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Kynurenic acid blunts A1 astrocyte activation against neurodegeneration in HIV-associated neurocognitive disorders

Despite extensive astrocyte activation in patients suffering from HIV-associated neurocognitive disorders (HAND), little is known about the contribution of astrocytes to HAND neuropathology. Here, we report that the robust activation of neurotoxic astrocytes (A1 astrocytes) in the CNS promotes neuro...

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Detalles Bibliográficos
Autores principales:	Lun, Jingxian, Li, Yubin, Gao, Xuefeng, Gong, Zelong, Chen, Xiaoliang, Zou, Jinhu, Zhou, Chengxing, Huang, Yuanyuan, Zhou, Bingliang, Huang, Pengwei, Cao, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061717/ https://www.ncbi.nlm.nih.gov/pubmed/36997969 http://dx.doi.org/10.1186/s12974-023-02771-4

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