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Early warning indicators of HIV drug resistance in the southern highlands region of Tanzania: Lessons from a cross-sectional surveillance study
The World Health Organization early warning indicators (EWIs) permit surveillance of factors associated with the emergence of HIV drug resistance (HIVDR). We examined cross- and within-region performance on HIVDR EWIs for selected HIV care and treatment clinics (CTCs) in five regions of southern Tan...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062592/ https://www.ncbi.nlm.nih.gov/pubmed/36996096 http://dx.doi.org/10.1371/journal.pgph.0000929 |
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author | Khamadi, Samoel A. Mavere, Caroline Bahemana, Emmanuel Lwilla, Anange Mizinduko, Mucho Bwigane, Seth Peter, Adela Makando, Joy Peter, Benjamin Agaba, Patricia Shah, Neha Julu, Boniphase Ganesan, Kavitha Coakley, Peter Lee, Elizabeth H. |
author_facet | Khamadi, Samoel A. Mavere, Caroline Bahemana, Emmanuel Lwilla, Anange Mizinduko, Mucho Bwigane, Seth Peter, Adela Makando, Joy Peter, Benjamin Agaba, Patricia Shah, Neha Julu, Boniphase Ganesan, Kavitha Coakley, Peter Lee, Elizabeth H. |
author_sort | Khamadi, Samoel A. |
collection | PubMed |
description | The World Health Organization early warning indicators (EWIs) permit surveillance of factors associated with the emergence of HIV drug resistance (HIVDR). We examined cross- and within-region performance on HIVDR EWIs for selected HIV care and treatment clinics (CTCs) in five regions of southern Tanzania. We retrospectively abstracted EWI data from 50 CTCs for the January to December 2013 period. EWIs included the following: on time ART pick-up, retention on ART, ARV stockouts, and pharmacy prescribing and dispensing practices. Data for pediatric and adult people living with HIV were abstracted from source files, and frequencies and proportions were calculated for each EWI overall, as well as stratified by region, facility, and age group. Across and within all regions, on average, on-time pick-up of pills (63.0%), retention on ART (76.0%), and pharmacy stockouts (69.0%) were consistently poor for the pediatric population. Similarly, on-time pill pick up (66.0%), retention on ART (72.0%) and pharmacy stockouts (53.0%) for adults were also poor. By contrast, performance on pharmacy prescribing and dispensing practices were as desired for both pediatric and adult populations with few facility-level exceptions. In this study, regions and facilities in the southern highlands of Tanzania reported widespread presence of HIVDR risk factors, including sub-optimal timeliness of pill pickup, retention on ART, and drug stockouts. There is an urgent need to implement the WHO EWIs monitoring to minimize the emergence of preventable HIV drug resistance and to maintain the effectiveness of first and second-line ART regimens. This is particularly critical in the context of new ART drug roll-out such as dolutegravir during the COVID-19 pandemic when resultant HIV service disruptions require careful monitoring, and for virologic suppression as countries move closer to epidemic control. |
format | Online Article Text |
id | pubmed-10062592 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-100625922023-03-31 Early warning indicators of HIV drug resistance in the southern highlands region of Tanzania: Lessons from a cross-sectional surveillance study Khamadi, Samoel A. Mavere, Caroline Bahemana, Emmanuel Lwilla, Anange Mizinduko, Mucho Bwigane, Seth Peter, Adela Makando, Joy Peter, Benjamin Agaba, Patricia Shah, Neha Julu, Boniphase Ganesan, Kavitha Coakley, Peter Lee, Elizabeth H. PLOS Glob Public Health Research Article The World Health Organization early warning indicators (EWIs) permit surveillance of factors associated with the emergence of HIV drug resistance (HIVDR). We examined cross- and within-region performance on HIVDR EWIs for selected HIV care and treatment clinics (CTCs) in five regions of southern Tanzania. We retrospectively abstracted EWI data from 50 CTCs for the January to December 2013 period. EWIs included the following: on time ART pick-up, retention on ART, ARV stockouts, and pharmacy prescribing and dispensing practices. Data for pediatric and adult people living with HIV were abstracted from source files, and frequencies and proportions were calculated for each EWI overall, as well as stratified by region, facility, and age group. Across and within all regions, on average, on-time pick-up of pills (63.0%), retention on ART (76.0%), and pharmacy stockouts (69.0%) were consistently poor for the pediatric population. Similarly, on-time pill pick up (66.0%), retention on ART (72.0%) and pharmacy stockouts (53.0%) for adults were also poor. By contrast, performance on pharmacy prescribing and dispensing practices were as desired for both pediatric and adult populations with few facility-level exceptions. In this study, regions and facilities in the southern highlands of Tanzania reported widespread presence of HIVDR risk factors, including sub-optimal timeliness of pill pickup, retention on ART, and drug stockouts. There is an urgent need to implement the WHO EWIs monitoring to minimize the emergence of preventable HIV drug resistance and to maintain the effectiveness of first and second-line ART regimens. This is particularly critical in the context of new ART drug roll-out such as dolutegravir during the COVID-19 pandemic when resultant HIV service disruptions require careful monitoring, and for virologic suppression as countries move closer to epidemic control. Public Library of Science 2023-03-30 /pmc/articles/PMC10062592/ /pubmed/36996096 http://dx.doi.org/10.1371/journal.pgph.0000929 Text en https://creativecommons.org/publicdomain/zero/1.0/This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication. |
spellingShingle | Research Article Khamadi, Samoel A. Mavere, Caroline Bahemana, Emmanuel Lwilla, Anange Mizinduko, Mucho Bwigane, Seth Peter, Adela Makando, Joy Peter, Benjamin Agaba, Patricia Shah, Neha Julu, Boniphase Ganesan, Kavitha Coakley, Peter Lee, Elizabeth H. Early warning indicators of HIV drug resistance in the southern highlands region of Tanzania: Lessons from a cross-sectional surveillance study |
title | Early warning indicators of HIV drug resistance in the southern highlands region of Tanzania: Lessons from a cross-sectional surveillance study |
title_full | Early warning indicators of HIV drug resistance in the southern highlands region of Tanzania: Lessons from a cross-sectional surveillance study |
title_fullStr | Early warning indicators of HIV drug resistance in the southern highlands region of Tanzania: Lessons from a cross-sectional surveillance study |
title_full_unstemmed | Early warning indicators of HIV drug resistance in the southern highlands region of Tanzania: Lessons from a cross-sectional surveillance study |
title_short | Early warning indicators of HIV drug resistance in the southern highlands region of Tanzania: Lessons from a cross-sectional surveillance study |
title_sort | early warning indicators of hiv drug resistance in the southern highlands region of tanzania: lessons from a cross-sectional surveillance study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062592/ https://www.ncbi.nlm.nih.gov/pubmed/36996096 http://dx.doi.org/10.1371/journal.pgph.0000929 |
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