Cargando…

The effect of ambient ozone exposure on three types of diabetes: a meta-analysis

BACKGROUND: Ozone as an air pollutant is gradually becoming a threat to people's health. However, the effect of ozone exposure on risk of developing diabetes, a fast-growing global metabolic disease, remains controversial. OBJECTIVE: To evaluate the impact of ambient ozone exposure on the incid...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Sirui, Zhang, Mingzhi, Zhu, Jiamin, Yang, Xu, Bigambo, Francis Manyori, Snijders, Antoine M., Wang, Xu, Hu, Weiyue, Lv, Wei, Xia, Yankai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061724/
https://www.ncbi.nlm.nih.gov/pubmed/36998068
http://dx.doi.org/10.1186/s12940-023-00981-0
_version_ 1785017350947340288
author Yu, Sirui
Zhang, Mingzhi
Zhu, Jiamin
Yang, Xu
Bigambo, Francis Manyori
Snijders, Antoine M.
Wang, Xu
Hu, Weiyue
Lv, Wei
Xia, Yankai
author_facet Yu, Sirui
Zhang, Mingzhi
Zhu, Jiamin
Yang, Xu
Bigambo, Francis Manyori
Snijders, Antoine M.
Wang, Xu
Hu, Weiyue
Lv, Wei
Xia, Yankai
author_sort Yu, Sirui
collection PubMed
description BACKGROUND: Ozone as an air pollutant is gradually becoming a threat to people's health. However, the effect of ozone exposure on risk of developing diabetes, a fast-growing global metabolic disease, remains controversial. OBJECTIVE: To evaluate the impact of ambient ozone exposure on the incidence rate of type 1, type 2 and gestational diabetes mellitus. METHOD: We systematically searched PubMed, Web of Science, and Cochrane Library databases before July 9, 2022, to determine relevant literature. Data were extracted after quality evaluation according to the Newcastle Ottawa Scale (NOS) and the agency for healthcare research and quality (AHRQ) standards, and a meta-analysis was used to evaluate the correlation between ozone exposure and type 1 diabetes mellitus (T1D), type 2 diabetes mellitus (T2D), and gestational diabetes mellitus (GDM). The heterogeneity test, sensitivity analysis, and publication bias were performed using Stata 16.0. RESULTS: Our search identified 667 studies from three databases, 19 of which were included in our analysis after removing duplicate and ineligible studies. Among the remaining studies, three were on T1D, five were on T2D, and eleven were on GDM. The result showed that ozone exposure was positively correlated with T2D [effect size (ES) = 1.06, 95% CI: 1.02, 1.11] and GDM [pooled odds ratio (OR) = 1.01, 95% CI: 1.00, 1.03]. Subgroup analysis demonstrated that ozone exposure in the first trimester of pregnancy might raise the risk of GDM. However, no significant association was observed between ozone exposure and T1D. CONCLUSION: Long-term exposure to ozone may increase the risk of T2D, and daily ozone exposure during pregnancy was a hazard factor for developing GDM. Decreasing ambient ozone pollution may reduce the burden of both diseases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12940-023-00981-0.
