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Neurochemical Biomarkers in patients with COVID-19

The limited data available on CSF analysis in patients with COVID-19 prompted us to conduct a large-scale multicenter study on behalf of the German Society for CSF Diagnostics and Clinical Neurochemistry (DGLN), taking into account a wide range of parameters, including white blood cell count (WCC) i...

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Autor principal: Tumani, Hayrettin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063367/
http://dx.doi.org/10.1016/j.jadr.2023.100573
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author Tumani, Hayrettin
author_facet Tumani, Hayrettin
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description The limited data available on CSF analysis in patients with COVID-19 prompted us to conduct a large-scale multicenter study on behalf of the German Society for CSF Diagnostics and Clinical Neurochemistry (DGLN), taking into account a wide range of parameters, including white blood cell count (WCC) in CSF and cytology, quantitative and qualitative detection of intrathecal IgG, IgM and IgA synthesis, markers of blood CSF barrier (BCB) dysfunction, total protein, lactate, glucose and SARS-CoV-2 CSF polymerase chain reaction (PCR), antibody indices (AI), autoantibody findings and cytokine levels. CSF findings from 150 lumbar punctures in 127 patients with PCR-proven COVID-19 and neurologic symptoms showed that direct CNS infection with SARS-CoV-2 appears to be rare. The major findings were BCB dysfunction in the absence of intrathecal inflammation consistent with cerebrospinal endotheliopathy and a decrease in CSF flow rate. Cytokine levels were frequently elevated in CSF (often in association with BCB dysfunction) and serum. Persistent BCB dysfunction and elevated cytokine levels may contribute to both acute symptoms and "long COVID." Further analysis of COVID-19 patients with longitudinal data is warranted.
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spelling pubmed-100633672023-03-31 Neurochemical Biomarkers in patients with COVID-19 Tumani, Hayrettin J Affect Disord Rep Article The limited data available on CSF analysis in patients with COVID-19 prompted us to conduct a large-scale multicenter study on behalf of the German Society for CSF Diagnostics and Clinical Neurochemistry (DGLN), taking into account a wide range of parameters, including white blood cell count (WCC) in CSF and cytology, quantitative and qualitative detection of intrathecal IgG, IgM and IgA synthesis, markers of blood CSF barrier (BCB) dysfunction, total protein, lactate, glucose and SARS-CoV-2 CSF polymerase chain reaction (PCR), antibody indices (AI), autoantibody findings and cytokine levels. CSF findings from 150 lumbar punctures in 127 patients with PCR-proven COVID-19 and neurologic symptoms showed that direct CNS infection with SARS-CoV-2 appears to be rare. The major findings were BCB dysfunction in the absence of intrathecal inflammation consistent with cerebrospinal endotheliopathy and a decrease in CSF flow rate. Cytokine levels were frequently elevated in CSF (often in association with BCB dysfunction) and serum. Persistent BCB dysfunction and elevated cytokine levels may contribute to both acute symptoms and "long COVID." Further analysis of COVID-19 patients with longitudinal data is warranted. Published by Elsevier B.V. 2023-04 2023-03-31 /pmc/articles/PMC10063367/ http://dx.doi.org/10.1016/j.jadr.2023.100573 Text en Copyright © 2023 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Tumani, Hayrettin
Neurochemical Biomarkers in patients with COVID-19
title Neurochemical Biomarkers in patients with COVID-19
title_full Neurochemical Biomarkers in patients with COVID-19
title_fullStr Neurochemical Biomarkers in patients with COVID-19
title_full_unstemmed Neurochemical Biomarkers in patients with COVID-19
title_short Neurochemical Biomarkers in patients with COVID-19
title_sort neurochemical biomarkers in patients with covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063367/
http://dx.doi.org/10.1016/j.jadr.2023.100573
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