Probing the Allosteric Modulation of P-Glycoprotein: A Medicinal Chemistry Approach Toward the Identification of Noncompetitive P-Gp Inhibitors

[Image: see text] A medicinal chemistry approach combining in silico and in vitro methodologies was performed aiming at identifying and characterizing putative allosteric drug-binding sites (aDBSs) at the interface of the transmembrane- and nucleotide-binding domains (TMD-NBD) of P-glycoprotein. Two...

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Detalles Bibliográficos
Autores principales: Bonito, Cátia A., Ferreira, Ricardo J., Ferreira, Maria-José. U., Durães, Fernando, Sousa, Emília, Gillet, Jean-Pierre, Cordeiro, M. Natália D. S., dos Santos, Daniel J. V. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061618/
https://www.ncbi.nlm.nih.gov/pubmed/37008154
http://dx.doi.org/10.1021/acsomega.2c08273

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