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All Domains of SARS-CoV-2 nsp1 Determine Translational Shutoff and Cytotoxicity of the Protein

Replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strongly affects cellular metabolism and results in rapid development of the cytopathic effect (CPE). The hallmarks of virus-induced modifications are inhibition of translation of cellular mRNAs and redirection of the ce...

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Detalles Bibliográficos
Autores principales:	Frolov, Ilya, Agback, Tatiana, Palchevska, Oksana, Dominguez, Francisco, Lomzov, Alexander, Agback, Peter, Frolova, Elena I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Virus-Cell Interactions
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062135/ https://www.ncbi.nlm.nih.gov/pubmed/36847528 http://dx.doi.org/10.1128/jvi.01865-22

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