Cargando…

Characterization of heterogeneous metabolism in hepatocellular carcinoma identifies new therapeutic target and treatment strategy

BACKGROUND: Metabolic reprogramming is a well-known hallmark of cancer. Systematical identification of clinically relevant metabolic subtypes of Hepatocellular carcinoma (HCC) is critical to understand tumor heterogeneity and develop efficient treatment strategies. METHODS: We performed an integrati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Jiabin, Zeng, Liangtang, Chen, Ruiwan, Zheng, Shangyou, Zhou, Yu, Chen, Rufu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060979/ https://www.ncbi.nlm.nih.gov/pubmed/37006288 http://dx.doi.org/10.3389/fimmu.2023.1076587

Ejemplares similares

Leveraging Tumor Microenvironment Infiltration in Pancreatic Cancer to Identify Gene Signatures Related to Prognosis and Immunotherapy Response
por: Yang, Jiabin, et al.
Publicado: (2023)

Single-cell RNA sequencing reveals spatiotemporal heterogeneity and malignant progression in pancreatic neuroendocrine tumor
por: Zhou, Yu, et al.
Publicado: (2021)

Metabolic rearrangements and intratumoral heterogeneity for immune response in hepatocellular carcinoma
por: Xu, Fei-Qi, et al.
Publicado: (2023)

Characterization of chromatin regulators identified prognosis and heterogeneity in hepatocellular carcinoma
por: Dai, Yin-wei, et al.
Publicado: (2022)

LncRNA HOTAIR epigenetically suppresses miR-122 expression in hepatocellular carcinoma via DNA methylation
por: Cheng, Di, et al.
Publicado: (2018)

The Heterogeneity of Immune Cell Infiltration Landscape and Its Immunotherapeutic Implications in Hepatocellular Carcinoma
por: Guo, Yuanyuan, et al.
Publicado: (2022)

Strategies to Improve the Antitumor Effect of Immunotherapy for Hepatocellular Carcinoma
por: Xing, Rui, et al.
Publicado: (2021)

Immunotherapy of hepatocellular carcinoma: recent progress and new strategy
por: Li, Jiarui, et al.
Publicado: (2023)

A novel gene signature for prognosis prediction and chemotherapy response in patients with pancreatic cancer
por: Lin, Hongcao, et al.
Publicado: (2021)

Identifying potential pharmacological targets and mechanisms of vitamin D for hepatocellular carcinoma and COVID-19
por: Huang, Yongbiao, et al.
Publicado: (2022)

Cuproptosis-Related Risk Score Predicts Prognosis and Characterizes the Tumor Microenvironment in Hepatocellular Carcinoma
por: Zhang, Zhen, et al.
Publicado: (2022)

PANoptosis-based molecular subtyping and HPAN-index predicts therapeutic response and survival in hepatocellular carcinoma
por: Song, Fei, et al.
Publicado: (2023)

Colorectal Cancer-Infiltrating Regulatory T Cells: Functional Heterogeneity, Metabolic Adaptation, and Therapeutic Targeting
por: Aristin Revilla, Sonia, et al.
Publicado: (2022)

Immune and non-immune cell subtypes identify novel targets for prognostic and therapeutic strategy: A study based on intratumoral heterogenicity analysis of multicenter scRNA-seq datasets in lung adenocarcinoma
por: Fan, Tianyu, et al.
Publicado: (2022)

Functional proteomics identify mannitol metabolism in serum resistance and therapeutic implications in Vibrio alginolyticus
por: Kou, Tian-shun, et al.
Publicado: (2022)

Peripheral B-Cell Immunophenotyping Identifies Heterogeneity in IgG4-Related Disease
por: Li, Jieqiong, et al.
Publicado: (2021)

Identification and validation of a tyrosine metabolism-related prognostic prediction model and characterization of the tumor microenvironment infiltration in hepatocellular carcinoma
por: Zhou, Yangying, et al.
Publicado: (2022)

CD8+ T cell trajectory subtypes decode tumor heterogeneity and provide treatment recommendations for hepatocellular carcinoma
por: Liu, Long, et al.
Publicado: (2022)

