Familial atrial fibrillation mutation M1875T-SCN5A increases early sodium current and dampens the effect of flecainide

AIMS: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Pathogenic variants in genes encoding ion channels are associated with familial AF. The point mutation M1875T in the SCN5A gene, which encodes the α-subunit of the cardiac sodium channel Na(v)1.5, has been associated with increase...

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Detalles Bibliográficos
Autores principales: O’Reilly, Molly, Sommerfeld, Laura C, O’Shea, C, Broadway-Stringer, S, Andaleeb, S, Reyat, J S, Kabir, S N, Stastny, D, Malinova, A, Delbue, D, Fortmueller, L, Gehmlich, K, Pavlovic, D, Skryabin, B V, Holmes, A P, Kirchhof, P, Fabritz, L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062360/
https://www.ncbi.nlm.nih.gov/pubmed/36504385
http://dx.doi.org/10.1093/europace/euac218

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