A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function

Mature T cells must discriminate between brief interactions with self-peptides and prolonged binding to agonists. The kinetic proofreading model posits that certain T-cell antigen receptor signaling nodes serve as molecular timers to facilitate such discrimination. However, the physiological signifi...

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Detalles Bibliográficos
Autores principales: Lo, Wan-Lin, Kuhlmann, Miriam, Rizzuto, Gabrielle, Ekiz, H. Atakan, Kolawole, Elizabeth M., Revelo, Monica P., Andargachew, Rakieb, Li, Zhongmei, Tsai, Yuan-Li, Marson, Alexander, Evavold, Brian D., Zehn, Dietmar, Weiss, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063449/
https://www.ncbi.nlm.nih.gov/pubmed/36914891
http://dx.doi.org/10.1038/s41590-023-01444-x

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