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Chronic cough in post-COVID syndrome: Laryngeal electromyography findings in vagus nerve neuropathy

BACKGROUND: Despite being a new entity, there is a large amount of information on the characteristics of SARS-CoV-2 infection and the symptoms of the acute phase; however, there are still many unknowns about the clinical features and pathophysiology of post-COVID syndrome. Refractory chronic cough i...

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Autores principales: García-Vicente, Patricia, Rodríguez-Valiente, Antonio, Górriz Gil, Carmen, Márquez Altemir, Reyes, Martínez-Pérez, Francisco, López-Pajaro, Luis Fernando, García-Berrocal, Jose Ramón
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062549/
https://www.ncbi.nlm.nih.gov/pubmed/36996121
http://dx.doi.org/10.1371/journal.pone.0283758
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author García-Vicente, Patricia
Rodríguez-Valiente, Antonio
Górriz Gil, Carmen
Márquez Altemir, Reyes
Martínez-Pérez, Francisco
López-Pajaro, Luis Fernando
García-Berrocal, Jose Ramón
author_facet García-Vicente, Patricia
Rodríguez-Valiente, Antonio
Górriz Gil, Carmen
Márquez Altemir, Reyes
Martínez-Pérez, Francisco
López-Pajaro, Luis Fernando
García-Berrocal, Jose Ramón
author_sort García-Vicente, Patricia
collection PubMed
description BACKGROUND: Despite being a new entity, there is a large amount of information on the characteristics of SARS-CoV-2 infection and the symptoms of the acute phase; however, there are still many unknowns about the clinical features and pathophysiology of post-COVID syndrome. Refractory chronic cough is one of the most prevalent symptoms and carries both a medical problem and a social stigma. Many recent studies have highlighted the role of SARS-CoV-2 neurotropism, but no studies have demonstrated vagus nerve neuropathy as a cause of persistent chronic cough or other COVID-19 long-term effects. OBJECTIVE: The main objective was to assess the involvement of the vagus nerve neuropathy as a cause of chronic cough and other post-COVID syndrome symptoms. MATERIAL AND METHODS: This was a single-center observational study with prospective clinical data collected from 38 patients with chronic cough and post-COVID-19 syndrome. Clinical characteristics and laryngeal electromyographic findings were analyzed. RESULTS: Clinical data from 38 patients with chronic cough after 12 weeks of the acute phase of COVID-19 infection were analyzed. Of these patients, 81.6% suffered from other post-COVID conditions and, 73.6% reported fluctuating evolution of symptoms. Laryngeal electromyography (LEMG) of the thyroarytenoid (TA) muscles and cricothyroid (CT) muscles was pathological in 76.3% of the patients. Of the patients with abnormal LEMG, chronic denervation was the most frequent finding (82.8%), 10.3% presented acute denervation signs, and 6.9% presented myopathic pattern in LEMG. CONCLUSIONS: LEMG studies suggest the existence of postviral vagus nerve neuropathy after SARS-CoV-2 infection that could explain chronic cough in post-COVID syndrome.
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spelling pubmed-100625492023-03-31 Chronic cough in post-COVID syndrome: Laryngeal electromyography findings in vagus nerve neuropathy García-Vicente, Patricia Rodríguez-Valiente, Antonio Górriz Gil, Carmen Márquez Altemir, Reyes Martínez-Pérez, Francisco López-Pajaro, Luis Fernando García-Berrocal, Jose Ramón PLoS One Research Article BACKGROUND: Despite being a new entity, there is a large amount of information on the characteristics of SARS-CoV-2 infection and the symptoms of the acute phase; however, there are still many unknowns about the clinical features and pathophysiology of post-COVID syndrome. Refractory chronic cough is one of the most prevalent symptoms and carries both a medical problem and a social stigma. Many recent studies have highlighted the role of SARS-CoV-2 neurotropism, but no studies have demonstrated vagus nerve neuropathy as a cause of persistent chronic cough or other COVID-19 long-term effects. OBJECTIVE: The main objective was to assess the involvement of the vagus nerve neuropathy as a cause of chronic cough and other post-COVID syndrome symptoms. MATERIAL AND METHODS: This was a single-center observational study with prospective clinical data collected from 38 patients with chronic cough and post-COVID-19 syndrome. Clinical characteristics and laryngeal electromyographic findings were analyzed. RESULTS: Clinical data from 38 patients with chronic cough after 12 weeks of the acute phase of COVID-19 infection were analyzed. Of these patients, 81.6% suffered from other post-COVID conditions and, 73.6% reported fluctuating evolution of symptoms. Laryngeal electromyography (LEMG) of the thyroarytenoid (TA) muscles and cricothyroid (CT) muscles was pathological in 76.3% of the patients. Of the patients with abnormal LEMG, chronic denervation was the most frequent finding (82.8%), 10.3% presented acute denervation signs, and 6.9% presented myopathic pattern in LEMG. CONCLUSIONS: LEMG studies suggest the existence of postviral vagus nerve neuropathy after SARS-CoV-2 infection that could explain chronic cough in post-COVID syndrome. Public Library of Science 2023-03-30 /pmc/articles/PMC10062549/ /pubmed/36996121 http://dx.doi.org/10.1371/journal.pone.0283758 Text en © 2023 García-Vicente et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
García-Vicente, Patricia
Rodríguez-Valiente, Antonio
Górriz Gil, Carmen
Márquez Altemir, Reyes
Martínez-Pérez, Francisco
López-Pajaro, Luis Fernando
García-Berrocal, Jose Ramón
Chronic cough in post-COVID syndrome: Laryngeal electromyography findings in vagus nerve neuropathy
title Chronic cough in post-COVID syndrome: Laryngeal electromyography findings in vagus nerve neuropathy
title_full Chronic cough in post-COVID syndrome: Laryngeal electromyography findings in vagus nerve neuropathy
title_fullStr Chronic cough in post-COVID syndrome: Laryngeal electromyography findings in vagus nerve neuropathy
title_full_unstemmed Chronic cough in post-COVID syndrome: Laryngeal electromyography findings in vagus nerve neuropathy
title_short Chronic cough in post-COVID syndrome: Laryngeal electromyography findings in vagus nerve neuropathy
title_sort chronic cough in post-covid syndrome: laryngeal electromyography findings in vagus nerve neuropathy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062549/
https://www.ncbi.nlm.nih.gov/pubmed/36996121
http://dx.doi.org/10.1371/journal.pone.0283758
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