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Obesity and cancer: Mouse models used in studies
There is increasing evidence that obesity is associated with the occurrence and development of malignant tumors. When studying the relationship between obesity and malignant tumors, it is very important to choose an appropriate animal model. However, BALB/c nude mice and other animals commonly used...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061215/ https://www.ncbi.nlm.nih.gov/pubmed/37007087 http://dx.doi.org/10.3389/fonc.2023.1125178 |
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author | Zhang, Bo-Tao Xu, Jia-Ying Wang, Wei Zeng, Yang Jiang, Jun |
author_facet | Zhang, Bo-Tao Xu, Jia-Ying Wang, Wei Zeng, Yang Jiang, Jun |
author_sort | Zhang, Bo-Tao |
collection | PubMed |
description | There is increasing evidence that obesity is associated with the occurrence and development of malignant tumors. When studying the relationship between obesity and malignant tumors, it is very important to choose an appropriate animal model. However, BALB/c nude mice and other animals commonly used to study tumor xenograft (human-derived tumor cell lines) transplantation models are difficult to induce obesity, while C57BL/6 mice and other model animals commonly used for obesity research are not suitable for tumor xenograft transplantation. Therefore, it is difficult to replicate both obesity and malignancy in animal models at the same time. This review summarizes several experimental animal models and protocols that can simultaneously induce obesity and tumor xenografts. |
format | Online Article Text |
id | pubmed-10061215 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100612152023-03-31 Obesity and cancer: Mouse models used in studies Zhang, Bo-Tao Xu, Jia-Ying Wang, Wei Zeng, Yang Jiang, Jun Front Oncol Oncology There is increasing evidence that obesity is associated with the occurrence and development of malignant tumors. When studying the relationship between obesity and malignant tumors, it is very important to choose an appropriate animal model. However, BALB/c nude mice and other animals commonly used to study tumor xenograft (human-derived tumor cell lines) transplantation models are difficult to induce obesity, while C57BL/6 mice and other model animals commonly used for obesity research are not suitable for tumor xenograft transplantation. Therefore, it is difficult to replicate both obesity and malignancy in animal models at the same time. This review summarizes several experimental animal models and protocols that can simultaneously induce obesity and tumor xenografts. Frontiers Media S.A. 2023-03-16 /pmc/articles/PMC10061215/ /pubmed/37007087 http://dx.doi.org/10.3389/fonc.2023.1125178 Text en Copyright © 2023 Zhang, Xu, Wang, Zeng and Jiang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Zhang, Bo-Tao Xu, Jia-Ying Wang, Wei Zeng, Yang Jiang, Jun Obesity and cancer: Mouse models used in studies |
title | Obesity and cancer: Mouse models used in studies |
title_full | Obesity and cancer: Mouse models used in studies |
title_fullStr | Obesity and cancer: Mouse models used in studies |
title_full_unstemmed | Obesity and cancer: Mouse models used in studies |
title_short | Obesity and cancer: Mouse models used in studies |
title_sort | obesity and cancer: mouse models used in studies |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061215/ https://www.ncbi.nlm.nih.gov/pubmed/37007087 http://dx.doi.org/10.3389/fonc.2023.1125178 |
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