Cargando…

Exhausted intratumoral Vδ2(−) γδ T cells in human kidney cancer retain effector function

Gamma delta (γδ) T cells reside within human tissues including tumors, but their function in mediating antitumor responses to immune checkpoint inhibition is unknown. Here we show that kidney cancers are infiltrated by Vδ2(−) γδ T cells, with equivalent representation of Vδ1(+) and Vδ1(−) cells, tha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rancan, Chiara, Arias-Badia, Marcel, Dogra, Pranay, Chen, Brandon, Aran, Dvir, Yang, Hai, Luong, Diamond, Ilano, Arielle, Li, Jacky, Chang, Hewitt, Kwek, Serena S., Zhang, Li, Lanier, Lewis L., Meng, Maxwell V., Farber, Donna L., Fong, Lawrence
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063448/ https://www.ncbi.nlm.nih.gov/pubmed/36928415 http://dx.doi.org/10.1038/s41590-023-01448-7

Ejemplares similares

Intratumoral CD4(+) T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer
por: Oh, David Y., et al.
Publicado: (2020)

Inversion of the Vδ1 to Vδ2 γδ T cell ratio in CVID is not restored by IVIg and is associated with immune activation and exhaustion
por: Paquin-Proulx, Dominic, et al.
Publicado: (2016)

γδ T cell exhaustion: Opportunities for intervention
por: Chen, Di, et al.
Publicado: (2022)

Inversion of the Vδ1 to Vδ2 γδ T cell ratio in CVID is not restored by IVIg and is associated with immune activation and exhaustion: Erratum
Publicado: (2017)

Intratumor heterogeneity and T cell exhaustion in primary CNS lymphoma
por: Heming, Michael, et al.
Publicado: (2022)

Human Vδ2 versus non-Vδ2 γδ T cells in antitumor immunity
por: Kabelitz, Dieter, et al.
Publicado: (2013)

Phenotype and regulation of immunosuppressive Vδ2-expressing γδ T cells
por: Peters, Christian, et al.
Publicado: (2013)

Hepatocellular carcinoma‐infiltrating γδ T cells are functionally defected and allogenic Vδ2(+) γδ T cell can be a promising complement
por: He, Wenjing, et al.
Publicado: (2022)

Higher frequency of circulating Vδ1 γδT cells in patients with advanced schistosomiasis
por: Zheng, Li, et al.
Publicado: (2021)

Distinct phenotype and function of circulating Vδ1(+) and Vδ2(+) γδT-cells in acute and chronic hepatitis B
por: Chang, Kyong-Mi, et al.
Publicado: (2019)

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma
por: Murai, Hiroki, et al.
Publicado: (2023)

Role of Vγ9Vδ2+ γδ T cells in juvenile idiopathic arthritis
por: Gerstein, M, et al.
Publicado: (2008)

Flow Cytometric Pattern of TCRVδ Subtype Expression Rapidly Identifies γδT Cell Lymphoma
por: Chen, Xiao, et al.
Publicado: (2020)

Suppression of CEBPδ recovers exhaustion in anti-metastatic immune cells
por: Yin, Chenxue, et al.
Publicado: (2023)

CMV-Independent Lysis of Glioblastoma by Ex Vivo Expanded/Activated Vδ1+ γδ T Cells
por: Knight, Andrea, et al.
Publicado: (2013)

Human Peripheral CD4(+) Vδ1(+) γδT Cells Can Develop into αβT Cells
por: Ziegler, Hendrik, et al.
Publicado: (2014)

Potential Role of Vδ2(+) γδ T Cells in Regulation of Immune Activation in Primary HIV Infection
por: Bhatnagar, Nupur, et al.
Publicado: (2017)

Circulating monocytes associated with anti-PD-1 resistance in human biliary cancer induce T cell paralysis
por: Keenan, Bridget P., et al.
Publicado: (2022)

