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Associations of alcohol consumption with breast tissue composition

BACKGROUND: We investigated the associations of alcohol with percentage of epithelium, stroma, fibroglandular tissue (epithelium + stroma), and fat in benign breast biopsy samples. METHODS: We included 857 cancer-free women with biopsy-confirmed benign breast disease within the Nurses’ Health Study...

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Autores principales: Yaghjyan, Lusine, Heng, Yujing J., Baker, Gabrielle M., Rosner, Bernard A., Tamimi, Rulla M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061845/
https://www.ncbi.nlm.nih.gov/pubmed/36998083
http://dx.doi.org/10.1186/s13058-023-01638-z
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author Yaghjyan, Lusine
Heng, Yujing J.
Baker, Gabrielle M.
Rosner, Bernard A.
Tamimi, Rulla M.
author_facet Yaghjyan, Lusine
Heng, Yujing J.
Baker, Gabrielle M.
Rosner, Bernard A.
Tamimi, Rulla M.
author_sort Yaghjyan, Lusine
collection PubMed
description BACKGROUND: We investigated the associations of alcohol with percentage of epithelium, stroma, fibroglandular tissue (epithelium + stroma), and fat in benign breast biopsy samples. METHODS: We included 857 cancer-free women with biopsy-confirmed benign breast disease within the Nurses’ Health Study (NHS) and NHSII cohorts. Percentage of each tissue was measured on whole slide images using a deep-learning algorithm and then log-transformed. Alcohol consumption (recent and cumulative average) was assessed with semi-quantitative food frequency questionnaires. Regression estimates were adjusted for known breast cancer risk factors. All tests were 2-sided. RESULTS: Alcohol was inversely associated with % of stroma and fibroglandular tissue (recent ≥ 22 g/day vs. none: stroma: β = − 0.08, 95% Confidence Interval [CI] − 0.13; − 0.03; fibroglandular: β = − 0.08, 95% CI − 0.13; − 0.04; cumulative ≥ 22 g/day vs. none: stroma: β = − 0.08, 95% CI − 0.13; − 0.02; fibroglandular: β = − 0.09, 95% CI − 0.14; − 0.04) and positively associated with fat % (recent ≥ 22 g/day vs. none: β = 0.30, 95% CI 0.03; 0.57; cumulative ≥ 22 g/day vs. none: β = 0.32, 95% CI 0.04; 0.61). In stratified analysis, alcohol consumption was not associated with tissue measures in premenopausal women. In postmenopausal women, cumulative alcohol use was inversely associated with % of stroma and fibroglandular tissue and positively associated with fat % (≥ 22 g/day vs. none: stroma: β = − 0.16, 95% CI − 0.28; − 0.07; fibroglandular: β = − 0.18, 95% CI − 0.28; − 0.07; fat: β = 0.61, 95% CI 0.01; 1.22), with similar results for recent alcohol use. CONCLUSION: Our findings suggest that alcohol consumption is associated with smaller % of stroma and fibroglandular tissue and a greater % of fat in postmenopausal women. Future studies are warranted to confirm our findings and to elucidate the underlying biological mechanisms. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13058-023-01638-z.
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spelling pubmed-100618452023-03-31 Associations of alcohol consumption with breast tissue composition Yaghjyan, Lusine Heng, Yujing J. Baker, Gabrielle M. Rosner, Bernard A. Tamimi, Rulla M. Breast Cancer Res Research BACKGROUND: We investigated the associations of alcohol with percentage of epithelium, stroma, fibroglandular tissue (epithelium + stroma), and fat in benign breast biopsy samples. METHODS: We included 857 cancer-free women with biopsy-confirmed benign breast disease within the Nurses’ Health Study (NHS) and NHSII cohorts. Percentage of each tissue was measured on whole slide images using a deep-learning algorithm and then log-transformed. Alcohol consumption (recent and cumulative average) was assessed with semi-quantitative food frequency questionnaires. Regression estimates were adjusted for known breast cancer risk factors. All tests were 2-sided. RESULTS: Alcohol was inversely associated with % of stroma and fibroglandular tissue (recent ≥ 22 g/day vs. none: stroma: β = − 0.08, 95% Confidence Interval [CI] − 0.13; − 0.03; fibroglandular: β = − 0.08, 95% CI − 0.13; − 0.04; cumulative ≥ 22 g/day vs. none: stroma: β = − 0.08, 95% CI − 0.13; − 0.02; fibroglandular: β = − 0.09, 95% CI − 0.14; − 0.04) and positively associated with fat % (recent ≥ 22 g/day vs. none: β = 0.30, 95% CI 0.03; 0.57; cumulative ≥ 22 g/day vs. none: β = 0.32, 95% CI 0.04; 0.61). In stratified analysis, alcohol consumption was not associated with tissue measures in premenopausal women. In postmenopausal women, cumulative alcohol use was inversely associated with % of stroma and fibroglandular tissue and positively associated with fat % (≥ 22 g/day vs. none: stroma: β = − 0.16, 95% CI − 0.28; − 0.07; fibroglandular: β = − 0.18, 95% CI − 0.28; − 0.07; fat: β = 0.61, 95% CI 0.01; 1.22), with similar results for recent alcohol use. CONCLUSION: Our findings suggest that alcohol consumption is associated with smaller % of stroma and fibroglandular tissue and a greater % of fat in postmenopausal women. Future studies are warranted to confirm our findings and to elucidate the underlying biological mechanisms. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13058-023-01638-z. BioMed Central 2023-03-30 2023 /pmc/articles/PMC10061845/ /pubmed/36998083 http://dx.doi.org/10.1186/s13058-023-01638-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Yaghjyan, Lusine
Heng, Yujing J.
Baker, Gabrielle M.
Rosner, Bernard A.
Tamimi, Rulla M.
Associations of alcohol consumption with breast tissue composition
title Associations of alcohol consumption with breast tissue composition
title_full Associations of alcohol consumption with breast tissue composition
title_fullStr Associations of alcohol consumption with breast tissue composition
title_full_unstemmed Associations of alcohol consumption with breast tissue composition
title_short Associations of alcohol consumption with breast tissue composition
title_sort associations of alcohol consumption with breast tissue composition
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061845/
https://www.ncbi.nlm.nih.gov/pubmed/36998083
http://dx.doi.org/10.1186/s13058-023-01638-z
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