Cargando…

RRM2 and CDC6 are novel effectors of XBP1-mediated endocrine resistance and predictive markers of tamoxifen sensitivity

BACKGROUND: Endocrine-resistant breast cancers have elevated expression of XBP1, where it drives endocrine resistance by controlling the expression of its target genes. Despite the in-depth understanding of the biological functions of XBP1 in ER-positive breast cancer, effectors of endocrine resista...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barua, David, Sultana, Afrin, Islam, Md Nahidul, Cox, Fergus, Gupta, Ananya, Gupta, Sanjeev
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061897/ https://www.ncbi.nlm.nih.gov/pubmed/36997866 http://dx.doi.org/10.1186/s12885-023-10745-1

Ejemplares similares

XBP1 increases transactivation of somatic mutants of ESR1 and loss of XBP1 reverses endocrine resistance conferred by gain-of-function Y537S ESR1 mutation
por: Barua, David, et al.
Publicado: (2020)

Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death
por: Hossain, Muhammad Mosaraf, et al.
Publicado: (2018)

UPR-Induced miR-616 Inhibits Human Breast Cancer Cell Growth and Migration by Targeting c-MYC
por: Arabkari, Vahid, et al.
Publicado: (2023)

Pathway-Centric Integrative Analysis Identifies RRM2 as a Prognostic Marker in Breast Cancer Associated with Poor Survival and Tamoxifen Resistance()()()
por: Putluri, Nagireddy, et al.
Publicado: (2014)

Repression of viral gene expression and replication by the unfolded protein response effector XBP1u
por: Hinte, Florian, et al.
Publicado: (2020)

Cdc37 suppression induces plasma cell immaturation and bortezomib resistance in multiple myeloma via Xbp1s
por: Zang, Meirong, et al.
Publicado: (2020)

RRM1 *151A>T, RRM1 ‐756T>C, and RRM1 ‐585T>Gis associated with increased susceptibility of lung cancer in Chinese patients
por: Xu, Xiao‐Ling, et al.
Publicado: (2016)

PCAF interacts with XBP-1S and mediates XBP-1S-dependent transcription
por: Lew, Qiao Jing, et al.
Publicado: (2011)

The Borg family of Cdc42 effector proteins Cdc42EP1–5
por: Farrugia, Aaron J., et al.
Publicado: (2016)

MCM3 upregulation confers endocrine resistance in breast cancer and is a predictive marker of diminished tamoxifen benefit
por: Løkkegaard, Sanne, et al.
Publicado: (2021)

A novel chemical, STF-083010, reverses tamoxifen-related drug resistance in breast cancer by inhibiting IRE1/XBP1
por: Ming, Jie, et al.
Publicado: (2015)

NIEHS and CDC track human exposure to endocrine disruptors.
por: Manuel, J
Publicado: (1999)

The evolutionary history of effectors downstream of Cdc42 and Rac
por: Cotteret, Sophie, et al.
Publicado: (2002)

Cdc42 Effector Protein 3 Interacts With Cdc42 in Regulating Xenopus Somite Segmentation
por: Kho, Mary, et al.
Publicado: (2019)

The RRM-mediated RNA binding activity in T. brucei RAP1 is essential for VSG monoallelic expression
por: Gaurav, Amit Kumar, et al.
Publicado: (2023)

The IL-15-AKT-XBP1s signaling pathway contributes to effector functions and survival in human NK cells
por: Wang, Yufeng, et al.
Publicado: (2018)

Identification of CKS2 and RRM2 as potential markers of vitiligo using bioinformatics analysis
por: Miao, Yu, et al.
Publicado: (2022)

Endocrine and clinical consequences of combination tamoxifen-aminoglutethimide in postmenopausal breast cancer.
por: Dowsett, M., et al.
Publicado: (1984)

XBP-1 image overhaul
por: Van Epps, Heather L.
Publicado: (2005)

Erratum to, “Pathway-Centric Integrative Analysis Identifies RRM2 as a Prognostic Marker in Breast Cancer Associated with Poor Survival Tamoxifen Resistance” published in Neoplasia Volume, 16 number 5 on pages 390-402
Publicado: (2014)

miRNAs regulated by estrogens, tamoxifen, and endocrine disruptors and their downstream gene targets
por: Klinge, Carolyn M.
Publicado: (2015)

Cost-effectiveness of Tamoxifen, Aromatase Inhibitor, and Switch Therapy (Adjuvant Endocrine Therapy) for Breast Cancer in Hormone Receptor Positive Postmenopausal Women in India
por: Butani, Dimple, et al.
Publicado: (2021)

Gene aberrations of RRM1 and RRM2B and outcome of advanced breast cancer after treatment with docetaxel with or without gemcitabine
por: Jørgensen, Charlotte LT, et al.
Publicado: (2013)

Structural study of the Fox-1 RRM protein hydration reveals a role for key water molecules in RRM-RNA recognition
por: Krepl, Miroslav, et al.
Publicado: (2017)

The down-regulation of XBP1, an unfolded protein response effector, promotes acute kidney injury to chronic kidney disease transition
por: Chen, Jia-Huang, et al.
Publicado: (2022)

Distinct Roles of Cdc42 in Thymopoiesis and Effector and Memory T Cell Differentiation
por: Guo, Fukun, et al.
Publicado: (2011)

Improving effector functions of antibodies for cancer treatment: Enhancing ADCC and CDC
por: Natsume, Akito, et al.
Publicado: (2009)

The CDC42 effector protein MRCKβ autophosphorylates on Threonine 1108
por: Unbekandt, Mathieu, et al.
Publicado: (2019)

Online measurement of temperature and relative humidity as marker tools for quality changes in onion bulbs during storage
por: Islam, Md. Nahidul, et al.
Publicado: (2019)

HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1α-XBP1 Signaling through a Physical Interaction
por: Gupta, Sanjeev, et al.
Publicado: (2010)

The Clinical and Prognostic Significance of Ribonucleotide Reductase Subunits RRM1 and RRM2 mRNA Levels in Patients with Chronic Lymphocytic Leukemia
por: Chatzidavid, Sevastianos, et al.
Publicado: (2023)

The Role of XBP1 in bone metabolism
por: Lv, Wenhao, et al.
Publicado: (2023)

pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response
por: Yoshida, Hiderou, et al.
Publicado: (2006)

Adipocyte Xbp1s overexpression drives uridine production and reduces obesity
por: Deng, Yingfeng, et al.
Publicado: (2018)

Multimodal Hybrid Deep Learning Approach to Detect Tomato Leaf Disease Using Attention Based Dilated Convolution Feature Extractor with Logistic Regression Classification
por: Islam, Md Shofiqul, et al.
Publicado: (2022)

Expression of UPR effector proteins ATF6 and XBP1 reduce colorectal cancer cell proliferation and stemness by activating PERK signaling
por: Spaan, Claudia N., et al.
Publicado: (2019)

Independent prognostic implications of RRM2 in lung adenocarcinoma
por: Ma, Chao, et al.
Publicado: (2020)

Zinc Binds to RRM2 Peptide of TDP-43
por: Golovin, Andrey V., et al.
Publicado: (2020)

KIF20A is a Prognostic Marker for Female Patients with Estrogen Receptor-Positive Breast Cancer and Receiving Tamoxifen as Adjuvant Endocrine Therapy
por: Huang, Xuchen, et al.
Publicado: (2023)

Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis
por: Zhang, Keqiang, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_24621l7fr4b8h0bgapdpsmaj4q