Replication stress increases mitochondrial metabolism and mitophagy in FANCD2 deficient fetal liver hematopoietic stem cells

Fanconi Anemia (FA) is an inherited bone marrow (BM) failure disorder commonly diagnosed during school age. However, in murine models, disrupted function of FA genes leads to a much earlier decline in fetal liver hematopoietic stem cell (FL HSC) number that is associated with increased replication s...

Descripción completa

Detalles Bibliográficos
Autores principales: Mochizuki-Kashio, Makiko, Otsuki, Noriko, Fujiki, Kota, Abdelhamd, Sherif, Kurre, Peter, Grompe, Markus, Iwama, Atsushi, Saito, Kayoko, Nakamura-Ishizu, Ayako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061350/
https://www.ncbi.nlm.nih.gov/pubmed/37007148
http://dx.doi.org/10.3389/fonc.2023.1108430

Ejemplares similares

Ejemplares similares