In Situ Vaccination as a Strategy to Modulate the Immune Microenvironment of Hepatocellular Carcinoma
por: Lurje, Isabella, et al.
Publicado: (2021)

Characterizing hepatocellular carcinoma stem markers and their corresponding susceptibility to NK-cell based immunotherapy
por: Chiang, Jason, et al.
Publicado: (2023)

A Novel hepatocellular carcinoma specific hypoxic related signature for predicting prognosis and therapeutic responses
por: Cai, Guangzhen, et al.
Publicado: (2022)

An EGFR L858R mutation identified in 1862 Chinese NSCLC patients can be a promising neoantigen vaccine therapeutic strategy
por: Lin, Jing, et al.
Publicado: (2022)

Immunological Classification of Pancreatic Carcinomas to Identify Immune Index and Provide a Strategy for Patient Stratification
por: Chen, Yi, et al.
Publicado: (2022)

Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies
por: Huang, Boyuan, et al.
Publicado: (2023)

Mutant KRAS Mediates circARFGEF2 Biogenesis to Promote Lymphatic Metastasis of Pancreatic Ductal Adenocarcinoma
por: Kong, Yao, et al.
Publicado: (2023)

Necroptosis throws novel insights on patient classification and treatment strategies for hepatocellular carcinoma
por: Hu, Bowen, et al.
Publicado: (2022)

Comprehensive Analysis Identifies and Validates the Tumor Microenvironment Subtypes to Predict Anti-Tumor Therapy Efficacy in Hepatocellular Carcinoma
por: Zhang, Haohan, et al.
Publicado: (2022)

Extracellular vesicle-mediated heterogeneous communication between cancer and the lymphatic system facilitates lymphatic metastasis
por: Chen, Changhao, et al.
Publicado: (2023)

Crosstalk Between Metabolism and Immune Activity Reveals Four Subtypes With Therapeutic Implications in Clear Cell Renal Cell Carcinoma
por: Wang, Yi, et al.
Publicado: (2022)

Editorial: Macrophage immunity and metabolism in cancer: Novel diagnostic and therapeutic strategies
por: Leavenworth, Jianmei W., et al.
Publicado: (2022)

Targeted Next-Generation Sequencing Combined With Circulating-Free DNA Deciphers Spatial Heterogeneity of Resected Multifocal Hepatocellular Carcinoma
por: Lin, Jianzhen, et al.
Publicado: (2021)

Comprehensive analysis of cuproptosis-related lncRNAs for prognostic significance and immune microenvironment characterization in hepatocellular carcinoma
por: Li, Duguang, et al.
Publicado: (2023)

Copper and cuproptosis-related genes in hepatocellular carcinoma: therapeutic biomarkers targeting tumor immune microenvironment and immune checkpoints
por: Wang, Xiaoqiang, et al.
Publicado: (2023)

Commentary: Copper and cuproptosis-related genes in hepatocellular carcinoma: therapeutic biomarkers targeting tumor immune microenvironment and immune checkpoints
por: Xu, Fangshi, et al.
Publicado: (2023)

Characterization of immune features and immunotherapy response in subtypes of hepatocellular carcinoma based on mitophagy
por: Wang, Yanan, et al.
Publicado: (2022)

Characterization of prognostic value and immunological roles of RAB22A in hepatocellular carcinoma
por: Wen, Fukai, et al.
Publicado: (2023)

Combinatory local ablation and immunotherapies for hepatocellular carcinoma: Rationale, efficacy, and perspective
por: Chen, Shuling, et al.
Publicado: (2022)

A Risk Model Developed Based on Necroptosis Predicts Overall Survival for Hepatocellular Carcinoma and Identification of Possible Therapeutic Drugs
por: Li, Zedong, et al.
Publicado: (2022)

Inhibition of glutamine metabolism counteracts pancreatic cancer stem cell features and sensitizes cells to radiotherapy
por: Li, Doudou, et al.
Publicado: (2015)

Tumor microenvironment-mediated immune evasion in hepatocellular carcinoma
por: Chen, Chen, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_715o6jqdn7758bqs4p12kouba5