Cargando…

9-Butyl-Harmol Exerts Antiviral Activity against Newcastle Disease Virus through Targeting GSK-3β and HSP90β

The paramyxoviruses represent a large family of human and animal pathogens that cause significant health and economic burdens worldwide. However, there are no available drugs against the virus. β-carboline alkaloids are a family of naturally occurring and synthetic products with outstanding antivira...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Chongyang, Wang, Ting, Hu, Ruochen, Duan, Liuyuan, Hou, Qili, Han, Yu, Dai, Jiangkun, Wang, Wenbin, Ren, Shanhui, Liu, Haijin, Wang, Xinglong, Xiao, Sa, Li, Na, Wang, Junru, Yang, Zengqi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Vaccines and Antiviral Agents
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062145/ https://www.ncbi.nlm.nih.gov/pubmed/36877059 http://dx.doi.org/10.1128/jvi.01984-22

Ejemplares similares

1-Formyl-β-carboline Derivatives Block Newcastle Disease Virus Proliferation through Suppressing Viral Adsorption and Entry Processes
por: Wang, Chongyang, et al.
Publicado: (2021)

Small-Molecule Antiviral β-d-N(4)-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance
por: Agostini, Maria L., et al.
Publicado: (2019)

Analysis of B Cell Receptor Repertoires Reveals Key Signatures of the Systemic B Cell Response after SARS-CoV-2 Infection
por: Zhang, Yudi, et al.
Publicado: (2022)

Screening of FDA-Approved Drugs for Inhibitors of Japanese Encephalitis Virus Infection
por: Wang, Shaobo, et al.
Publicado: (2017)

Screening and Identification of Lassa Virus Entry Inhibitors from an FDA-Approved Drug Library
por: Wang, Peilin, et al.
Publicado: (2018)

High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses
por: Shen, Liang, et al.
Publicado: (2019)

Antiviral Properties of HIV-1 Capsid Inhibitor GSK878
por: Wang, Chunfu, et al.
Publicado: (2023)

Screening of Botanical Drugs against Lassa Virus Entry
por: Liu, Yang, et al.
Publicado: (2021)

A Heat-Induced Mutation on VP1 of Foot-and-Mouth Disease Virus Serotype O Enhanced Capsid Stability and Immunogenicity
por: Dong, Hu, et al.
Publicado: (2021)

Stable Cell Clones Harboring Self-Replicating SARS-CoV-2 RNAs for Drug Screen
por: Liu, Shufeng, et al.
Publicado: (2022)

Potent Neutralization of SARS-CoV-2 by Hetero-Bivalent Alpaca Nanobodies Targeting the Spike Receptor-Binding Domain
por: Ma, Huan, et al.
Publicado: (2021)

Development and Evaluation of an Ebola Virus Glycoprotein Mucin-Like Domain Replacement System as a New Dendritic Cell-Targeting Vaccine Approach against HIV-1
por: Ao, Zhujun, et al.
Publicado: (2021)

Inactivated SARS-CoV-2 Vaccine Shows Cross-Protection against Bat SARS-Related Coronaviruses in Human ACE2 Transgenic Mice
por: Liu, Mei-Qin, et al.
Publicado: (2022)

In Vitro Identification and In Vivo Confirmation of Inhibitors for Sweet Potato Chlorotic Stunt Virus RNA Silencing Suppressor, a Viral RNase III
por: Wang, Linping, et al.
Publicado: (2021)

A Single Vaccine Protects against SARS-CoV-2 and Influenza Virus in Mice
por: Cao, Kangli, et al.
Publicado: (2022)

Conformational Stability of the Hemagglutinin of H5N1 Influenza A Viruses Influences Susceptibility to Broadly Neutralizing Stem Antibodies
por: Wang, Wei, et al.
Publicado: (2018)

The Pyrimidine Analog FNC Potently Inhibits the Replication of Multiple Enteroviruses
por: Xu, Na, et al.
Publicado: (2020)

Mechanism through Which Retrocyclin Targets Flavivirus Multiplication
por: Jia, Xiaoying, et al.
Publicado: (2021)

Engineering a Live Attenuated Porcine Epidemic Diarrhea Virus Vaccine Candidate via Inactivation of the Viral 2'-O-Methyltransferase and the Endocytosis Signal of the Spike Protein
por: Hou, Yixuan, et al.
Publicado: (2019)

