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Case report: The stroma-rich variant of Castleman’s disease of hyaline-vascular type with atypical stromal cell proliferation and malignant potential: An exceptional rare case occurred in mediastinal lymph node
The stroma-rich variant of Castleman disease of hyaline-vascular type (SR-HVCD) is characterized by interfollicular proliferation of the fibroblastic, myofibroblastic, and/or histiocytic-derived stromal cells, occurred in a background of Castleman disease of hyaline-vascular type (HVCD). It has been...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061130/ https://www.ncbi.nlm.nih.gov/pubmed/37007164 http://dx.doi.org/10.3389/fonc.2023.1008587 |
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author | Shi, Xiaoxin Liao, Mengying Yin, Xiaomin Chen, Yaoli Huang, Chuqiang Yin, Weihua Li, Jian |
author_facet | Shi, Xiaoxin Liao, Mengying Yin, Xiaomin Chen, Yaoli Huang, Chuqiang Yin, Weihua Li, Jian |
author_sort | Shi, Xiaoxin |
collection | PubMed |
description | The stroma-rich variant of Castleman disease of hyaline-vascular type (SR-HVCD) is characterized by interfollicular proliferation of the fibroblastic, myofibroblastic, and/or histiocytic-derived stromal cells, occurred in a background of Castleman disease of hyaline-vascular type (HVCD). It has been considered as a hyperplastic disorder by far. Herein, we presented a case of a 40-year-old male suffering from an occupation in the right middle mediastinum. Microscopically, the lesion was characterized by atretic lymphoid follicles and overgrowth of the interfollicular spindle-shaped cells. Those spindle cells were histologically bland in some areas, while exhibited notable cellular atypia and focal necrosis in other areas. SMA and CD68 were immunostained with a subset of the spindle cells in both areas, whereas p53 staining was only perceived in areas with markedly cellular atypia. In addition, indolent T-lymphoblastic proliferation (iT-LBP) was present inside the lesion. The patient developed multiple sites metastases 4 months after surgery, and succumbed to the disease at 7 months. Our case demonstrates for the first time that SR-HVCD have a tumorigenesis potential rather than a simple hyperplastic process. Such disorder should be carefully evaluated to avoid underdiagnosis. |
format | Online Article Text |
id | pubmed-10061130 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100611302023-03-31 Case report: The stroma-rich variant of Castleman’s disease of hyaline-vascular type with atypical stromal cell proliferation and malignant potential: An exceptional rare case occurred in mediastinal lymph node Shi, Xiaoxin Liao, Mengying Yin, Xiaomin Chen, Yaoli Huang, Chuqiang Yin, Weihua Li, Jian Front Oncol Oncology The stroma-rich variant of Castleman disease of hyaline-vascular type (SR-HVCD) is characterized by interfollicular proliferation of the fibroblastic, myofibroblastic, and/or histiocytic-derived stromal cells, occurred in a background of Castleman disease of hyaline-vascular type (HVCD). It has been considered as a hyperplastic disorder by far. Herein, we presented a case of a 40-year-old male suffering from an occupation in the right middle mediastinum. Microscopically, the lesion was characterized by atretic lymphoid follicles and overgrowth of the interfollicular spindle-shaped cells. Those spindle cells were histologically bland in some areas, while exhibited notable cellular atypia and focal necrosis in other areas. SMA and CD68 were immunostained with a subset of the spindle cells in both areas, whereas p53 staining was only perceived in areas with markedly cellular atypia. In addition, indolent T-lymphoblastic proliferation (iT-LBP) was present inside the lesion. The patient developed multiple sites metastases 4 months after surgery, and succumbed to the disease at 7 months. Our case demonstrates for the first time that SR-HVCD have a tumorigenesis potential rather than a simple hyperplastic process. Such disorder should be carefully evaluated to avoid underdiagnosis. Frontiers Media S.A. 2023-03-16 /pmc/articles/PMC10061130/ /pubmed/37007164 http://dx.doi.org/10.3389/fonc.2023.1008587 Text en Copyright © 2023 Shi, Liao, Yin, Chen, Huang, Yin and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Shi, Xiaoxin Liao, Mengying Yin, Xiaomin Chen, Yaoli Huang, Chuqiang Yin, Weihua Li, Jian Case report: The stroma-rich variant of Castleman’s disease of hyaline-vascular type with atypical stromal cell proliferation and malignant potential: An exceptional rare case occurred in mediastinal lymph node |
title | Case report: The stroma-rich variant of Castleman’s disease of hyaline-vascular type with atypical stromal cell proliferation and malignant potential: An exceptional rare case occurred in mediastinal lymph node |
title_full | Case report: The stroma-rich variant of Castleman’s disease of hyaline-vascular type with atypical stromal cell proliferation and malignant potential: An exceptional rare case occurred in mediastinal lymph node |
title_fullStr | Case report: The stroma-rich variant of Castleman’s disease of hyaline-vascular type with atypical stromal cell proliferation and malignant potential: An exceptional rare case occurred in mediastinal lymph node |
title_full_unstemmed | Case report: The stroma-rich variant of Castleman’s disease of hyaline-vascular type with atypical stromal cell proliferation and malignant potential: An exceptional rare case occurred in mediastinal lymph node |
title_short | Case report: The stroma-rich variant of Castleman’s disease of hyaline-vascular type with atypical stromal cell proliferation and malignant potential: An exceptional rare case occurred in mediastinal lymph node |
title_sort | case report: the stroma-rich variant of castleman’s disease of hyaline-vascular type with atypical stromal cell proliferation and malignant potential: an exceptional rare case occurred in mediastinal lymph node |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061130/ https://www.ncbi.nlm.nih.gov/pubmed/37007164 http://dx.doi.org/10.3389/fonc.2023.1008587 |
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