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Intraoperative hemodialysis during open-heart surgery in patients with severe chronic kidney disease: a retrospective cohort study

BACKGROUND: Acute kidney injury and chronic kidney disease (CKD) after cardiac surgery are associated with poor renal prognosis and increased mortality. The impact of intraoperative hemodialysis (IHD) on postoperative renal function remains unknown. We aimed to evaluate the utility of IHD during ope...

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Autores principales: Inoue, Takahiro, Kuji, Hiroshi, Nagaoka, Kanako, Akanuma, Takafumi, Fukuda, Junko, Matsui, Hiroki, Tanabe, Hiroaki, Ohara, Mamiko, Suzuki, Tomo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061876/
https://www.ncbi.nlm.nih.gov/pubmed/36991338
http://dx.doi.org/10.1186/s12882-023-03142-0
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author Inoue, Takahiro
Kuji, Hiroshi
Nagaoka, Kanako
Akanuma, Takafumi
Fukuda, Junko
Matsui, Hiroki
Tanabe, Hiroaki
Ohara, Mamiko
Suzuki, Tomo
author_facet Inoue, Takahiro
Kuji, Hiroshi
Nagaoka, Kanako
Akanuma, Takafumi
Fukuda, Junko
Matsui, Hiroki
Tanabe, Hiroaki
Ohara, Mamiko
Suzuki, Tomo
author_sort Inoue, Takahiro
collection PubMed
description BACKGROUND: Acute kidney injury and chronic kidney disease (CKD) after cardiac surgery are associated with poor renal prognosis and increased mortality. The impact of intraoperative hemodialysis (IHD) on postoperative renal function remains unknown. We aimed to evaluate the utility of IHD during open-heart surgery in patients with severe non-dialysis-dependent chronic kidney disease (CKD-NDD) and its association with clinical outcomes. METHODS: This was a single-center retrospective cohort study that employed IHD during non-emergency open-heart surgery in patients with CKD stage G4 or G5. Patients who underwent emergent surgery, chronic dialysis, and/or kidney transplantation were excluded. We retrospectively compared the clinical characteristics and outcomes between patients from the IHD and non-IHD groups. The primary outcomes were 90-day mortality and postoperative initiation of renal replacement therapy (RRT). RESULTS: Twenty-eight patients were categorized into the IHD group and 33 into the non-IHD group. When comparing the IHD and non-IHD groups, men accounted for 60.7 vs. 50.3% of patients, the mean patient age was 74.5 (standard deviation [SD] 7.0) vs. 72.9 (SD 9.4) years (p = 0.744), and the proportion of patients with CKD G4 was 67.9 vs. 84.9% (p = 0.138). Regarding clinical outcomes, no significant differences were observed in the 90-day mortality (7.1 vs. 3.0%; p = 0.482) and 30-day RRT (17.9 vs. 30.3%; p = 0.373) rates between the groups. Among the patients with CKD G4, the IHD group had significantly lower 30-day RRT rates than the non-IHD group (0 vs. 25.0%; p = 0.032). RRT initiation was less likely for patients with CKD G4 (odds ratio 0.07, 95% confidence interval [CI] 0.01–0.37; p = 0.002); however, IHD did not significantly decrease the incidence of poor clinical outcomes (odds ratio 0.20, 95% CI 0.04–1.07; p = 0.061). CONCLUSIONS: IHD during open-heart surgery in patients with CKD-NDD did not improve their clinical outcomes with regards to postoperative dialysis. However, for patients with CKD G4, IHD may be useful for postoperative cardiac management.
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spelling pubmed-100618762023-03-31 Intraoperative hemodialysis during open-heart surgery in patients with severe chronic kidney disease: a retrospective cohort study Inoue, Takahiro Kuji, Hiroshi Nagaoka, Kanako Akanuma, Takafumi Fukuda, Junko Matsui, Hiroki Tanabe, Hiroaki Ohara, Mamiko Suzuki, Tomo BMC Nephrol Research Article BACKGROUND: Acute kidney injury and chronic kidney disease (CKD) after cardiac surgery are associated with poor renal prognosis and increased mortality. The impact of intraoperative hemodialysis (IHD) on postoperative renal function remains unknown. We aimed to evaluate the utility of IHD during open-heart surgery in patients with severe non-dialysis-dependent chronic kidney disease (CKD-NDD) and its association with clinical outcomes. METHODS: This was a single-center retrospective cohort study that employed IHD during non-emergency open-heart surgery in patients with CKD stage G4 or G5. Patients who underwent emergent surgery, chronic dialysis, and/or kidney transplantation were excluded. We retrospectively compared the clinical characteristics and outcomes between patients from the IHD and non-IHD groups. The primary outcomes were 90-day mortality and postoperative initiation of renal replacement therapy (RRT). RESULTS: Twenty-eight patients were categorized into the IHD group and 33 into the non-IHD group. When comparing the IHD and non-IHD groups, men accounted for 60.7 vs. 50.3% of patients, the mean patient age was 74.5 (standard deviation [SD] 7.0) vs. 72.9 (SD 9.4) years (p = 0.744), and the proportion of patients with CKD G4 was 67.9 vs. 84.9% (p = 0.138). Regarding clinical outcomes, no significant differences were observed in the 90-day mortality (7.1 vs. 3.0%; p = 0.482) and 30-day RRT (17.9 vs. 30.3%; p = 0.373) rates between the groups. Among the patients with CKD G4, the IHD group had significantly lower 30-day RRT rates than the non-IHD group (0 vs. 25.0%; p = 0.032). RRT initiation was less likely for patients with CKD G4 (odds ratio 0.07, 95% confidence interval [CI] 0.01–0.37; p = 0.002); however, IHD did not significantly decrease the incidence of poor clinical outcomes (odds ratio 0.20, 95% CI 0.04–1.07; p = 0.061). CONCLUSIONS: IHD during open-heart surgery in patients with CKD-NDD did not improve their clinical outcomes with regards to postoperative dialysis. However, for patients with CKD G4, IHD may be useful for postoperative cardiac management. BioMed Central 2023-03-30 /pmc/articles/PMC10061876/ /pubmed/36991338 http://dx.doi.org/10.1186/s12882-023-03142-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Inoue, Takahiro
Kuji, Hiroshi
Nagaoka, Kanako
Akanuma, Takafumi
Fukuda, Junko
Matsui, Hiroki
Tanabe, Hiroaki
Ohara, Mamiko
Suzuki, Tomo
Intraoperative hemodialysis during open-heart surgery in patients with severe chronic kidney disease: a retrospective cohort study
title Intraoperative hemodialysis during open-heart surgery in patients with severe chronic kidney disease: a retrospective cohort study
title_full Intraoperative hemodialysis during open-heart surgery in patients with severe chronic kidney disease: a retrospective cohort study
title_fullStr Intraoperative hemodialysis during open-heart surgery in patients with severe chronic kidney disease: a retrospective cohort study
title_full_unstemmed Intraoperative hemodialysis during open-heart surgery in patients with severe chronic kidney disease: a retrospective cohort study
title_short Intraoperative hemodialysis during open-heart surgery in patients with severe chronic kidney disease: a retrospective cohort study
title_sort intraoperative hemodialysis during open-heart surgery in patients with severe chronic kidney disease: a retrospective cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061876/
https://www.ncbi.nlm.nih.gov/pubmed/36991338
http://dx.doi.org/10.1186/s12882-023-03142-0
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