Cytosine base editors induce off-target mutations and adverse phenotypic effects in transgenic mice

Base editors have been reported to induce off-target mutations in cultured cells, mouse embryos and rice, but their long-term effects in vivo remain unknown. Here, we develop a Systematic evaluation Approach For gene Editing tools by Transgenic mIce (SAFETI), and evaluate the off-target effects of B...

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Detalles Bibliográficos
Autores principales: Yan, Nana, Feng, Hu, Sun, Yongsen, Xin, Ying, Zhang, Haihang, Lu, Hongjiang, Zheng, Jitan, He, Chenfei, Zuo, Zhenrui, Yuan, Tanglong, Li, Nana, Xie, Long, Wei, Wu, Sun, Yidi, Zuo, Erwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063651/
https://www.ncbi.nlm.nih.gov/pubmed/36997536
http://dx.doi.org/10.1038/s41467-023-37508-7

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