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Intrinsic neural timescales in autism spectrum disorder and schizophrenia. A replication and direct comparison study

Intrinsic neural timescales (INT) reflect the duration for which brain areas store information. A posterior–anterior hierarchy of increasingly longer INT has been revealed in both typically developed individuals (TD), as well as persons diagnosed with autism spectrum disorder (ASD) and schizophrenia...

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Autores principales: Uscătescu, Lavinia Carmen, Kronbichler, Martin, Said-Yürekli, Sarah, Kronbichler, Lisa, Calhoun, Vince, Corbera, Silvia, Bell, Morris, Pelphrey, Kevin, Pearlson, Godfrey, Assaf, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063601/
https://www.ncbi.nlm.nih.gov/pubmed/36997542
http://dx.doi.org/10.1038/s41537-023-00344-1
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author Uscătescu, Lavinia Carmen
Kronbichler, Martin
Said-Yürekli, Sarah
Kronbichler, Lisa
Calhoun, Vince
Corbera, Silvia
Bell, Morris
Pelphrey, Kevin
Pearlson, Godfrey
Assaf, Michal
author_facet Uscătescu, Lavinia Carmen
Kronbichler, Martin
Said-Yürekli, Sarah
Kronbichler, Lisa
Calhoun, Vince
Corbera, Silvia
Bell, Morris
Pelphrey, Kevin
Pearlson, Godfrey
Assaf, Michal
author_sort Uscătescu, Lavinia Carmen
collection PubMed
description Intrinsic neural timescales (INT) reflect the duration for which brain areas store information. A posterior–anterior hierarchy of increasingly longer INT has been revealed in both typically developed individuals (TD), as well as persons diagnosed with autism spectrum disorder (ASD) and schizophrenia (SZ), though INT are, overall, shorter in both patient groups. In the present study, we aimed to replicate previously reported group differences by comparing INT of TD to ASD and SZ. We partially replicated the previously reported result, showing reduced INT in the left lateral occipital gyrus and the right post-central gyrus in SZ compared to TD. We also directly compared the INT of the two patient groups and found that these same two areas show significantly reduced INT in SZ compared to ASD. Previously reported correlations between INT and symptom severity were not replicated in the current project. Our findings serve to circumscribe the brain areas that can potentially play a determinant role in observed sensory peculiarities in ASD and SZ.
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spelling pubmed-100636012023-04-01 Intrinsic neural timescales in autism spectrum disorder and schizophrenia. A replication and direct comparison study Uscătescu, Lavinia Carmen Kronbichler, Martin Said-Yürekli, Sarah Kronbichler, Lisa Calhoun, Vince Corbera, Silvia Bell, Morris Pelphrey, Kevin Pearlson, Godfrey Assaf, Michal Schizophrenia (Heidelb) Article Intrinsic neural timescales (INT) reflect the duration for which brain areas store information. A posterior–anterior hierarchy of increasingly longer INT has been revealed in both typically developed individuals (TD), as well as persons diagnosed with autism spectrum disorder (ASD) and schizophrenia (SZ), though INT are, overall, shorter in both patient groups. In the present study, we aimed to replicate previously reported group differences by comparing INT of TD to ASD and SZ. We partially replicated the previously reported result, showing reduced INT in the left lateral occipital gyrus and the right post-central gyrus in SZ compared to TD. We also directly compared the INT of the two patient groups and found that these same two areas show significantly reduced INT in SZ compared to ASD. Previously reported correlations between INT and symptom severity were not replicated in the current project. Our findings serve to circumscribe the brain areas that can potentially play a determinant role in observed sensory peculiarities in ASD and SZ. Nature Publishing Group UK 2023-03-30 /pmc/articles/PMC10063601/ /pubmed/36997542 http://dx.doi.org/10.1038/s41537-023-00344-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Uscătescu, Lavinia Carmen
Kronbichler, Martin
Said-Yürekli, Sarah
Kronbichler, Lisa
Calhoun, Vince
Corbera, Silvia
Bell, Morris
Pelphrey, Kevin
Pearlson, Godfrey
Assaf, Michal
Intrinsic neural timescales in autism spectrum disorder and schizophrenia. A replication and direct comparison study
title Intrinsic neural timescales in autism spectrum disorder and schizophrenia. A replication and direct comparison study
title_full Intrinsic neural timescales in autism spectrum disorder and schizophrenia. A replication and direct comparison study
title_fullStr Intrinsic neural timescales in autism spectrum disorder and schizophrenia. A replication and direct comparison study
title_full_unstemmed Intrinsic neural timescales in autism spectrum disorder and schizophrenia. A replication and direct comparison study
title_short Intrinsic neural timescales in autism spectrum disorder and schizophrenia. A replication and direct comparison study
title_sort intrinsic neural timescales in autism spectrum disorder and schizophrenia. a replication and direct comparison study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063601/
https://www.ncbi.nlm.nih.gov/pubmed/36997542
http://dx.doi.org/10.1038/s41537-023-00344-1
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