Cargando…

Impact of hypertensive disorders of pregnancy on short- and long-term outcomes of pregnancy-associated hemorrhagic stroke

BACKGROUND AND PURPOSE: Though hypertension disorders of pregnancy (HDP) are recognized as independent pregnancy-associated stroke risk factors, few studies have considered their impact on stroke prognosis. Therefore, we intended to evaluate the impact of HDP on short- and long-term outcomes of preg...

Descripción completa

Detalles Bibliográficos
Autores principales: Fang, Mei, Wang, Jiayan, Wang, Zexu, Chen, Yuqi, Xu, Wei, Tao, Chuanyuan, Ma, Lu, You, Chao, Hu, Xin, Xia, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060960/
https://www.ncbi.nlm.nih.gov/pubmed/37006493
http://dx.doi.org/10.3389/fneur.2023.1097183
_version_ 1785017196012896256
author Fang, Mei
Wang, Jiayan
Wang, Zexu
Chen, Yuqi
Xu, Wei
Tao, Chuanyuan
Ma, Lu
You, Chao
Hu, Xin
Xia, Fan
author_facet Fang, Mei
Wang, Jiayan
Wang, Zexu
Chen, Yuqi
Xu, Wei
Tao, Chuanyuan
Ma, Lu
You, Chao
Hu, Xin
Xia, Fan
author_sort Fang, Mei
collection PubMed
description BACKGROUND AND PURPOSE: Though hypertension disorders of pregnancy (HDP) are recognized as independent pregnancy-associated stroke risk factors, few studies have considered their impact on stroke prognosis. Therefore, we intended to evaluate the impact of HDP on short- and long-term outcomes of pregnancy-associated hemorrhagic stroke (HS). METHODS: We conducted a retrospective analysis of patients admitted to our hospital from May 2009 to December 2021 with a diagnosis of pregnancy-associated HS. After dividing patients into two groups by the presence of a diagnosis of HDP or not, the short- (at the time of discharge) and long-term (after discharge follow-up) outcomes were compared by mRS (modified Rankin Scale) scores, and poor functional outcome defined as mRS > 2. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were reported. RESULTS: Twenty-two HDP and 72 non-HDP pregnancy-associated HS patients were enrolled and follow-up after 4.7 ± 3.6 years. There was no significant difference between the two groups regarding short-term outcomes, but patients with HDP were more likely to reach poor functional outcomes at long-term follow-up (aOR = 4.47, 95% CI = 1.28–15.67, p = 0.019). CONCLUSIONS: In this retrospective study, women with hypertension disorders of pregnancy did not show worse short-term outcomes of pregnancy-associated hemorrhagic stroke compared to those without but had poorer long-term functional outcomes. This underlines the importance of prevention, recognition, and treatment of hypertension disorders in these women.
format Online
Article
Text
id pubmed-10060960
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-100609602023-03-31 Impact of hypertensive disorders of pregnancy on short- and long-term outcomes of pregnancy-associated hemorrhagic stroke Fang, Mei Wang, Jiayan Wang, Zexu Chen, Yuqi Xu, Wei Tao, Chuanyuan Ma, Lu You, Chao Hu, Xin Xia, Fan Front Neurol Neurology BACKGROUND AND PURPOSE: Though hypertension disorders of pregnancy (HDP) are recognized as independent pregnancy-associated stroke risk factors, few studies have considered their impact on stroke prognosis. Therefore, we intended to evaluate the impact of HDP on short- and long-term outcomes of pregnancy-associated hemorrhagic stroke (HS). METHODS: We conducted a retrospective analysis of patients admitted to our hospital from May 2009 to December 2021 with a diagnosis of pregnancy-associated HS. After dividing patients into two groups by the presence of a diagnosis of HDP or not, the short- (at the time of discharge) and long-term (after discharge follow-up) outcomes were compared by mRS (modified Rankin Scale) scores, and poor functional outcome defined as mRS > 2. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were reported. RESULTS: Twenty-two HDP and 72 non-HDP pregnancy-associated HS patients were enrolled and follow-up after 4.7 ± 3.6 years. There was no significant difference between the two groups regarding short-term outcomes, but patients with HDP were more likely to reach poor functional outcomes at long-term follow-up (aOR = 4.47, 95% CI = 1.28–15.67, p = 0.019). CONCLUSIONS: In this retrospective study, women with hypertension disorders of pregnancy did not show worse short-term outcomes of pregnancy-associated hemorrhagic stroke compared to those without but had poorer long-term functional outcomes. This underlines the importance of prevention, recognition, and treatment of hypertension disorders in these women. Frontiers Media S.A. 2023-03-16 /pmc/articles/PMC10060960/ /pubmed/37006493 http://dx.doi.org/10.3389/fneur.2023.1097183 Text en Copyright © 2023 Fang, Wang, Wang, Chen, Xu, Tao, Ma, You, Hu and Xia. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Fang, Mei
Wang, Jiayan
Wang, Zexu
Chen, Yuqi
Xu, Wei
Tao, Chuanyuan
Ma, Lu
You, Chao
Hu, Xin
Xia, Fan
Impact of hypertensive disorders of pregnancy on short- and long-term outcomes of pregnancy-associated hemorrhagic stroke
title Impact of hypertensive disorders of pregnancy on short- and long-term outcomes of pregnancy-associated hemorrhagic stroke
title_full Impact of hypertensive disorders of pregnancy on short- and long-term outcomes of pregnancy-associated hemorrhagic stroke
title_fullStr Impact of hypertensive disorders of pregnancy on short- and long-term outcomes of pregnancy-associated hemorrhagic stroke
title_full_unstemmed Impact of hypertensive disorders of pregnancy on short- and long-term outcomes of pregnancy-associated hemorrhagic stroke
title_short Impact of hypertensive disorders of pregnancy on short- and long-term outcomes of pregnancy-associated hemorrhagic stroke
title_sort impact of hypertensive disorders of pregnancy on short- and long-term outcomes of pregnancy-associated hemorrhagic stroke
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060960/
https://www.ncbi.nlm.nih.gov/pubmed/37006493
http://dx.doi.org/10.3389/fneur.2023.1097183
work_keys_str_mv AT fangmei impactofhypertensivedisordersofpregnancyonshortandlongtermoutcomesofpregnancyassociatedhemorrhagicstroke
AT wangjiayan impactofhypertensivedisordersofpregnancyonshortandlongtermoutcomesofpregnancyassociatedhemorrhagicstroke
AT wangzexu impactofhypertensivedisordersofpregnancyonshortandlongtermoutcomesofpregnancyassociatedhemorrhagicstroke
AT chenyuqi impactofhypertensivedisordersofpregnancyonshortandlongtermoutcomesofpregnancyassociatedhemorrhagicstroke
AT xuwei impactofhypertensivedisordersofpregnancyonshortandlongtermoutcomesofpregnancyassociatedhemorrhagicstroke
AT taochuanyuan impactofhypertensivedisordersofpregnancyonshortandlongtermoutcomesofpregnancyassociatedhemorrhagicstroke
AT malu impactofhypertensivedisordersofpregnancyonshortandlongtermoutcomesofpregnancyassociatedhemorrhagicstroke
AT youchao impactofhypertensivedisordersofpregnancyonshortandlongtermoutcomesofpregnancyassociatedhemorrhagicstroke
AT huxin impactofhypertensivedisordersofpregnancyonshortandlongtermoutcomesofpregnancyassociatedhemorrhagicstroke
AT xiafan impactofhypertensivedisordersofpregnancyonshortandlongtermoutcomesofpregnancyassociatedhemorrhagicstroke