Effects of PTH glandular and external dosing patterns on bone cell activity using a two-state receptor model—Implications for bone disease progression and treatment

Temporal aspects of ligand specificity have been shown to play a significant role in the case of pulsatile hormone secretion, as exemplified by parathyroid hormone (PTH) binding to its receptor (PTH1R), a G-protein-coupled receptor expressed on surfaces of osteoblasts and osteocytes. The latter bind...

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Detalles Bibliográficos
Autores principales: Martonová, Denisa, Lavaill, Maxence, Forwood, Mark R., Robling, Alexander, Cooper, David M. L., Leyendecker, Sigrid, Pivonka, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062658/
https://www.ncbi.nlm.nih.gov/pubmed/36996072
http://dx.doi.org/10.1371/journal.pone.0283544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062658/
https://www.ncbi.nlm.nih.gov/pubmed/36996072
http://dx.doi.org/10.1371/journal.pone.0283544

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