Cargando…

Association between use of psychotropic medications prior to SARS-COV-2 infection and trajectories of COVID-19 recovery: Findings from the prospective Predi-COVID cohort study

Psychological disturbances are frequent following COVID-19. However, there is not much information about whether pre-existing psychological disorders are associated with the severity and evolution of COVID-19. We aimed to explore the associations between regular psychotropic medication use (PM) befo...

Descripción completa

Detalles Bibliográficos
Autores principales: Aguayo, Gloria A., Fischer, Aurélie, Elbéji, Abir, Linn, Nyan, Ollert, Markus, Fagherazzi, Guy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062525/
https://www.ncbi.nlm.nih.gov/pubmed/37006590
http://dx.doi.org/10.3389/fpubh.2023.1055440
_version_ 1785017511913193472
author Aguayo, Gloria A.
Fischer, Aurélie
Elbéji, Abir
Linn, Nyan
Ollert, Markus
Fagherazzi, Guy
author_facet Aguayo, Gloria A.
Fischer, Aurélie
Elbéji, Abir
Linn, Nyan
Ollert, Markus
Fagherazzi, Guy
author_sort Aguayo, Gloria A.
collection PubMed
description Psychological disturbances are frequent following COVID-19. However, there is not much information about whether pre-existing psychological disorders are associated with the severity and evolution of COVID-19. We aimed to explore the associations between regular psychotropic medication use (PM) before infection as a proxy for mood or anxiety disorders with COVID-19 recovery trajectories. We used data from the Predi-COVID study. We followed adults, tested positive for SARS-CoV-2 and collected demographics, clinical characteristics, comorbidities and daily symptoms 14 days after inclusion. We calculated a score based on 16 symptoms and modeled latent class trajectories. We performed polynomial logistic regression with PM as primary exposure and the different trajectories as outcome. We included 791 participants, 51% were men, and 5.3% reported regular PM before infection. We identified four trajectories characterizing recovery dynamics: “Almost asymptomatic,” “Quick recovery,” “Slow recovery,” and “Persisting symptoms“. With a fully adjusted model for age, sex, socioeconomic, lifestyle and comorbidity, we observed associations between PM with the risks of being in more severe trajectories than “Almost Asymptomatic”: “Quick recovery” (relative risk (95% confidence intervals) 3.1 (2.7, 3.4), “Slow recovery” 5.2 (3.0, 9.2), and “Persisting symptoms“11.7 (6.9, 19.6) trajectories. We observed a gradient of risk between PM before the infection and the risk of slow or no recovery in the first 14 days. These results suggest that a pre-existing psychological condition increases the risk of a poorer evolution of COVID-19 and may increase the risk of Long COVID. Our findings can help to personalize the care of people with COVID-19.
format Online
Article
Text
id pubmed-10062525
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-100625252023-03-31 Association between use of psychotropic medications prior to SARS-COV-2 infection and trajectories of COVID-19 recovery: Findings from the prospective Predi-COVID cohort study Aguayo, Gloria A. Fischer, Aurélie Elbéji, Abir Linn, Nyan Ollert, Markus Fagherazzi, Guy Front Public Health Public Health Psychological disturbances are frequent following COVID-19. However, there is not much information about whether pre-existing psychological disorders are associated with the severity and evolution of COVID-19. We aimed to explore the associations between regular psychotropic medication use (PM) before infection as a proxy for mood or anxiety disorders with COVID-19 recovery trajectories. We used data from the Predi-COVID study. We followed adults, tested positive for SARS-CoV-2 and collected demographics, clinical characteristics, comorbidities and daily symptoms 14 days after inclusion. We calculated a score based on 16 symptoms and modeled latent class trajectories. We performed polynomial logistic regression with PM as primary exposure and the different trajectories as outcome. We included 791 participants, 51% were men, and 5.3% reported regular PM before infection. We identified four trajectories characterizing recovery dynamics: “Almost asymptomatic,” “Quick recovery,” “Slow recovery,” and “Persisting symptoms“. With a fully adjusted model for age, sex, socioeconomic, lifestyle and comorbidity, we observed associations between PM with the risks of being in more severe trajectories than “Almost Asymptomatic”: “Quick recovery” (relative risk (95% confidence intervals) 3.1 (2.7, 3.4), “Slow recovery” 5.2 (3.0, 9.2), and “Persisting symptoms“11.7 (6.9, 19.6) trajectories. We observed a gradient of risk between PM before the infection and the risk of slow or no recovery in the first 14 days. These results suggest that a pre-existing psychological condition increases the risk of a poorer evolution of COVID-19 and may increase the risk of Long COVID. Our findings can help to personalize the care of people with COVID-19. Frontiers Media S.A. 2023-03-16 /pmc/articles/PMC10062525/ /pubmed/37006590 http://dx.doi.org/10.3389/fpubh.2023.1055440 Text en Copyright © 2023 Aguayo, Fischer, Elbéji, Linn, Ollert and Fagherazzi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Aguayo, Gloria A.
Fischer, Aurélie
Elbéji, Abir
Linn, Nyan
Ollert, Markus
Fagherazzi, Guy
Association between use of psychotropic medications prior to SARS-COV-2 infection and trajectories of COVID-19 recovery: Findings from the prospective Predi-COVID cohort study
title Association between use of psychotropic medications prior to SARS-COV-2 infection and trajectories of COVID-19 recovery: Findings from the prospective Predi-COVID cohort study
title_full Association between use of psychotropic medications prior to SARS-COV-2 infection and trajectories of COVID-19 recovery: Findings from the prospective Predi-COVID cohort study
title_fullStr Association between use of psychotropic medications prior to SARS-COV-2 infection and trajectories of COVID-19 recovery: Findings from the prospective Predi-COVID cohort study
title_full_unstemmed Association between use of psychotropic medications prior to SARS-COV-2 infection and trajectories of COVID-19 recovery: Findings from the prospective Predi-COVID cohort study
title_short Association between use of psychotropic medications prior to SARS-COV-2 infection and trajectories of COVID-19 recovery: Findings from the prospective Predi-COVID cohort study
title_sort association between use of psychotropic medications prior to sars-cov-2 infection and trajectories of covid-19 recovery: findings from the prospective predi-covid cohort study
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062525/
https://www.ncbi.nlm.nih.gov/pubmed/37006590
http://dx.doi.org/10.3389/fpubh.2023.1055440
work_keys_str_mv AT aguayogloriaa associationbetweenuseofpsychotropicmedicationspriortosarscov2infectionandtrajectoriesofcovid19recoveryfindingsfromtheprospectivepredicovidcohortstudy
AT fischeraurelie associationbetweenuseofpsychotropicmedicationspriortosarscov2infectionandtrajectoriesofcovid19recoveryfindingsfromtheprospectivepredicovidcohortstudy
AT elbejiabir associationbetweenuseofpsychotropicmedicationspriortosarscov2infectionandtrajectoriesofcovid19recoveryfindingsfromtheprospectivepredicovidcohortstudy
AT linnnyan associationbetweenuseofpsychotropicmedicationspriortosarscov2infectionandtrajectoriesofcovid19recoveryfindingsfromtheprospectivepredicovidcohortstudy
AT ollertmarkus associationbetweenuseofpsychotropicmedicationspriortosarscov2infectionandtrajectoriesofcovid19recoveryfindingsfromtheprospectivepredicovidcohortstudy
AT fagherazziguy associationbetweenuseofpsychotropicmedicationspriortosarscov2infectionandtrajectoriesofcovid19recoveryfindingsfromtheprospectivepredicovidcohortstudy