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Desipramine enhances the stability of atherosclerotic plaque in rabbits monitored with molecular imaging

Acid sphingomyelinase (ASM) promotes atherogenesis and acute cardiovascular events. We previously demonstrated ASM inhibitor desipramine attenuated oxidized-LDL-induced macrophage apoptosis in vitro. Here, we aim to determine whether ASM-mediated apoptosis in plaque improves stability in vivo. In th...

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Detalles Bibliográficos
Autores principales:	Zhao, Min, You, Baiyang, Wang, Xiaole, Huang, Jin, Zhou, Ming, Shi, Ruizheng, Zhang, Guogang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062573/ https://www.ncbi.nlm.nih.gov/pubmed/36996033 http://dx.doi.org/10.1371/journal.pone.0283612

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