LALAPG variant of the Human Contraception Antibody (HCA) reduces Fc-mediated effector functions while maintaining sperm agglutination activity

High rates of unintended pregnancies worldwide indicate a need for more accessible and acceptable methods of contraception. We have developed a monoclonal antibody, the Human Contraception Antibody (HCA), for use by women in vaginal films and rings for contraception. The divalent F(ab’)2 region of H...

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Detalles Bibliográficos
Autores principales: Mausser, Emilie, Nador, Ellena, Politch, Joseph A., Pauly, Michael R., Marathe, Jai G., Moench, Thomas R., Zeitlin, Larry, Whaley, Kevin J., Anderson, Deborah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062632/
https://www.ncbi.nlm.nih.gov/pubmed/36996137
http://dx.doi.org/10.1371/journal.pone.0282147

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