Cargando…

Unhealthy lifestyle impacts on biological systems involved in stress response: hypothalamic–pituitary–adrenal axis, inflammation and autonomous nervous system

An unhealthy lifestyle has a critical role in the pathogenesis and course of several chronic disorders. It has been hypothesized that lifestyle may also impact biological systems involved in stress response. A global index of unhealthy lifestyle was calculated based on the cumulative presence of fiv...

Descripción completa

Detalles Bibliográficos
Autores principales: Mandelli, Laura, Milaneschi, Yuri, Hiles, Sarah, Serretti, Alessandro, Penninx, Brenda W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams And Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063190/
https://www.ncbi.nlm.nih.gov/pubmed/36730700
http://dx.doi.org/10.1097/YIC.0000000000000437
_version_ 1785017657784795136
author Mandelli, Laura
Milaneschi, Yuri
Hiles, Sarah
Serretti, Alessandro
Penninx, Brenda W.
author_facet Mandelli, Laura
Milaneschi, Yuri
Hiles, Sarah
Serretti, Alessandro
Penninx, Brenda W.
author_sort Mandelli, Laura
collection PubMed
description An unhealthy lifestyle has a critical role in the pathogenesis and course of several chronic disorders. It has been hypothesized that lifestyle may also impact biological systems involved in stress response. A global index of unhealthy lifestyle was calculated based on the cumulative presence of five self-reported lifestyle habits (smoking, excessive alcohol use, drug use, low physical activity and short sleep) in 2783 participants (18–65 years) from the Netherlands Study of Depression and Anxiety. The functioning of biological stress systems was based on multiple physiological measures of cortisol, inflammatory cytokines and autonomic cardiac activity. The unhealthy lifestyle index was associated with hyperactivity of hypothalamus–pituitary–adrenal axis and increased inflammation, indicating that with increasing unhealthy habits, the level of biological stress increases. No association with the autonomic nervous system activity was observed; however, the use of drugs increased parasympathetic cardiac activity and significantly impacted on ANS. Results were not impacted by a recent episode of depression or anxiety disorder. An unhealthy lifestyle may unfavorably impact on biological systems involved in stress response, which may underlie progression of several psychiatric as well as somatic chronic disorders.
format Online
Article
Text
id pubmed-10063190
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Lippincott Williams And Wilkins
record_format MEDLINE/PubMed
spelling pubmed-100631902023-03-31 Unhealthy lifestyle impacts on biological systems involved in stress response: hypothalamic–pituitary–adrenal axis, inflammation and autonomous nervous system Mandelli, Laura Milaneschi, Yuri Hiles, Sarah Serretti, Alessandro Penninx, Brenda W. Int Clin Psychopharmacol Original Articles An unhealthy lifestyle has a critical role in the pathogenesis and course of several chronic disorders. It has been hypothesized that lifestyle may also impact biological systems involved in stress response. A global index of unhealthy lifestyle was calculated based on the cumulative presence of five self-reported lifestyle habits (smoking, excessive alcohol use, drug use, low physical activity and short sleep) in 2783 participants (18–65 years) from the Netherlands Study of Depression and Anxiety. The functioning of biological stress systems was based on multiple physiological measures of cortisol, inflammatory cytokines and autonomic cardiac activity. The unhealthy lifestyle index was associated with hyperactivity of hypothalamus–pituitary–adrenal axis and increased inflammation, indicating that with increasing unhealthy habits, the level of biological stress increases. No association with the autonomic nervous system activity was observed; however, the use of drugs increased parasympathetic cardiac activity and significantly impacted on ANS. Results were not impacted by a recent episode of depression or anxiety disorder. An unhealthy lifestyle may unfavorably impact on biological systems involved in stress response, which may underlie progression of several psychiatric as well as somatic chronic disorders. Lippincott Williams And Wilkins 2022-11-11 2023-05 /pmc/articles/PMC10063190/ /pubmed/36730700 http://dx.doi.org/10.1097/YIC.0000000000000437 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Mandelli, Laura
Milaneschi, Yuri
Hiles, Sarah
Serretti, Alessandro
Penninx, Brenda W.
Unhealthy lifestyle impacts on biological systems involved in stress response: hypothalamic–pituitary–adrenal axis, inflammation and autonomous nervous system
title Unhealthy lifestyle impacts on biological systems involved in stress response: hypothalamic–pituitary–adrenal axis, inflammation and autonomous nervous system
title_full Unhealthy lifestyle impacts on biological systems involved in stress response: hypothalamic–pituitary–adrenal axis, inflammation and autonomous nervous system
title_fullStr Unhealthy lifestyle impacts on biological systems involved in stress response: hypothalamic–pituitary–adrenal axis, inflammation and autonomous nervous system
title_full_unstemmed Unhealthy lifestyle impacts on biological systems involved in stress response: hypothalamic–pituitary–adrenal axis, inflammation and autonomous nervous system
title_short Unhealthy lifestyle impacts on biological systems involved in stress response: hypothalamic–pituitary–adrenal axis, inflammation and autonomous nervous system
title_sort unhealthy lifestyle impacts on biological systems involved in stress response: hypothalamic–pituitary–adrenal axis, inflammation and autonomous nervous system
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063190/
https://www.ncbi.nlm.nih.gov/pubmed/36730700
http://dx.doi.org/10.1097/YIC.0000000000000437
work_keys_str_mv AT mandellilaura unhealthylifestyleimpactsonbiologicalsystemsinvolvedinstressresponsehypothalamicpituitaryadrenalaxisinflammationandautonomousnervoussystem
AT milaneschiyuri unhealthylifestyleimpactsonbiologicalsystemsinvolvedinstressresponsehypothalamicpituitaryadrenalaxisinflammationandautonomousnervoussystem
AT hilessarah unhealthylifestyleimpactsonbiologicalsystemsinvolvedinstressresponsehypothalamicpituitaryadrenalaxisinflammationandautonomousnervoussystem
AT serrettialessandro unhealthylifestyleimpactsonbiologicalsystemsinvolvedinstressresponsehypothalamicpituitaryadrenalaxisinflammationandautonomousnervoussystem
AT penninxbrendaw unhealthylifestyleimpactsonbiologicalsystemsinvolvedinstressresponsehypothalamicpituitaryadrenalaxisinflammationandautonomousnervoussystem