Cargando…

Central metabolites and peripheral parameters associated neuroinflammation in fibromyalgia patients: A preliminary study

To identify central metabolites and peripheral measures associated with neuroinflammation in fibromyalgia (FM), we scanned [(11)C]-(R)-PK11195 positron emission tomography and magnetic resonance spectroscopy in FM patients. We measured associations between neurometabolite levels measured by magnetic...

Descripción completa

Detalles Bibliográficos
Autores principales: Jung, Ye-Ha, Kim, Hyeonjin, Seo, Seongho, Lee, Dasom, Lee, Jae-Yeon, Moon, Jee Youn, Cheon, Gi Jeong, Choi, Soo-Hee, Kang, Do-Hyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063264/
https://www.ncbi.nlm.nih.gov/pubmed/37000093
http://dx.doi.org/10.1097/MD.0000000000033305
_version_ 1785017674226466816
author Jung, Ye-Ha
Kim, Hyeonjin
Seo, Seongho
Lee, Dasom
Lee, Jae-Yeon
Moon, Jee Youn
Cheon, Gi Jeong
Choi, Soo-Hee
Kang, Do-Hyung
author_facet Jung, Ye-Ha
Kim, Hyeonjin
Seo, Seongho
Lee, Dasom
Lee, Jae-Yeon
Moon, Jee Youn
Cheon, Gi Jeong
Choi, Soo-Hee
Kang, Do-Hyung
author_sort Jung, Ye-Ha
collection PubMed
description To identify central metabolites and peripheral measures associated with neuroinflammation in fibromyalgia (FM), we scanned [(11)C]-(R)-PK11195 positron emission tomography and magnetic resonance spectroscopy in FM patients. We measured associations between neurometabolite levels measured by magnetic resonance spectroscopy and the extent of neuroinflammation inferred by the distribution volume ratios of [(11)C]-(R)-PK11195 positron emission tomography in 12 FM patients and 13 healthy controls. We also examined the associations between peripheral parameters, such as creatinine and C-reactive protein, and neuroinflammation. In FM patients, we found negative correlations between neuroinflammation and the creatine (Cr)/total creatine (tCr; Cr + phosphocreatine) ratios in the right (r = −0.708, P = .015) and left thalamus (r = −0.718, P = .008). In FM patients, negative correlations were apparent between neuroinflammation and the glutamate/tCr ratio in the right insula (r = −0.746, P = .005). In FM patients, we found negative correlations between neuroinflammation in the left thalamus (r = –0.601, P = .039) and left insula (r = −0.598, P = .040) and the blood creatinine levels. Additionally, we found significant correlations of other peripheral measures with neuroinflammation in FM patients. Our results suggest that both central metabolites, such as Cr and glutamate, and peripheral creatinine and other parameters are associated with neuroinflammation in patients with FM.
format Online
Article
Text
id pubmed-10063264
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-100632642023-03-31 Central metabolites and peripheral parameters associated neuroinflammation in fibromyalgia patients: A preliminary study Jung, Ye-Ha Kim, Hyeonjin Seo, Seongho Lee, Dasom Lee, Jae-Yeon Moon, Jee Youn Cheon, Gi Jeong Choi, Soo-Hee Kang, Do-Hyung Medicine (Baltimore) 5300 To identify central metabolites and peripheral measures associated with neuroinflammation in fibromyalgia (FM), we scanned [(11)C]-(R)-PK11195 positron emission tomography and magnetic resonance spectroscopy in FM patients. We measured associations between neurometabolite levels measured by magnetic resonance spectroscopy and the extent of neuroinflammation inferred by the distribution volume ratios of [(11)C]-(R)-PK11195 positron emission tomography in 12 FM patients and 13 healthy controls. We also examined the associations between peripheral parameters, such as creatinine and C-reactive protein, and neuroinflammation. In FM patients, we found negative correlations between neuroinflammation and the creatine (Cr)/total creatine (tCr; Cr + phosphocreatine) ratios in the right (r = −0.708, P = .015) and left thalamus (r = −0.718, P = .008). In FM patients, negative correlations were apparent between neuroinflammation and the glutamate/tCr ratio in the right insula (r = −0.746, P = .005). In FM patients, we found negative correlations between neuroinflammation in the left thalamus (r = –0.601, P = .039) and left insula (r = −0.598, P = .040) and the blood creatinine levels. Additionally, we found significant correlations of other peripheral measures with neuroinflammation in FM patients. Our results suggest that both central metabolites, such as Cr and glutamate, and peripheral creatinine and other parameters are associated with neuroinflammation in patients with FM. Lippincott Williams & Wilkins 2023-03-31 /pmc/articles/PMC10063264/ /pubmed/37000093 http://dx.doi.org/10.1097/MD.0000000000033305 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5300
Jung, Ye-Ha
Kim, Hyeonjin
Seo, Seongho
Lee, Dasom
Lee, Jae-Yeon
Moon, Jee Youn
Cheon, Gi Jeong
Choi, Soo-Hee
Kang, Do-Hyung
Central metabolites and peripheral parameters associated neuroinflammation in fibromyalgia patients: A preliminary study
title Central metabolites and peripheral parameters associated neuroinflammation in fibromyalgia patients: A preliminary study
title_full Central metabolites and peripheral parameters associated neuroinflammation in fibromyalgia patients: A preliminary study
title_fullStr Central metabolites and peripheral parameters associated neuroinflammation in fibromyalgia patients: A preliminary study
title_full_unstemmed Central metabolites and peripheral parameters associated neuroinflammation in fibromyalgia patients: A preliminary study
title_short Central metabolites and peripheral parameters associated neuroinflammation in fibromyalgia patients: A preliminary study
title_sort central metabolites and peripheral parameters associated neuroinflammation in fibromyalgia patients: a preliminary study
topic 5300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063264/
https://www.ncbi.nlm.nih.gov/pubmed/37000093
http://dx.doi.org/10.1097/MD.0000000000033305
work_keys_str_mv AT jungyeha centralmetabolitesandperipheralparametersassociatedneuroinflammationinfibromyalgiapatientsapreliminarystudy
AT kimhyeonjin centralmetabolitesandperipheralparametersassociatedneuroinflammationinfibromyalgiapatientsapreliminarystudy
AT seoseongho centralmetabolitesandperipheralparametersassociatedneuroinflammationinfibromyalgiapatientsapreliminarystudy
AT leedasom centralmetabolitesandperipheralparametersassociatedneuroinflammationinfibromyalgiapatientsapreliminarystudy
AT leejaeyeon centralmetabolitesandperipheralparametersassociatedneuroinflammationinfibromyalgiapatientsapreliminarystudy
AT moonjeeyoun centralmetabolitesandperipheralparametersassociatedneuroinflammationinfibromyalgiapatientsapreliminarystudy
AT cheongijeong centralmetabolitesandperipheralparametersassociatedneuroinflammationinfibromyalgiapatientsapreliminarystudy
AT choisoohee centralmetabolitesandperipheralparametersassociatedneuroinflammationinfibromyalgiapatientsapreliminarystudy
AT kangdohyung centralmetabolitesandperipheralparametersassociatedneuroinflammationinfibromyalgiapatientsapreliminarystudy