G4-binding drugs, chlorpromazine and prochlorperazine, repurposed against COVID-19 infection in hamsters

The COVID-19 pandemic caused by SARS-CoV-2 has caused millions of infections and deaths worldwide. Limited treatment options and the threat from emerging variants underline the need for novel and widely accessible therapeutics. G-quadruplexes (G4s) are nucleic acid secondary structures known to affe...

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Detalles Bibliográficos
Autores principales: Roy, Shuvra Shekhar, Sharma, Shalu, Rizvi, Zaigham Abbas, Sinha, Dipanjali, Gupta, Divya, Rophina, Mercy, Sehgal, Paras, Sadhu, Srikanth, Tripathy, Manas Ranjan, Samal, Sweety, Maiti, Souvik, Scaria, Vinod, Sivasubbu, Sridhar, Awasthi, Amit, Harshan, Krishnan H., Jain, Sanjeev, Chowdhury, Shantanu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061221/
https://www.ncbi.nlm.nih.gov/pubmed/37006620
http://dx.doi.org/10.3389/fmolb.2023.1133123

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