Cargando…

Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases

Chemokines belong to the family of cytokines with chemoattractant properties that regulate chemotaxis and leukocyte migration, as well as the induction of angiogenesis and maintenance of hemostasis. Curcumin, the major component of the Curcuma longa rhizome, has various pharmacological actions, incl...

Descripción completa

Detalles Bibliográficos
Autores principales: Sadeghi, Mahvash, Dehnavi, Sajad, Asadirad, Ali, Xu, Suowen, Majeed, Muhammed, Jamialahmadi, Tannaz, Johnston, Thomas P., Sahebkar, Amirhossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062691/
https://www.ncbi.nlm.nih.gov/pubmed/36997729
http://dx.doi.org/10.1007/s10787-023-01136-w
_version_ 1785017551906930688
author Sadeghi, Mahvash
Dehnavi, Sajad
Asadirad, Ali
Xu, Suowen
Majeed, Muhammed
Jamialahmadi, Tannaz
Johnston, Thomas P.
Sahebkar, Amirhossein
author_facet Sadeghi, Mahvash
Dehnavi, Sajad
Asadirad, Ali
Xu, Suowen
Majeed, Muhammed
Jamialahmadi, Tannaz
Johnston, Thomas P.
Sahebkar, Amirhossein
author_sort Sadeghi, Mahvash
collection PubMed
description Chemokines belong to the family of cytokines with chemoattractant properties that regulate chemotaxis and leukocyte migration, as well as the induction of angiogenesis and maintenance of hemostasis. Curcumin, the major component of the Curcuma longa rhizome, has various pharmacological actions, including anti-inflammatory, immune-regulatory, anti-oxidative, and lipid-modifying properties. Chemokines and chemokine receptors are influenced/modulated by curcumin. Thus, the current review focuses on the molecular mechanisms associated with curcumin's effects on chemoattractant cytokines, as well as putting into context the many studies that have reported curcumin-mediated regulatory effects on inflammatory conditions in the organs/systems of the body (e.g., the central nervous system, liver, and cardiovascular system). Curcumin's effects on viral and bacterial infections, cancer, and adverse pregnancy outcomes are also reviewed.
format Online
Article
Text
id pubmed-10062691
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-100626912023-03-31 Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases Sadeghi, Mahvash Dehnavi, Sajad Asadirad, Ali Xu, Suowen Majeed, Muhammed Jamialahmadi, Tannaz Johnston, Thomas P. Sahebkar, Amirhossein Inflammopharmacology Review Chemokines belong to the family of cytokines with chemoattractant properties that regulate chemotaxis and leukocyte migration, as well as the induction of angiogenesis and maintenance of hemostasis. Curcumin, the major component of the Curcuma longa rhizome, has various pharmacological actions, including anti-inflammatory, immune-regulatory, anti-oxidative, and lipid-modifying properties. Chemokines and chemokine receptors are influenced/modulated by curcumin. Thus, the current review focuses on the molecular mechanisms associated with curcumin's effects on chemoattractant cytokines, as well as putting into context the many studies that have reported curcumin-mediated regulatory effects on inflammatory conditions in the organs/systems of the body (e.g., the central nervous system, liver, and cardiovascular system). Curcumin's effects on viral and bacterial infections, cancer, and adverse pregnancy outcomes are also reviewed. Springer International Publishing 2023-03-30 2023 /pmc/articles/PMC10062691/ /pubmed/36997729 http://dx.doi.org/10.1007/s10787-023-01136-w Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Sadeghi, Mahvash
Dehnavi, Sajad
Asadirad, Ali
Xu, Suowen
Majeed, Muhammed
Jamialahmadi, Tannaz
Johnston, Thomas P.
Sahebkar, Amirhossein
Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases
title Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases
title_full Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases
title_fullStr Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases
title_full_unstemmed Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases
title_short Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases
title_sort curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062691/
https://www.ncbi.nlm.nih.gov/pubmed/36997729
http://dx.doi.org/10.1007/s10787-023-01136-w
work_keys_str_mv AT sadeghimahvash curcuminandchemokinesmechanismofactionandtherapeuticpotentialininflammatorydiseases
AT dehnavisajad curcuminandchemokinesmechanismofactionandtherapeuticpotentialininflammatorydiseases
AT asadiradali curcuminandchemokinesmechanismofactionandtherapeuticpotentialininflammatorydiseases
AT xusuowen curcuminandchemokinesmechanismofactionandtherapeuticpotentialininflammatorydiseases
AT majeedmuhammed curcuminandchemokinesmechanismofactionandtherapeuticpotentialininflammatorydiseases
AT jamialahmaditannaz curcuminandchemokinesmechanismofactionandtherapeuticpotentialininflammatorydiseases
AT johnstonthomasp curcuminandchemokinesmechanismofactionandtherapeuticpotentialininflammatorydiseases
AT sahebkaramirhossein curcuminandchemokinesmechanismofactionandtherapeuticpotentialininflammatorydiseases