format Online
Article
Text
id pubmed-10061724
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-100617242023-03-31 The effect of ambient ozone exposure on three types of diabetes: a meta-analysis Yu, Sirui Zhang, Mingzhi Zhu, Jiamin Yang, Xu Bigambo, Francis Manyori Snijders, Antoine M. Wang, Xu Hu, Weiyue Lv, Wei Xia, Yankai Environ Health Research BACKGROUND: Ozone as an air pollutant is gradually becoming a threat to people's health. However, the effect of ozone exposure on risk of developing diabetes, a fast-growing global metabolic disease, remains controversial. OBJECTIVE: To evaluate the impact of ambient ozone exposure on the incidence rate of type 1, type 2 and gestational diabetes mellitus. METHOD: We systematically searched PubMed, Web of Science, and Cochrane Library databases before July 9, 2022, to determine relevant literature. Data were extracted after quality evaluation according to the Newcastle Ottawa Scale (NOS) and the agency for healthcare research and quality (AHRQ) standards, and a meta-analysis was used to evaluate the correlation between ozone exposure and type 1 diabetes mellitus (T1D), type 2 diabetes mellitus (T2D), and gestational diabetes mellitus (GDM). The heterogeneity test, sensitivity analysis, and publication bias were performed using Stata 16.0. RESULTS: Our search identified 667 studies from three databases, 19 of which were included in our analysis after removing duplicate and ineligible studies. Among the remaining studies, three were on T1D, five were on T2D, and eleven were on GDM. The result showed that ozone exposure was positively correlated with T2D [effect size (ES) = 1.06, 95% CI: 1.02, 1.11] and GDM [pooled odds ratio (OR) = 1.01, 95% CI: 1.00, 1.03]. Subgroup analysis demonstrated that ozone exposure in the first trimester of pregnancy might raise the risk of GDM. However, no significant association was observed between ozone exposure and T1D. CONCLUSION: Long-term exposure to ozone may increase the risk of T2D, and daily ozone exposure during pregnancy was a hazard factor for developing GDM. Decreasing ambient ozone pollution may reduce the burden of both diseases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12940-023-00981-0. BioMed Central 2023-03-30 /pmc/articles/PMC10061724/ /pubmed/36998068 http://dx.doi.org/10.1186/s12940-023-00981-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Yu, Sirui
Zhang, Mingzhi
Zhu, Jiamin
Yang, Xu
Bigambo, Francis Manyori
Snijders, Antoine M.
Wang, Xu
Hu, Weiyue
Lv, Wei
Xia, Yankai
The effect of ambient ozone exposure on three types of diabetes: a meta-analysis
title The effect of ambient ozone exposure on three types of diabetes: a meta-analysis
title_full The effect of ambient ozone exposure on three types of diabetes: a meta-analysis
title_fullStr The effect of ambient ozone exposure on three types of diabetes: a meta-analysis
title_full_unstemmed The effect of ambient ozone exposure on three types of diabetes: a meta-analysis
title_short The effect of ambient ozone exposure on three types of diabetes: a meta-analysis
title_sort effect of ambient ozone exposure on three types of diabetes: a meta-analysis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061724/
https://www.ncbi.nlm.nih.gov/pubmed/36998068
http://dx.doi.org/10.1186/s12940-023-00981-0
work_keys_str_mv AT yusirui theeffectofambientozoneexposureonthreetypesofdiabetesametaanalysis
AT zhangmingzhi theeffectofambientozoneexposureonthreetypesofdiabetesametaanalysis
AT zhujiamin theeffectofambientozoneexposureonthreetypesofdiabetesametaanalysis
AT yangxu theeffectofambientozoneexposureonthreetypesofdiabetesametaanalysis
AT bigambofrancismanyori theeffectofambientozoneexposureonthreetypesofdiabetesametaanalysis
AT snijdersantoinem theeffectofambientozoneexposureonthreetypesofdiabetesametaanalysis
AT wangxu theeffectofambientozoneexposureonthreetypesofdiabetesametaanalysis
AT huweiyue theeffectofambientozoneexposureonthreetypesofdiabetesametaanalysis
AT lvwei theeffectofambientozoneexposureonthreetypesofdiabetesametaanalysis
AT xiayankai theeffectofambientozoneexposureonthreetypesofdiabetesametaanalysis
AT yusirui effectofambientozoneexposureonthreetypesofdiabetesametaanalysis
AT zhangmingzhi effectofambientozoneexposureonthreetypesofdiabetesametaanalysis
AT zhujiamin effectofambientozoneexposureonthreetypesofdiabetesametaanalysis
AT yangxu effectofambientozoneexposureonthreetypesofdiabetesametaanalysis
AT bigambofrancismanyori effectofambientozoneexposureonthreetypesofdiabetesametaanalysis
AT snijdersantoinem effectofambientozoneexposureonthreetypesofdiabetesametaanalysis
AT wangxu effectofambientozoneexposureonthreetypesofdiabetesametaanalysis
AT huweiyue effectofambientozoneexposureonthreetypesofdiabetesametaanalysis
AT lvwei effectofambientozoneexposureonthreetypesofdiabetesametaanalysis
AT xiayankai effectofambientozoneexposureonthreetypesofdiabetesametaanalysis