Targeting the E3 ligase NEDD4 as a novel therapeutic strategy for IGF1 signal pathway-driven gastric cancer

The IGF1 signal pathway is highly activated in some subtype of gastric cancer(GC) that exhibits poor survival and chemotherapy resistance. Although the results of clinical trials of anti-IGF1R monoclonal antibodies and IGF-1R inhibitors have been mostly disappointing in unselected cancer patients, s...

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Detalles Bibliográficos
Autores principales: Wang, Ke, Yu, Yanping, Wang, Wei, Jiang, Yu, Li, Yunlong, Jiang, Xunliang, Qiao, Yihuan, Chen, Le, Zhao, Xinhui, Liu, Jun, Yang, Angang, Li, Jipeng, Zhang, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063445/
https://www.ncbi.nlm.nih.gov/pubmed/36774408
http://dx.doi.org/10.1038/s41388-023-02619-4

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