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Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases
Chemokines belong to the family of cytokines with chemoattractant properties that regulate chemotaxis and leukocyte migration, as well as the induction of angiogenesis and maintenance of hemostasis. Curcumin, the major component of the Curcuma longa rhizome, has various pharmacological actions, incl...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062691/ https://www.ncbi.nlm.nih.gov/pubmed/36997729 http://dx.doi.org/10.1007/s10787-023-01136-w |
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author | Sadeghi, Mahvash Dehnavi, Sajad Asadirad, Ali Xu, Suowen Majeed, Muhammed Jamialahmadi, Tannaz Johnston, Thomas P. Sahebkar, Amirhossein |
author_facet | Sadeghi, Mahvash Dehnavi, Sajad Asadirad, Ali Xu, Suowen Majeed, Muhammed Jamialahmadi, Tannaz Johnston, Thomas P. Sahebkar, Amirhossein |
author_sort | Sadeghi, Mahvash |
collection | PubMed |
description | Chemokines belong to the family of cytokines with chemoattractant properties that regulate chemotaxis and leukocyte migration, as well as the induction of angiogenesis and maintenance of hemostasis. Curcumin, the major component of the Curcuma longa rhizome, has various pharmacological actions, including anti-inflammatory, immune-regulatory, anti-oxidative, and lipid-modifying properties. Chemokines and chemokine receptors are influenced/modulated by curcumin. Thus, the current review focuses on the molecular mechanisms associated with curcumin's effects on chemoattractant cytokines, as well as putting into context the many studies that have reported curcumin-mediated regulatory effects on inflammatory conditions in the organs/systems of the body (e.g., the central nervous system, liver, and cardiovascular system). Curcumin's effects on viral and bacterial infections, cancer, and adverse pregnancy outcomes are also reviewed. |
format | Online Article Text |
id | pubmed-10062691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-100626912023-03-31 Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases Sadeghi, Mahvash Dehnavi, Sajad Asadirad, Ali Xu, Suowen Majeed, Muhammed Jamialahmadi, Tannaz Johnston, Thomas P. Sahebkar, Amirhossein Inflammopharmacology Review Chemokines belong to the family of cytokines with chemoattractant properties that regulate chemotaxis and leukocyte migration, as well as the induction of angiogenesis and maintenance of hemostasis. Curcumin, the major component of the Curcuma longa rhizome, has various pharmacological actions, including anti-inflammatory, immune-regulatory, anti-oxidative, and lipid-modifying properties. Chemokines and chemokine receptors are influenced/modulated by curcumin. Thus, the current review focuses on the molecular mechanisms associated with curcumin's effects on chemoattractant cytokines, as well as putting into context the many studies that have reported curcumin-mediated regulatory effects on inflammatory conditions in the organs/systems of the body (e.g., the central nervous system, liver, and cardiovascular system). Curcumin's effects on viral and bacterial infections, cancer, and adverse pregnancy outcomes are also reviewed. Springer International Publishing 2023-03-30 2023 /pmc/articles/PMC10062691/ /pubmed/36997729 http://dx.doi.org/10.1007/s10787-023-01136-w Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Sadeghi, Mahvash Dehnavi, Sajad Asadirad, Ali Xu, Suowen Majeed, Muhammed Jamialahmadi, Tannaz Johnston, Thomas P. Sahebkar, Amirhossein Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases |
title | Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases |
title_full | Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases |
title_fullStr | Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases |
title_full_unstemmed | Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases |
title_short | Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases |
title_sort | curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062691/ https://www.ncbi.nlm.nih.gov/pubmed/36997729 http://dx.doi.org/10.1007/s10787-023-01136-w |
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