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Central metabolites and peripheral parameters associated neuroinflammation in fibromyalgia patients: A preliminary study
To identify central metabolites and peripheral measures associated with neuroinflammation in fibromyalgia (FM), we scanned [(11)C]-(R)-PK11195 positron emission tomography and magnetic resonance spectroscopy in FM patients. We measured associations between neurometabolite levels measured by magnetic...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063264/ https://www.ncbi.nlm.nih.gov/pubmed/37000093 http://dx.doi.org/10.1097/MD.0000000000033305 |
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author | Jung, Ye-Ha Kim, Hyeonjin Seo, Seongho Lee, Dasom Lee, Jae-Yeon Moon, Jee Youn Cheon, Gi Jeong Choi, Soo-Hee Kang, Do-Hyung |
author_facet | Jung, Ye-Ha Kim, Hyeonjin Seo, Seongho Lee, Dasom Lee, Jae-Yeon Moon, Jee Youn Cheon, Gi Jeong Choi, Soo-Hee Kang, Do-Hyung |
author_sort | Jung, Ye-Ha |
collection | PubMed |
description | To identify central metabolites and peripheral measures associated with neuroinflammation in fibromyalgia (FM), we scanned [(11)C]-(R)-PK11195 positron emission tomography and magnetic resonance spectroscopy in FM patients. We measured associations between neurometabolite levels measured by magnetic resonance spectroscopy and the extent of neuroinflammation inferred by the distribution volume ratios of [(11)C]-(R)-PK11195 positron emission tomography in 12 FM patients and 13 healthy controls. We also examined the associations between peripheral parameters, such as creatinine and C-reactive protein, and neuroinflammation. In FM patients, we found negative correlations between neuroinflammation and the creatine (Cr)/total creatine (tCr; Cr + phosphocreatine) ratios in the right (r = −0.708, P = .015) and left thalamus (r = −0.718, P = .008). In FM patients, negative correlations were apparent between neuroinflammation and the glutamate/tCr ratio in the right insula (r = −0.746, P = .005). In FM patients, we found negative correlations between neuroinflammation in the left thalamus (r = –0.601, P = .039) and left insula (r = −0.598, P = .040) and the blood creatinine levels. Additionally, we found significant correlations of other peripheral measures with neuroinflammation in FM patients. Our results suggest that both central metabolites, such as Cr and glutamate, and peripheral creatinine and other parameters are associated with neuroinflammation in patients with FM. |
format | Online Article Text |
id | pubmed-10063264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-100632642023-03-31 Central metabolites and peripheral parameters associated neuroinflammation in fibromyalgia patients: A preliminary study Jung, Ye-Ha Kim, Hyeonjin Seo, Seongho Lee, Dasom Lee, Jae-Yeon Moon, Jee Youn Cheon, Gi Jeong Choi, Soo-Hee Kang, Do-Hyung Medicine (Baltimore) 5300 To identify central metabolites and peripheral measures associated with neuroinflammation in fibromyalgia (FM), we scanned [(11)C]-(R)-PK11195 positron emission tomography and magnetic resonance spectroscopy in FM patients. We measured associations between neurometabolite levels measured by magnetic resonance spectroscopy and the extent of neuroinflammation inferred by the distribution volume ratios of [(11)C]-(R)-PK11195 positron emission tomography in 12 FM patients and 13 healthy controls. We also examined the associations between peripheral parameters, such as creatinine and C-reactive protein, and neuroinflammation. In FM patients, we found negative correlations between neuroinflammation and the creatine (Cr)/total creatine (tCr; Cr + phosphocreatine) ratios in the right (r = −0.708, P = .015) and left thalamus (r = −0.718, P = .008). In FM patients, negative correlations were apparent between neuroinflammation and the glutamate/tCr ratio in the right insula (r = −0.746, P = .005). In FM patients, we found negative correlations between neuroinflammation in the left thalamus (r = –0.601, P = .039) and left insula (r = −0.598, P = .040) and the blood creatinine levels. Additionally, we found significant correlations of other peripheral measures with neuroinflammation in FM patients. Our results suggest that both central metabolites, such as Cr and glutamate, and peripheral creatinine and other parameters are associated with neuroinflammation in patients with FM. Lippincott Williams & Wilkins 2023-03-31 /pmc/articles/PMC10063264/ /pubmed/37000093 http://dx.doi.org/10.1097/MD.0000000000033305 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | 5300 Jung, Ye-Ha Kim, Hyeonjin Seo, Seongho Lee, Dasom Lee, Jae-Yeon Moon, Jee Youn Cheon, Gi Jeong Choi, Soo-Hee Kang, Do-Hyung Central metabolites and peripheral parameters associated neuroinflammation in fibromyalgia patients: A preliminary study |
title | Central metabolites and peripheral parameters associated neuroinflammation in fibromyalgia patients: A preliminary study |
title_full | Central metabolites and peripheral parameters associated neuroinflammation in fibromyalgia patients: A preliminary study |
title_fullStr | Central metabolites and peripheral parameters associated neuroinflammation in fibromyalgia patients: A preliminary study |
title_full_unstemmed | Central metabolites and peripheral parameters associated neuroinflammation in fibromyalgia patients: A preliminary study |
title_short | Central metabolites and peripheral parameters associated neuroinflammation in fibromyalgia patients: A preliminary study |
title_sort | central metabolites and peripheral parameters associated neuroinflammation in fibromyalgia patients: a preliminary study |
topic | 5300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063264/ https://www.ncbi.nlm.nih.gov/pubmed/37000093 http://dx.doi.org/10.1097/MD.0000000000033305 |
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