Discovery of novel cardiac troponin activators using fluorescence polarization-based high throughput screening assays

The large unmet demand for new heart failure therapeutics is widely acknowledged. Over the last decades the contractile myofilaments themselves have emerged as an attractive target for the development of new therapeutics for both systolic and diastolic heart failure. However, the clinical use of myo...

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Detalles Bibliográficos
Autores principales: Parijat, Priyanka, Ponnam, Saraswathi, Attili, Seetharamaiah, Campbell, Kenneth S., El-Mezgueldi, Mohammed, Pfuhl, Mark, Kampourakis, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063609/
https://www.ncbi.nlm.nih.gov/pubmed/36997544
http://dx.doi.org/10.1038/s41598-023-32476-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063609/
https://www.ncbi.nlm.nih.gov/pubmed/36997544
http://dx.doi.org/10.1038/s41598-023-32476-w

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