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Relation of urinary bisphenol concentration and diabetes or prediabetes in French adults: A cross-sectional study
BACKGROUND: International research has recently shown an association between exposure to bisphenol A (BPA) and the risk of diabetes, although limited results are available for exposure to bisphenol S (BPS) and bisphenol F (BPF). The aim of this study was to examine the relationships between impregna...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062552/ https://www.ncbi.nlm.nih.gov/pubmed/36996235 http://dx.doi.org/10.1371/journal.pone.0283444 |
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author | Delepierre, Julie Fosse-Edorh, Sandrine Fillol, Clémence Piffaretti, Clara |
author_facet | Delepierre, Julie Fosse-Edorh, Sandrine Fillol, Clémence Piffaretti, Clara |
author_sort | Delepierre, Julie |
collection | PubMed |
description | BACKGROUND: International research has recently shown an association between exposure to bisphenol A (BPA) and the risk of diabetes, although limited results are available for exposure to bisphenol S (BPS) and bisphenol F (BPF). The aim of this study was to examine the relationships between impregnation with BPA, BPS, and BPF and the prevalence of diabetes or prediabetes in the French adult population. METHODS: Based on the Esteban cross-sectional study, 852 adults aged 18 to 74 years living in France were included. To assess the link between urinary concentration of BPA, BPS and BPF and a state of dysglycemia (diabetes or prediabetes), logistic regression multivariable models were performed and adjusted for known risk factors for diabetes and urine creatinine concentration. RESULTS: The percentage of included individuals with diabetes or prediabetes was 17.8% (95% CI = [15.3–20.4]). Urinary BPA concentration was significantly higher in people with diabetes or prediabetes, independent of the known risk factors for diabetes (OR for an increase of 0.1 units in log-transformed concentration of BPA (μg/L) = 1.12; 95%CI = [1.05–1.19], p < 0.001). However, we did not find any significant independent association between urinary BPS and BPF levels and the prevalence of diabetes or prediabetes. CONCLUSIONS: In this sample, considering the diabetes risk factors, diabetes or prediabetes was positively associated with higher urinary BPA concentration but not with urinary BPS and BPF concentrations. However, analysis of prospective longitudinal studies are still necessary to demonstrate a causal link between bisphenol exposure and the risk of diabetes or prediabetes. |
format | Online Article Text |
id | pubmed-10062552 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-100625522023-03-31 Relation of urinary bisphenol concentration and diabetes or prediabetes in French adults: A cross-sectional study Delepierre, Julie Fosse-Edorh, Sandrine Fillol, Clémence Piffaretti, Clara PLoS One Research Article BACKGROUND: International research has recently shown an association between exposure to bisphenol A (BPA) and the risk of diabetes, although limited results are available for exposure to bisphenol S (BPS) and bisphenol F (BPF). The aim of this study was to examine the relationships between impregnation with BPA, BPS, and BPF and the prevalence of diabetes or prediabetes in the French adult population. METHODS: Based on the Esteban cross-sectional study, 852 adults aged 18 to 74 years living in France were included. To assess the link between urinary concentration of BPA, BPS and BPF and a state of dysglycemia (diabetes or prediabetes), logistic regression multivariable models were performed and adjusted for known risk factors for diabetes and urine creatinine concentration. RESULTS: The percentage of included individuals with diabetes or prediabetes was 17.8% (95% CI = [15.3–20.4]). Urinary BPA concentration was significantly higher in people with diabetes or prediabetes, independent of the known risk factors for diabetes (OR for an increase of 0.1 units in log-transformed concentration of BPA (μg/L) = 1.12; 95%CI = [1.05–1.19], p < 0.001). However, we did not find any significant independent association between urinary BPS and BPF levels and the prevalence of diabetes or prediabetes. CONCLUSIONS: In this sample, considering the diabetes risk factors, diabetes or prediabetes was positively associated with higher urinary BPA concentration but not with urinary BPS and BPF concentrations. However, analysis of prospective longitudinal studies are still necessary to demonstrate a causal link between bisphenol exposure and the risk of diabetes or prediabetes. Public Library of Science 2023-03-30 /pmc/articles/PMC10062552/ /pubmed/36996235 http://dx.doi.org/10.1371/journal.pone.0283444 Text en © 2023 Delepierre et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Delepierre, Julie Fosse-Edorh, Sandrine Fillol, Clémence Piffaretti, Clara Relation of urinary bisphenol concentration and diabetes or prediabetes in French adults: A cross-sectional study |
title | Relation of urinary bisphenol concentration and diabetes or prediabetes in French adults: A cross-sectional study |
title_full | Relation of urinary bisphenol concentration and diabetes or prediabetes in French adults: A cross-sectional study |
title_fullStr | Relation of urinary bisphenol concentration and diabetes or prediabetes in French adults: A cross-sectional study |
title_full_unstemmed | Relation of urinary bisphenol concentration and diabetes or prediabetes in French adults: A cross-sectional study |
title_short | Relation of urinary bisphenol concentration and diabetes or prediabetes in French adults: A cross-sectional study |
title_sort | relation of urinary bisphenol concentration and diabetes or prediabetes in french adults: a cross-sectional study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062552/ https://www.ncbi.nlm.nih.gov/pubmed/36996235 http://dx.doi.org/10.1371/journal.pone.0283444 |
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