Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer

Bicarbonate transport is a pre‐existing mechanism of pH regulation in pancreatic ductal cells. In a recent study, Cappellesso et al. demonstrated that pancreatic ductal adenocarcinoma metabolic rewiring creates an acidic environment, enhanced by bicarbonate import into cancer cells via SLC4A4. This...

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Detalles Bibliográficos
Autores principales: Kay, Emily J., Zanivan, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061281/
https://www.ncbi.nlm.nih.gov/pubmed/36807529
http://dx.doi.org/10.1002/1878-0261.13400
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author Kay, Emily J.
Zanivan, Sara
author_facet Kay, Emily J.
Zanivan, Sara
author_sort Kay, Emily J.
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description Bicarbonate transport is a pre‐existing mechanism of pH regulation in pancreatic ductal cells. In a recent study, Cappellesso et al. demonstrated that pancreatic ductal adenocarcinoma metabolic rewiring creates an acidic environment, enhanced by bicarbonate import into cancer cells via SLC4A4. This acidity favours protumourigenic immunosuppression. Targeting SLC4A4 neutralises environmental pH and restores antitumour immunity, sensitising tumours to immune checkpoint blockade.
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spelling pubmed-100612812023-03-31 Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer Kay, Emily J. Zanivan, Sara Mol Oncol Commentaries Bicarbonate transport is a pre‐existing mechanism of pH regulation in pancreatic ductal cells. In a recent study, Cappellesso et al. demonstrated that pancreatic ductal adenocarcinoma metabolic rewiring creates an acidic environment, enhanced by bicarbonate import into cancer cells via SLC4A4. This acidity favours protumourigenic immunosuppression. Targeting SLC4A4 neutralises environmental pH and restores antitumour immunity, sensitising tumours to immune checkpoint blockade. John Wiley and Sons Inc. 2023-03-04 /pmc/articles/PMC10061281/ /pubmed/36807529 http://dx.doi.org/10.1002/1878-0261.13400 Text en © 2023 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentaries
Kay, Emily J.
Zanivan, Sara
Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer
title Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer
title_full Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer
title_fullStr Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer
title_full_unstemmed Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer
title_short Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer
title_sort bicarbonate transport as regulator of antitumour immunity in pancreatic cancer
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061281/
https://www.ncbi.nlm.nih.gov/pubmed/36807529
http://dx.doi.org/10.1002/1878-0261.13400
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