Human αβ and γδ T Cells in Skin Immunity and Disease
por: Cruz, Michelle S., et al.
Publicado: (2018)

High Abundance of Intratumoral γδ T Cells Favors a Better Prognosis in Head and Neck Squamous Cell Carcinoma: A Bioinformatic Analysis
por: Lu, Huanzi, et al.
Publicado: (2020)

Expression of LAG-3 defines exhaustion of intratumoral PD-1(+) T cells and correlates with poor outcome in follicular lymphoma
por: Yang, Zhi-Zhang, et al.
Publicado: (2017)

Essential and Partially Overlapping Role of CD3γ and CD3δ for Development of αβ and γδ T Lymphocytes
por: Wang, Baoping, et al.
Publicado: (1998)

Genetic Influence on the Peripheral Differentiation Signature of Vδ2+ γδ and CD4+ αβ T Cells in Adults
por: Beucke, Nicola, et al.
Publicado: (2021)

A CMV-induced adaptive human Vδ1(+) γδ T cell clone recognizes HLA-DR
por: Deseke, Malte, et al.
Publicado: (2022)

Vaccine protection by Cryptococcus neoformans Δsgl1 is mediated by γδ T cells via TLR2 signaling
por: Normile, Tyler G., et al.
Publicado: (2022)

Targeting Melanoma-Associated Fibroblasts (MAFs) with Activated γδ (Vδ2) T Cells: An In Vitro Cytotoxicity Model
por: Hajdara, Anna, et al.
Publicado: (2023)

Cytomegalovirus drives Vδ2(neg) γδ T cell inflation in many healthy virus carriers with increasing age
por: Alejenef, A, et al.
Publicado: (2014)

Unique and Common Features of Innate-Like Human Vδ2(+) γδT Cells and Mucosal-Associated Invariant T Cells
por: Provine, Nicholas M., et al.
Publicado: (2018)

Association of Decreased Percentage of Vδ2(+)Vγ9(+) γδ T Cells With Disease Severity in Multiple Sclerosis
por: Maimaitijiang, Guzailiayi, et al.
Publicado: (2018)

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance
por: Davey, Martin S., et al.
Publicado: (2017)

Suppressive activity of Vδ2(+) γδ T cells on αβ T cells is licensed by TCR signaling and correlates with signal strength
por: Schilbach, Karin, et al.
Publicado: (2020)

Circulating PD1(+)Vδ1(+)γδ T Cell Predicts Fertility in Endometrial Polyp Patients of Reproductive-Age
por: Li, Xiao-Hong, et al.
Publicado: (2021)

The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy
por: Legut, Mateusz, et al.
Publicado: (2015)

Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation
por: Muro, Ryunosuke, et al.
Publicado: (2023)

Interleukin‐17‐producing γδ T (γδ17) cells in inflammatory diseases
por: Akitsu, Aoi, et al.
Publicado: (2018)

Shared reactivity of Vδ2(neg) γδ T cells against cytomegalovirus-infected cells and tumor intestinal epithelial cells
por: Halary, Franck, et al.
Publicado: (2005)

Human CD3γ, but not CD3δ, haploinsufficiency differentially impairs γδ versus αβ surface TCR expression
por: Muñoz-Ruiz, Miguel, et al.
Publicado: (2013)

Δ42PD1-TLR4 Augments γδ-T Cell Activation of the Transitional Memory Subset of CD4(+) T Cells
por: Mo, Yufei, et al.
Publicado: (2020)

A Simple and Robust Single-Step Method for CAR-Vδ1 γδT Cell Expansion and Transduction for Cancer Immunotherapy
por: Ferry, Gabrielle M., et al.
Publicado: (2022)

Long-term use of interferon-β in multiple sclerosis increases Vδ1(−)Vδ2(−)Vγ9(−) γδ T cells that are associated with a better outcome
por: Maimaitijiang, Guzailiayi, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_eoq6ejps01t7va6vmmsovg0dip