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Study on the relationship between obesity and complications of Pediatric Epilepsy surgery

OBJECTIVE: Studies have shown that obesity has a significant impact on poor surgical outcomes. However, the relationship between obesity and pediatric epilepsy surgery has not been reported. This study aimed to explore the relationship between obesity and complications of pediatric epilepsy surgery...

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Autores principales: Shen, Lei, Wang, Mengyang, Zhao, Jingwei, Ruan, Yuanyuan, Yang, Jingyi, Chai, Songshan, Dai, Xuan, Yang, Bangkun, Cai, Yuankun, Zhou, Yixuan, Mei, Zhimin, Zheng, Zhixin, Xu, Dongyuan, Guo, Hantao, Lei, Yu, Cheng, Runqi, Yue, Chuqiao, Wang, Tiansheng, Zhao, Yunchang, Liu, Xinyu, Chai, Yibo, Chen, Jingcao, Du, Hao, Xiong, Nanxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061988/
https://www.ncbi.nlm.nih.gov/pubmed/36997989
http://dx.doi.org/10.1186/s12887-023-03948-9
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author Shen, Lei
Wang, Mengyang
Zhao, Jingwei
Ruan, Yuanyuan
Yang, Jingyi
Chai, Songshan
Dai, Xuan
Yang, Bangkun
Cai, Yuankun
Zhou, Yixuan
Mei, Zhimin
Zheng, Zhixin
Xu, Dongyuan
Guo, Hantao
Lei, Yu
Cheng, Runqi
Yue, Chuqiao
Wang, Tiansheng
Zhao, Yunchang
Liu, Xinyu
Chai, Yibo
Chen, Jingcao
Du, Hao
Xiong, Nanxiang
author_facet Shen, Lei
Wang, Mengyang
Zhao, Jingwei
Ruan, Yuanyuan
Yang, Jingyi
Chai, Songshan
Dai, Xuan
Yang, Bangkun
Cai, Yuankun
Zhou, Yixuan
Mei, Zhimin
Zheng, Zhixin
Xu, Dongyuan
Guo, Hantao
Lei, Yu
Cheng, Runqi
Yue, Chuqiao
Wang, Tiansheng
Zhao, Yunchang
Liu, Xinyu
Chai, Yibo
Chen, Jingcao
Du, Hao
Xiong, Nanxiang
author_sort Shen, Lei
collection PubMed
description OBJECTIVE: Studies have shown that obesity has a significant impact on poor surgical outcomes. However, the relationship between obesity and pediatric epilepsy surgery has not been reported. This study aimed to explore the relationship between obesity and complications of pediatric epilepsy surgery and the effect of obesity on the outcome of pediatric epilepsy surgery, and to provide a reference for weight management of children with epilepsy. METHODS: A single-center retrospective analysis of complications in children undergoing epilepsy surgery was conducted. Body mass index (BMI) percentiles were adjusted by age and used as a criterion for assessing obesity in children. According to the adjusted BMI value, the children were divided into the obese group (n = 16) and nonobese group (n = 20). The intraoperative blood loss, operation time, and postoperative fever were compared between the two groups. RESULTS: A total of 36 children were included in the study, including 20 girls and 16 boys. The mean age of the children was 8.0 years old, ranging from 0.8 to 16.9 years old. The mean BMI was 18.1 (kg/m2), ranging from 12.4 (kg/m2) to 28.3 (kg/m2). Sixteen of them were overweight or obese (44.4%). Obesity was associated with higher intraoperative blood loss in children with epilepsy (p = 0.04), and there was no correlation between obesity and operation time (p = 0.21). Obese children had a greater risk of postoperative fever (56.3%) than nonobese children (55.0%), but this was statistically nonsignificant (p = 0.61). The long-term follow-up outcomes showed that 23 patients (63.9%) were seizure-free (Engel grade I), 6 patients (16.7%) had Engel grade II, and 7 patients (19.4%) had Engel grade III. There was no difference in long-term seizure control outcomes between obese and nonobese groups (p = 0.682). There were no permanent neurological complications after surgery. CONCLUSION: Compared with nonobese children with epilepsy, obese children with epilepsy had a higher intraoperative blood loss. It is necessary to conduct early weight management of children with epilepsy as long as possible.
