Cargando…

A chemokine network of T cell exhaustion and metabolic reprogramming in renal cell carcinoma

Renal cell carcinoma (RCC) is frequently infiltrated by immune cells, a process which is governed by chemokines. CD8(+) T cells in the RCC tumor microenvironment (TME) may be exhausted which most likely influence therapy response and survival. The aim of this study was to evaluate chemokine-driven T...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pichler, Renate, Siska, Peter J., Tymoszuk, Piotr, Martowicz, Agnieszka, Untergasser, Gerold, Mayr, Roman, Weber, Florian, Seeber, Andreas, Kocher, Florian, Barth, Dominik A., Pichler, Martin, Thurnher, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060976/ https://www.ncbi.nlm.nih.gov/pubmed/37006314 http://dx.doi.org/10.3389/fimmu.2023.1095195

Ejemplares similares

CXCR3 Expression Is Associated with Advanced Tumor Stage and Grade Influencing Survival after Surgery of Localised Renal Cell Carcinoma
por: Lindner, Andrea Katharina, et al.
Publicado: (2023)

Sex hormones influence survival of patients with metastatic urothelial carcinoma undergoing immune checkpoint therapy
por: Lindner, Andrea Katharina, et al.
Publicado: (2023)

Targeting strategies in the treatment of fumarate hydratase deficient renal cell carcinoma
por: Lindner, Andrea Katharina, et al.
Publicado: (2022)

Optimization of postoperative surveillance protocols in upper tract urothelial cancer: A retrospective cohort study
por: Lindner, Andrea Katharina, et al.
Publicado: (2023)

Phenotype-dependent effects of EpCAM expression on growth and invasion of human breast cancer cell lines
por: Martowicz, Agnieszka, et al.
Publicado: (2012)

Soluble EpCAM levels in ascites correlate with positive cytology and neutralize catumaxomab activity in vitro
por: Seeber, Andreas, et al.
Publicado: (2015)

Lynch Syndrome: Its Impact on Urothelial Carcinoma
por: Lindner, Andrea Katharina, et al.
Publicado: (2021)

Multi-omic Characterization of Pancreatic Ductal Adenocarcinoma Relates CXCR4 mRNA Expression Levels to Potential Clinical Targets
por: Kocher, Florian, et al.
Publicado: (2022)

EpCAM overexpression prolongs proliferative capacity of primary human breast epithelial cells and supports hyperplastic growth
por: Martowicz, Agnieszka, et al.
Publicado: (2013)

High indoleamine-2,3-dioxygenase 1 (IDO) activity is linked to primary resistance to immunotherapy in non-small cell lung cancer (NSCLC)
por: Kocher, Florian, et al.
Publicado: (2021)

Biomarkers of evasive resistance predict disease progression in cancer patients treated with antiangiogenic therapies
por: Pircher, Andreas, et al.
Publicado: (2016)

Benefit of second-line therapy for advanced esophageal squamous cell carcinoma: a tri-center propensity score analysis
por: Müller, Moritz, et al.
Publicado: (2021)

Expression of ADAM Proteases in Bladder Cancer Patients with BCG Failure: A Pilot Study
por: Pichler, Renate, et al.
Publicado: (2021)

CMTM6 expression as a potential biomarker for immunotherapy in metastatic renal cell carcinoma
por: Tulchiner, Gennadi, et al.
Publicado: (2021)

High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer
por: Salcher, Stefan, et al.
Publicado: (2022)

Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy
por: Bulliard, Yannick, et al.
Publicado: (2023)

High economic burden of immunotherapy underlines the need of predictive biomarkers for the individual therapy algorithm in metastatic bladder cancer
por: Pichler, Renate, et al.
Publicado: (2018)

The Road Less Taken: Less Appreciated Pathways for Manipulating CD8(+) T Cell Exhaustion
por: Pichler, Andrea C., et al.
Publicado: (2022)

