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Combined effects of EMP and RF field on emotional behavior in mice
BACKGROUND: Recently, concerns about the combined effects of electromagnetic field (EMF) in daily living and occupational environment are rapidly growing. METHODS: In this study, we investigated the combined effects of 1-week exposure to electromagnetic pulse (EMP) at 650 kV/m for 1,000 pulses and 4...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061096/ https://www.ncbi.nlm.nih.gov/pubmed/37006533 http://dx.doi.org/10.3389/fpubh.2023.1087161 |
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author | Qin, Tongzhou Liu, Liyuan Wang, Xing Guo, Ling Lin, Jiajin Du, Junze Xue, Yizhe Lai, Panpan Jing, Yuntao Ding, Guirong |
author_facet | Qin, Tongzhou Liu, Liyuan Wang, Xing Guo, Ling Lin, Jiajin Du, Junze Xue, Yizhe Lai, Panpan Jing, Yuntao Ding, Guirong |
author_sort | Qin, Tongzhou |
collection | PubMed |
description | BACKGROUND: Recently, concerns about the combined effects of electromagnetic field (EMF) in daily living and occupational environment are rapidly growing. METHODS: In this study, we investigated the combined effects of 1-week exposure to electromagnetic pulse (EMP) at 650 kV/m for 1,000 pulses and 4.9 GHz radiofrequency (RF) at 50 W/m(2) for 1 h/d in male mice. Open field test, tail suspension test and Y-maze were applied to evaluate anxiety, depression-like behaviors and spatial memory ability, respectively. RESULTS: It was found that compared with Sham group, combined exposure to EMP and RF induced anxiety-like behavior, increased the level of serum S100B and decreased the level of serum 5-HT. The results of quantitative proteomic and KEGG analysis showed that the differentially expressed proteins in hippocampus were enriched in Glutamatergic and GABAergic synapse after combined exposure group, which were verified by western blot. In addition, an obvious histological alteration and autophagy-associated cell death were observed in amygdala instead of hippocampus after combined exposure to EMP and 4.9 GHz RF. CONCLUSION: Combined exposure to EMP and 4.9 GHz RF could induce emotional behavior alteration, which might be associated with Glutamatergic and GABAergic synapse system of hippocampus and autophagy in amygdala. |
format | Online Article Text |
id | pubmed-10061096 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100610962023-03-31 Combined effects of EMP and RF field on emotional behavior in mice Qin, Tongzhou Liu, Liyuan Wang, Xing Guo, Ling Lin, Jiajin Du, Junze Xue, Yizhe Lai, Panpan Jing, Yuntao Ding, Guirong Front Public Health Public Health BACKGROUND: Recently, concerns about the combined effects of electromagnetic field (EMF) in daily living and occupational environment are rapidly growing. METHODS: In this study, we investigated the combined effects of 1-week exposure to electromagnetic pulse (EMP) at 650 kV/m for 1,000 pulses and 4.9 GHz radiofrequency (RF) at 50 W/m(2) for 1 h/d in male mice. Open field test, tail suspension test and Y-maze were applied to evaluate anxiety, depression-like behaviors and spatial memory ability, respectively. RESULTS: It was found that compared with Sham group, combined exposure to EMP and RF induced anxiety-like behavior, increased the level of serum S100B and decreased the level of serum 5-HT. The results of quantitative proteomic and KEGG analysis showed that the differentially expressed proteins in hippocampus were enriched in Glutamatergic and GABAergic synapse after combined exposure group, which were verified by western blot. In addition, an obvious histological alteration and autophagy-associated cell death were observed in amygdala instead of hippocampus after combined exposure to EMP and 4.9 GHz RF. CONCLUSION: Combined exposure to EMP and 4.9 GHz RF could induce emotional behavior alteration, which might be associated with Glutamatergic and GABAergic synapse system of hippocampus and autophagy in amygdala. Frontiers Media S.A. 2023-03-16 /pmc/articles/PMC10061096/ /pubmed/37006533 http://dx.doi.org/10.3389/fpubh.2023.1087161 Text en Copyright © 2023 Qin, Liu, Wang, Guo, Lin, Du, Xue, Lai, Jing and Ding. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Qin, Tongzhou Liu, Liyuan Wang, Xing Guo, Ling Lin, Jiajin Du, Junze Xue, Yizhe Lai, Panpan Jing, Yuntao Ding, Guirong Combined effects of EMP and RF field on emotional behavior in mice |
title | Combined effects of EMP and RF field on emotional behavior in mice |
title_full | Combined effects of EMP and RF field on emotional behavior in mice |
title_fullStr | Combined effects of EMP and RF field on emotional behavior in mice |
title_full_unstemmed | Combined effects of EMP and RF field on emotional behavior in mice |
title_short | Combined effects of EMP and RF field on emotional behavior in mice |
title_sort | combined effects of emp and rf field on emotional behavior in mice |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061096/ https://www.ncbi.nlm.nih.gov/pubmed/37006533 http://dx.doi.org/10.3389/fpubh.2023.1087161 |
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