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Rediscovery of Tetronomycin as a Broad-Spectrum and Potent Antibiotic against Drug-Resistant Gram-Positive Bacteria

[Image: see text] Tetronomycin (1), first isolated from a cultured broth of Streptomyces sp. by Juslen et al. in 1974, is a polycyclic polyether compound. However, the biological activity of 1 has not been thoroughly examined. In this study, we found that 1 exhibits more potent antibacterial activit...

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Detalles Bibliográficos
Autores principales: Kimishima, Aoi, Tsuruoka, Iori, Kanto, Hiroki, Tsutsumi, Hayama, Arima, Naoaki, Sakai, Kazunari, Sugamata, Miho, Matsui, Hidehito, Watanabe, Yoshihiro, Iwatsuki, Masato, Honsho, Masako, Naher, Kamrun, Inahashi, Yuki, Hanaki, Hideaki, Asami, Yukihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061530/
https://www.ncbi.nlm.nih.gov/pubmed/37008151
http://dx.doi.org/10.1021/acsomega.3c00651
Descripción
Sumario:[Image: see text] Tetronomycin (1), first isolated from a cultured broth of Streptomyces sp. by Juslen et al. in 1974, is a polycyclic polyether compound. However, the biological activity of 1 has not been thoroughly examined. In this study, we found that 1 exhibits more potent antibacterial activity than two well-known antibacterial drugs (vancomycin and linezolid) and is effective against several drug-resistant clinical isolates including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci. Furthermore, we reassigned the (13)C NMR spectra of 1 and performed a preliminary structure–activity relationship study of 1 to synthesize a chemical probe for target identification, which implied different targets based on its ionophore activity.