Long Non-Coding RNA PANTR1 is Associated with Poor Prognosis and Influences Angiogenesis and Apoptosis in Clear-Cell Renal Cell Cancer
por: Seles, Maximilian, et al.
Publicado: (2020)

Sex-specific hormone changes during immunotherapy and its influence on survival in metastatic renal cell carcinoma
por: Tulchiner, Gennadi, et al.
Publicado: (2021)

Intratumoral Th2 predisposition combines with an increased Th1 functional phenotype in clinical response to intravesical BCG in bladder cancer
por: Pichler, Renate, et al.
Publicado: (2016)

Renal Cell Carcinoma with Sarcomatoid Features: Finally New Therapeutic Hope?
por: Pichler, Renate, et al.
Publicado: (2019)

The Biology of Classic Hairy Cell Leukemia
por: Bohn, Jan-Paul, et al.
Publicado: (2021)

MiR-200c-3p Modulates Cisplatin Resistance in Biliary Tract Cancer by ZEB1-Independent Mechanisms
por: Posch, Florian, et al.
Publicado: (2021)

Editorial: Immune checkpoint inhibitors in renal cell carcinoma
por: Tykodi, Scott S., et al.
Publicado: (2023)

Novel concepts of antiangiogenic therapies in metastatic renal cell cancer
por: Pichler, Renate, et al.
Publicado: (2017)

Non-Coding RNAs and SARS-Related Coronaviruses
por: Henzinger, Hanna, et al.
Publicado: (2020)

Involvement of Long Non-Coding RNAs in Glucose Metabolism in Cancer
por: Balihodzic, Amar, et al.
Publicado: (2021)

Current Concepts of Non-Coding RNAs in the Pathogenesis of Non-Clear Cell Renal Cell Carcinoma
por: Barth, Dominik A., et al.
Publicado: (2019)

PBRM1 mutations might render a subtype of biliary tract cancers sensitive to drugs targeting the DNA damage repair system
por: Zimmer, Kai, et al.
Publicado: (2023)

Synergies of Targeting Tumor Angiogenesis and Immune Checkpoints in Non-Small Cell Lung Cancer and Renal Cell Cancer: From Basic Concepts to Clinical Reality
por: Pircher, Andreas, et al.
Publicado: (2017)

Biliary tract cancer stem cells - translational options and challenges
por: Mayr, Christian, et al.
Publicado: (2017)

Targeting the Tumor Microenvironment in Renal Cell Cancer Biology and Therapy
por: Heidegger, Isabel, et al.
Publicado: (2019)

Isochromosome 12p Formation Regulates Vitamin D Metabolism in Testicular Cancer
por: Törzsök, Peter, et al.
Publicado: (2023)

Spliced XBP1 Levels Determine Sensitivity of Multiple Myeloma Cells to Proteasome Inhibitor Bortezomib Independent of the Unfolded Protein Response Mediator GRP78
por: Borjan, Bojana, et al.
Publicado: (2020)

The Prognostic Impact of Comorbidities in Patients with De-Novo Diffuse Large B-Cell Lymphoma Treated with R-CHOP Immunochemotherapy in Curative Intent
por: Kocher, Florian, et al.
Publicado: (2020)

Circulating Non-coding RNAs in Renal Cell Carcinoma—Pathogenesis and Potential Implications as Clinical Biomarkers
por: Barth, Dominik A., et al.
Publicado: (2020)

Immune Checkpoint Inhibitors in Uro-Oncology: Urgent Call for Biomarkers
por: Pichler, Renate
Publicado: (2020)

Metabolic characterization of directly reprogrammed renal tubular epithelial cells (iRECs)
por: Lagies, Simon, et al.
Publicado: (2018)

High IDO‐1 expression in tumor endothelial cells is associated with response to immunotherapy in metastatic renal cell carcinoma
por: Seeber, Andreas, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_napm6to3d9fa1ovlpc19n7eahc