Cargando…
Survival in patients with surgically treated brain metastases: does infratentorial location matter?
Surgical resection is a common treatment modality for brain metastasis (BM). Location of the BM might significantly impact patient survival and therefore might be considered in clinical decision making and patient counseling. In the present study, the authors analyzed infra- and supratentorial BM lo...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063486/ https://www.ncbi.nlm.nih.gov/pubmed/36997703 http://dx.doi.org/10.1007/s10143-023-01986-6 |
_version_ | 1785017716239761408 |
---|---|
author | Hamed, Motaz Potthoff, Anna-Laura Heimann, Muriel Schäfer, Niklas Borger, Valeri Radbruch, Alexander Herrlinger, Ulrich Vatter, Hartmut Schneider, Matthias |
author_facet | Hamed, Motaz Potthoff, Anna-Laura Heimann, Muriel Schäfer, Niklas Borger, Valeri Radbruch, Alexander Herrlinger, Ulrich Vatter, Hartmut Schneider, Matthias |
author_sort | Hamed, Motaz |
collection | PubMed |
description | Surgical resection is a common treatment modality for brain metastasis (BM). Location of the BM might significantly impact patient survival and therefore might be considered in clinical decision making and patient counseling. In the present study, the authors analyzed infra- and supratentorial BM location for a potential prognostic difference. Between 2013 and 2019, 245 patients with solitary BM received BM resection at the authors’ neuro-oncological center. In order to produce a covariate balance for commonly-known prognostic variables (tumor entity, age, preoperative Karnofsky Performance Score, and preoperative Charlson Comorbidity Index), a propensity score matching at a ratio of 1:1 between the cohort of patients with infra- and supratentorial BM location was performed using R. Overall survival (OS) rates were assessed for both matched cohorts of patients with BM. Sixty-one of 245 patients (25%) with solitary BM exhibited an infratentorial tumor location; 184 patients (75%) suffered from supratentorial solitary BM. Patients with infratentorial BM revealed a median OS of 11 months (95% confidence interval (CI) 7.4–14.6 months). Compared with this, median OS for the group of 61 individually matched patients with solitary supratentorial solitary BM was 13 months (95% CI 10.9-15.1 months) (p = 0.32). The present study suggests that the prognostic value of infra- and supratentorial BMs does not significantly differ in patients that undergo surgery for solitary BM. These results might encourage physicians to induce surgical therapy of supra- and infratentorial BM in a similar manner. |
format | Online Article Text |
id | pubmed-10063486 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-100634862023-04-01 Survival in patients with surgically treated brain metastases: does infratentorial location matter? Hamed, Motaz Potthoff, Anna-Laura Heimann, Muriel Schäfer, Niklas Borger, Valeri Radbruch, Alexander Herrlinger, Ulrich Vatter, Hartmut Schneider, Matthias Neurosurg Rev Research Surgical resection is a common treatment modality for brain metastasis (BM). Location of the BM might significantly impact patient survival and therefore might be considered in clinical decision making and patient counseling. In the present study, the authors analyzed infra- and supratentorial BM location for a potential prognostic difference. Between 2013 and 2019, 245 patients with solitary BM received BM resection at the authors’ neuro-oncological center. In order to produce a covariate balance for commonly-known prognostic variables (tumor entity, age, preoperative Karnofsky Performance Score, and preoperative Charlson Comorbidity Index), a propensity score matching at a ratio of 1:1 between the cohort of patients with infra- and supratentorial BM location was performed using R. Overall survival (OS) rates were assessed for both matched cohorts of patients with BM. Sixty-one of 245 patients (25%) with solitary BM exhibited an infratentorial tumor location; 184 patients (75%) suffered from supratentorial solitary BM. Patients with infratentorial BM revealed a median OS of 11 months (95% confidence interval (CI) 7.4–14.6 months). Compared with this, median OS for the group of 61 individually matched patients with solitary supratentorial solitary BM was 13 months (95% CI 10.9-15.1 months) (p = 0.32). The present study suggests that the prognostic value of infra- and supratentorial BMs does not significantly differ in patients that undergo surgery for solitary BM. These results might encourage physicians to induce surgical therapy of supra- and infratentorial BM in a similar manner. Springer Berlin Heidelberg 2023-03-30 2023 /pmc/articles/PMC10063486/ /pubmed/36997703 http://dx.doi.org/10.1007/s10143-023-01986-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Hamed, Motaz Potthoff, Anna-Laura Heimann, Muriel Schäfer, Niklas Borger, Valeri Radbruch, Alexander Herrlinger, Ulrich Vatter, Hartmut Schneider, Matthias Survival in patients with surgically treated brain metastases: does infratentorial location matter? |
title | Survival in patients with surgically treated brain metastases: does infratentorial location matter? |
title_full | Survival in patients with surgically treated brain metastases: does infratentorial location matter? |
title_fullStr | Survival in patients with surgically treated brain metastases: does infratentorial location matter? |
title_full_unstemmed | Survival in patients with surgically treated brain metastases: does infratentorial location matter? |
title_short | Survival in patients with surgically treated brain metastases: does infratentorial location matter? |
title_sort | survival in patients with surgically treated brain metastases: does infratentorial location matter? |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063486/ https://www.ncbi.nlm.nih.gov/pubmed/36997703 http://dx.doi.org/10.1007/s10143-023-01986-6 |
work_keys_str_mv | AT hamedmotaz survivalinpatientswithsurgicallytreatedbrainmetastasesdoesinfratentoriallocationmatter AT potthoffannalaura survivalinpatientswithsurgicallytreatedbrainmetastasesdoesinfratentoriallocationmatter AT heimannmuriel survivalinpatientswithsurgicallytreatedbrainmetastasesdoesinfratentoriallocationmatter AT schaferniklas survivalinpatientswithsurgicallytreatedbrainmetastasesdoesinfratentoriallocationmatter AT borgervaleri survivalinpatientswithsurgicallytreatedbrainmetastasesdoesinfratentoriallocationmatter AT radbruchalexander survivalinpatientswithsurgicallytreatedbrainmetastasesdoesinfratentoriallocationmatter AT herrlingerulrich survivalinpatientswithsurgicallytreatedbrainmetastasesdoesinfratentoriallocationmatter AT vatterhartmut survivalinpatientswithsurgicallytreatedbrainmetastasesdoesinfratentoriallocationmatter AT schneidermatthias survivalinpatientswithsurgicallytreatedbrainmetastasesdoesinfratentoriallocationmatter |