Key Substitutions in the Spike Protein of SARS-CoV-2 Variants Can Predict Resistance to Monoclonal Antibodies, but Other Substitutions Can Modify the Effects
por: Lusvarghi, Sabrina, et al.
Publicado: (2022)

A Polyuridine Insertion in the 3′ Untranslated Region of Classical Swine Fever Virus Activates Immunity and Reduces Viral Virulence in Piglets
por: Wang, Miaomiao, et al.
Publicado: (2020)

Insight into Vaccine Development for Alphacoronaviruses Based on Structural and Immunological Analyses of Spike Proteins
por: Shi, Yuejun, et al.
Publicado: (2021)

Removal of the E(rns) RNase Activity and of the 3′ Untranslated Region Polyuridine Insertion in a Low-Virulence Classical Swine Fever Virus Triggers a Cytokine Storm and Lethal Disease
por: Wang, Miaomiao, et al.
Publicado: (2022)

Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex
por: Ha, Sha, et al.
Publicado: (2017)

Enhanced Cross-Reactive and Polyfunctional Effector-Memory T Cell Responses by ICVAX—a Human PD1-Based Bivalent HIV-1 Gag-p41 Mosaic DNA Vaccine
por: Chen, Samantha M. Y., et al.
Publicado: (2022)

Glycan Profiles of gp120 Protein Vaccines from Four Major HIV-1 Subtypes Produced from Different Host Cell Lines under Non-GMP or GMP Conditions
por: Wang, Shixia, et al.
Publicado: (2020)

Broadly Inhibiting Antineuraminidase Monoclonal Antibodies Induced by Trivalent Influenza Vaccine and H7N9 Infection in Humans
por: Rijal, Pramila, et al.
Publicado: (2020)

Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus
por: Zhang, Yuting, et al.
Publicado: (2022)

A bivalent β-carboline derivative inhibits macropinocytosis-dependent entry of pseudorabies virus by targeting the kinase DYRK1A
por: Wang, Chongyang, et al.
Publicado: (2023)

A Glycosylated RBD Protein Induces Enhanced Neutralizing Antibodies against Omicron and Other Variants with Improved Protection against SARS-CoV-2 Infection
por: Shi, Juan, et al.
Publicado: (2022)

A Heterologous Challenge Rescues the Attenuated Immunogenicity of SARS-CoV-2 Omicron BA.1 Variant in Syrian Hamster Model
por: Ma, Jian, et al.
Publicado: (2023)

A Novel Nanobody Targeting Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Receptor-Binding Domain Has Potent Cross-Neutralizing Activity and Protective Efficacy against MERS-CoV
por: Zhao, Guangyu, et al.
Publicado: (2018)

African Swine Fever Virus Bearing an I226R Gene Deletion Elicits Robust Immunity in Pigs to African Swine Fever
por: Zhang, Yanyan, et al.
Publicado: (2021)

Antigenicity and Immunogenicity of Differentially Glycosylated Hepatitis C Virus E2 Envelope Proteins Expressed in Mammalian and Insect Cells
por: Urbanowicz, Richard A., et al.
Publicado: (2019)

Equine-Origin Immunoglobulin Fragments Protect Nonhuman Primates from Ebola Virus Disease
por: Wang, Hualei, et al.
Publicado: (2019)

Targeting the Spike Receptor Binding Domain Class V Cryptic Epitope by an Antibody with Pan-Sarbecovirus Activity
por: Jensen, Jaime L., et al.
Publicado: (2023)

Cyclooxygenase-2 Facilitates Newcastle Disease Virus Proliferation and Is as a Target for Canthin-6-One Antiviral Activity
por: Wang, Chongyang, et al.
Publicado: (2020)

GSK3640254 Is a Novel HIV-1 Maturation Inhibitor with an Optimized Virology Profile
por: Dicker, Ira, et al.
Publicado: (2022)

Early Kinetics of the HLA Class I-Associated Peptidome of MVA.HIVconsv-Infected Cells
por: Ternette, Nicola, et al.
Publicado: (2015)

VP2 Exchange and NS3/NS3a Deletion in African Horse Sickness Virus (AHSV) in Development of Disabled Infectious Single Animal Vaccine Candidates for AHSV
por: van de Water, Sandra G. P., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_nvgdkj7r17oba8qm70ofpiupu8