HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer

HOX transcript antisense intergenic RNA (HOTAIR) is an oncogenic non-coding RNA whose expression is strongly correlated with the tumor grade and prognosis of a variety of carcinomas including breast cancer (BC). HOTAIR regulates various target genes via sponging and epigenetic mechanisms and control...

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Autores principales: Raju, Ganji Seeta Rama, Pavitra, Eluri, Bandaru, Sai Samyuktha, Varaprasad, Ganji Lakshmi, Nagaraju, Ganji Purnachandra, Malla, Rama Rao, Huh, Yun Suk, Han, Young-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061914/
https://www.ncbi.nlm.nih.gov/pubmed/36997931
http://dx.doi.org/10.1186/s12943-023-01765-3
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author Raju, Ganji Seeta Rama
Pavitra, Eluri
Bandaru, Sai Samyuktha
Varaprasad, Ganji Lakshmi
Nagaraju, Ganji Purnachandra
Malla, Rama Rao
Huh, Yun Suk
Han, Young-Kyu
author_facet Raju, Ganji Seeta Rama
Pavitra, Eluri
Bandaru, Sai Samyuktha
Varaprasad, Ganji Lakshmi
Nagaraju, Ganji Purnachandra
Malla, Rama Rao
Huh, Yun Suk
Han, Young-Kyu
author_sort Raju, Ganji Seeta Rama
collection PubMed
description HOX transcript antisense intergenic RNA (HOTAIR) is an oncogenic non-coding RNA whose expression is strongly correlated with the tumor grade and prognosis of a variety of carcinomas including breast cancer (BC). HOTAIR regulates various target genes via sponging and epigenetic mechanisms and controls various oncogenic cellular and signaling mechanisms including metastasis and drug resistance. In BC cells, HOTAIR expression is regulated by a variety of transcriptional and epigenetic mechanisms. In this review, we describe the regulatory mechanisms that govern HOTAIR expression during cancer development and explore how HOTAIR drives BC development, metastasis, and drug resistance. In the final section of this review, we focus on the role of HOTAIR in BC management, therapeutic treatment, and prognosis, highlighting its potential therapeutic applications.
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spelling pubmed-100619142023-03-31 HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer Raju, Ganji Seeta Rama Pavitra, Eluri Bandaru, Sai Samyuktha Varaprasad, Ganji Lakshmi Nagaraju, Ganji Purnachandra Malla, Rama Rao Huh, Yun Suk Han, Young-Kyu Mol Cancer Review HOX transcript antisense intergenic RNA (HOTAIR) is an oncogenic non-coding RNA whose expression is strongly correlated with the tumor grade and prognosis of a variety of carcinomas including breast cancer (BC). HOTAIR regulates various target genes via sponging and epigenetic mechanisms and controls various oncogenic cellular and signaling mechanisms including metastasis and drug resistance. In BC cells, HOTAIR expression is regulated by a variety of transcriptional and epigenetic mechanisms. In this review, we describe the regulatory mechanisms that govern HOTAIR expression during cancer development and explore how HOTAIR drives BC development, metastasis, and drug resistance. In the final section of this review, we focus on the role of HOTAIR in BC management, therapeutic treatment, and prognosis, highlighting its potential therapeutic applications. BioMed Central 2023-03-30 /pmc/articles/PMC10061914/ /pubmed/36997931 http://dx.doi.org/10.1186/s12943-023-01765-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Raju, Ganji Seeta Rama
Pavitra, Eluri
Bandaru, Sai Samyuktha
Varaprasad, Ganji Lakshmi
Nagaraju, Ganji Purnachandra
Malla, Rama Rao
Huh, Yun Suk
Han, Young-Kyu
HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer
title HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer
title_full HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer
title_fullStr HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer
title_full_unstemmed HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer
title_short HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer
title_sort hotair: a potential metastatic, drug-resistant and prognostic regulator of breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061914/
https://www.ncbi.nlm.nih.gov/pubmed/36997931
http://dx.doi.org/10.1186/s12943-023-01765-3
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