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Ultrasound features for prediction of long-term outcomes of women with primary breast cancer <20 mm

BACKGROUND: Some women die despite the favorable prognosis of small breast cancers. Breast ultrasound features may reflect pathological and biological characteristics of a breast tumor. This study aimed to explore whether ultrasound features could identify small breast cancers with poor outcomes. ME...

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Autores principales: Shao, Sihui, Yao, Minghua, Li, Chunxiao, Li, Xin, Wang, Jianfeng, Chen, Jing, Zheng, Yi, Wu, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061109/
https://www.ncbi.nlm.nih.gov/pubmed/37007100
http://dx.doi.org/10.3389/fonc.2023.1103397
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author Shao, Sihui
Yao, Minghua
Li, Chunxiao
Li, Xin
Wang, Jianfeng
Chen, Jing
Zheng, Yi
Wu, Rong
author_facet Shao, Sihui
Yao, Minghua
Li, Chunxiao
Li, Xin
Wang, Jianfeng
Chen, Jing
Zheng, Yi
Wu, Rong
author_sort Shao, Sihui
collection PubMed
description BACKGROUND: Some women die despite the favorable prognosis of small breast cancers. Breast ultrasound features may reflect pathological and biological characteristics of a breast tumor. This study aimed to explore whether ultrasound features could identify small breast cancers with poor outcomes. METHODS: This retrospective study examined confirmed breast cancers with a size of <20 mm diagnosed in our hospital between 02/2008 and 08/2019. Clinicopathological and ultrasound features were compared between alive and deceased breast cancer patients. Survival was analyzed using the Kaplan-Meier curves. Multivariable Cox proportional hazards models were used to examine the factors associated with breast cancer-specific survival (BCSS) and disease-free survival (DFS). RESULTS: Among the 790 patients, the median follow-up was 3.5 years. The deceased group showed higher frequencies of spiculated (36.7% vs. 11.2%, P<0.001), anti-parallel orientation (43.3% vs. 15.4%, P<0.001), and spiculated morphology combined with anti-parallel orientation (30.0% vs. 2.4%, P<0.001). Among 27 patients with spiculated morphology and anti-parallel orientation, nine cancer-specific deaths and 11 recurrences occurred, for a 5-year BCSS of 77.8% and DFS of 66.7%, while 21 breast-cancer deaths and 41 recurrences occurred among the remaining patients with higher 5-year BCSS (97.8%, P<0.001) and DFS (95.4%, P<0.001). Spiculated and anti-parallel orientation (HR=7.45, 95%CI: 3.26-17.00; HR=6.42, 95%CI: 3.19-12.93), age ≥55 years (HR=5.94, 95%CI: 2.24-15.72; HR=1.98, 95%CI: 1.11-3.54), and lymph nodes metastasis (HR=3.99, 95%CI: 1.89-8.43; HR=2.99, 95%CI: 1.71-5.23) were independently associated with poor BCSS and DFS. CONCLUSIONS: Spiculated and anti-parallel orientation at ultrasound are associated with poor BCSS and DFS in patients with primary breast cancer <20 mm.
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spelling pubmed-100611092023-03-31 Ultrasound features for prediction of long-term outcomes of women with primary breast cancer <20 mm Shao, Sihui Yao, Minghua Li, Chunxiao Li, Xin Wang, Jianfeng Chen, Jing Zheng, Yi Wu, Rong Front Oncol Oncology BACKGROUND: Some women die despite the favorable prognosis of small breast cancers. Breast ultrasound features may reflect pathological and biological characteristics of a breast tumor. This study aimed to explore whether ultrasound features could identify small breast cancers with poor outcomes. METHODS: This retrospective study examined confirmed breast cancers with a size of <20 mm diagnosed in our hospital between 02/2008 and 08/2019. Clinicopathological and ultrasound features were compared between alive and deceased breast cancer patients. Survival was analyzed using the Kaplan-Meier curves. Multivariable Cox proportional hazards models were used to examine the factors associated with breast cancer-specific survival (BCSS) and disease-free survival (DFS). RESULTS: Among the 790 patients, the median follow-up was 3.5 years. The deceased group showed higher frequencies of spiculated (36.7% vs. 11.2%, P<0.001), anti-parallel orientation (43.3% vs. 15.4%, P<0.001), and spiculated morphology combined with anti-parallel orientation (30.0% vs. 2.4%, P<0.001). Among 27 patients with spiculated morphology and anti-parallel orientation, nine cancer-specific deaths and 11 recurrences occurred, for a 5-year BCSS of 77.8% and DFS of 66.7%, while 21 breast-cancer deaths and 41 recurrences occurred among the remaining patients with higher 5-year BCSS (97.8%, P<0.001) and DFS (95.4%, P<0.001). Spiculated and anti-parallel orientation (HR=7.45, 95%CI: 3.26-17.00; HR=6.42, 95%CI: 3.19-12.93), age ≥55 years (HR=5.94, 95%CI: 2.24-15.72; HR=1.98, 95%CI: 1.11-3.54), and lymph nodes metastasis (HR=3.99, 95%CI: 1.89-8.43; HR=2.99, 95%CI: 1.71-5.23) were independently associated with poor BCSS and DFS. CONCLUSIONS: Spiculated and anti-parallel orientation at ultrasound are associated with poor BCSS and DFS in patients with primary breast cancer <20 mm. Frontiers Media S.A. 2023-03-16 /pmc/articles/PMC10061109/ /pubmed/37007100 http://dx.doi.org/10.3389/fonc.2023.1103397 Text en Copyright © 2023 Shao, Yao, Li, Li, Wang, Chen, Zheng and Wu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Shao, Sihui
Yao, Minghua
Li, Chunxiao
Li, Xin
Wang, Jianfeng
Chen, Jing
Zheng, Yi
Wu, Rong
Ultrasound features for prediction of long-term outcomes of women with primary breast cancer <20 mm
title Ultrasound features for prediction of long-term outcomes of women with primary breast cancer <20 mm
title_full Ultrasound features for prediction of long-term outcomes of women with primary breast cancer <20 mm
title_fullStr Ultrasound features for prediction of long-term outcomes of women with primary breast cancer <20 mm
title_full_unstemmed Ultrasound features for prediction of long-term outcomes of women with primary breast cancer <20 mm
title_short Ultrasound features for prediction of long-term outcomes of women with primary breast cancer <20 mm
title_sort ultrasound features for prediction of long-term outcomes of women with primary breast cancer <20 mm
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061109/
https://www.ncbi.nlm.nih.gov/pubmed/37007100
http://dx.doi.org/10.3389/fonc.2023.1103397
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