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spelling pubmed-100619882023-03-31 Study on the relationship between obesity and complications of Pediatric Epilepsy surgery Shen, Lei Wang, Mengyang Zhao, Jingwei Ruan, Yuanyuan Yang, Jingyi Chai, Songshan Dai, Xuan Yang, Bangkun Cai, Yuankun Zhou, Yixuan Mei, Zhimin Zheng, Zhixin Xu, Dongyuan Guo, Hantao Lei, Yu Cheng, Runqi Yue, Chuqiao Wang, Tiansheng Zhao, Yunchang Liu, Xinyu Chai, Yibo Chen, Jingcao Du, Hao Xiong, Nanxiang BMC Pediatr Research OBJECTIVE: Studies have shown that obesity has a significant impact on poor surgical outcomes. However, the relationship between obesity and pediatric epilepsy surgery has not been reported. This study aimed to explore the relationship between obesity and complications of pediatric epilepsy surgery and the effect of obesity on the outcome of pediatric epilepsy surgery, and to provide a reference for weight management of children with epilepsy. METHODS: A single-center retrospective analysis of complications in children undergoing epilepsy surgery was conducted. Body mass index (BMI) percentiles were adjusted by age and used as a criterion for assessing obesity in children. According to the adjusted BMI value, the children were divided into the obese group (n = 16) and nonobese group (n = 20). The intraoperative blood loss, operation time, and postoperative fever were compared between the two groups. RESULTS: A total of 36 children were included in the study, including 20 girls and 16 boys. The mean age of the children was 8.0 years old, ranging from 0.8 to 16.9 years old. The mean BMI was 18.1 (kg/m2), ranging from 12.4 (kg/m2) to 28.3 (kg/m2). Sixteen of them were overweight or obese (44.4%). Obesity was associated with higher intraoperative blood loss in children with epilepsy (p = 0.04), and there was no correlation between obesity and operation time (p = 0.21). Obese children had a greater risk of postoperative fever (56.3%) than nonobese children (55.0%), but this was statistically nonsignificant (p = 0.61). The long-term follow-up outcomes showed that 23 patients (63.9%) were seizure-free (Engel grade I), 6 patients (16.7%) had Engel grade II, and 7 patients (19.4%) had Engel grade III. There was no difference in long-term seizure control outcomes between obese and nonobese groups (p = 0.682). There were no permanent neurological complications after surgery. CONCLUSION: Compared with nonobese children with epilepsy, obese children with epilepsy had a higher intraoperative blood loss. It is necessary to conduct early weight management of children with epilepsy as long as possible. BioMed Central 2023-03-30 /pmc/articles/PMC10061988/ /pubmed/36997989 http://dx.doi.org/10.1186/s12887-023-03948-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Shen, Lei
Wang, Mengyang
Zhao, Jingwei
Ruan, Yuanyuan
Yang, Jingyi
Chai, Songshan
Dai, Xuan
Yang, Bangkun
Cai, Yuankun
Zhou, Yixuan
Mei, Zhimin
Zheng, Zhixin
Xu, Dongyuan
Guo, Hantao
Lei, Yu
Cheng, Runqi
Yue, Chuqiao
Wang, Tiansheng
Zhao, Yunchang
Liu, Xinyu
Chai, Yibo
Chen, Jingcao
Du, Hao
Xiong, Nanxiang
Study on the relationship between obesity and complications of Pediatric Epilepsy surgery
title Study on the relationship between obesity and complications of Pediatric Epilepsy surgery
title_full Study on the relationship between obesity and complications of Pediatric Epilepsy surgery
title_fullStr Study on the relationship between obesity and complications of Pediatric Epilepsy surgery
title_full_unstemmed Study on the relationship between obesity and complications of Pediatric Epilepsy surgery
title_short Study on the relationship between obesity and complications of Pediatric Epilepsy surgery
title_sort study on the relationship between obesity and complications of pediatric epilepsy surgery
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061988/
https://www.ncbi.nlm.nih.gov/pubmed/36997989
http://dx.doi.org/10.1186/s12887-023-03948-9
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