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Treponema pallidum subsp. pallidum with an Artificially impaired TprK antigenic variation system is attenuated in the Rabbit model of syphilis

BACKGROUND: The TprK protein of the syphilis agent, Treponema pallidum subsp. pallidum (T. pallidum), undergoes antigenic variation in seven discrete variable (V) regions via non-reciprocal segmental gene conversion. These recombination events transfer information from a repertoire of 53 silent chro...

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Detalles Bibliográficos
Autores principales:	Romeis, Emily, Lieberman, Nicole A. P., Molini, Barbara, Tantalo, Lauren C., Chung, Benjamin, Phung, Quynh, Avendaño, Carlos, Vorobieva, Anastassia, Greninger, Alexander L., Giacani, Lorenzo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063172/ https://www.ncbi.nlm.nih.gov/pubmed/36940224 http://dx.doi.org/10.1371/journal.ppat.1011259

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