradiation” strategy and enhanced PDT efficacy. The prolonged oxygen-generating phototherapy hydrogel system provided a new strategy for tumor hypoxia alleviation and PDT.
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spelling pubmed-100608782023-03-31 Inhibition of melanoma using a nanoceria-based prolonged oxygen-generating phototherapy hydrogel Zhang, Lidong Liu, Xiaoguang Mao, Yinghua Rong, Shu Chen, Yonghong Qi, Yong Cai, Zhipeng Li, Hong Front Oncol Oncology Tumor hypoxic environment is an inevitable obstacle for photodynamic therapy (PDT) of melanoma. Herein, a multifunctional oxygen-generating hydrogel loaded with hyaluronic acid-chlorin e6 modified nanoceria and calcium peroxide (Gel-HCeC-CaO(2)) was developed for the phototherapy of melanoma. The thermo-sensitive hydrogel could act as a sustained drug delivery system to accumulate photosensitizers (chlorin e6, Ce6) around the tumor, followed by cellular uptake mediated by nanocarrier and hyaluronic acid (HA) targeting. The moderate sustained oxygen generation in the hydrogel was produced by the reaction of calcium peroxide (CaO(2)) with infiltrated H(2)O in the presence of catalase mimetic nanoceria. The developed Gel-HCeC-CaO(2) could efficiently alleviate the hypoxia microenvironment of tumors as indicated by the expression of hypoxia-inducible factor -1α (HIF-1α), meeting the “once injection, repeat irradiation” strategy and enhanced PDT efficacy. The prolonged oxygen-generating phototherapy hydrogel system provided a new strategy for tumor hypoxia alleviation and PDT. Frontiers Media S.A. 2023-03-16 /pmc/articles/PMC10060878/ /pubmed/37007107 http://dx.doi.org/10.3389/fonc.2023.1126094 Text en Copyright © 2023 Zhang, Liu, Mao, Rong, Chen, Qi, Cai and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhang, Lidong
Liu, Xiaoguang
Mao, Yinghua
Rong, Shu
Chen, Yonghong
Qi, Yong
Cai, Zhipeng
Li, Hong
Inhibition of melanoma using a nanoceria-based prolonged oxygen-generating phototherapy hydrogel
title Inhibition of melanoma using a nanoceria-based prolonged oxygen-generating phototherapy hydrogel
title_full Inhibition of melanoma using a nanoceria-based prolonged oxygen-generating phototherapy hydrogel
title_fullStr Inhibition of melanoma using a nanoceria-based prolonged oxygen-generating phototherapy hydrogel
title_full_unstemmed Inhibition of melanoma using a nanoceria-based prolonged oxygen-generating phototherapy hydrogel
title_short Inhibition of melanoma using a nanoceria-based prolonged oxygen-generating phototherapy hydrogel
title_sort inhibition of melanoma using a nanoceria-based prolonged oxygen-generating phototherapy hydrogel
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060878/
https://www.ncbi.nlm.nih.gov/pubmed/37007107
http://dx.doi.org/10.3389/fonc.2023.1126094
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