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Evasion strategies of porcine reproductive and respiratory syndrome virus
During the co-evolution of viruses and their hosts, viruses have developed various strategies for overcoming host immunological defenses so that they can proliferate efficiently. Porcine reproductive and respiratory syndrome virus (PRRSV), a significant virus to the swine industry across the world,...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063791/ https://www.ncbi.nlm.nih.gov/pubmed/37007469 http://dx.doi.org/10.3389/fmicb.2023.1140449 |
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author | Chen, Xin-xin Qiao, Songlin Li, Rui Wang, Jing Li, Xuewu Zhang, Gaiping |
author_facet | Chen, Xin-xin Qiao, Songlin Li, Rui Wang, Jing Li, Xuewu Zhang, Gaiping |
author_sort | Chen, Xin-xin |
collection | PubMed |
description | During the co-evolution of viruses and their hosts, viruses have developed various strategies for overcoming host immunological defenses so that they can proliferate efficiently. Porcine reproductive and respiratory syndrome virus (PRRSV), a significant virus to the swine industry across the world, typically establishes prolonged infection via diverse and complicated mechanisms, which is one of the biggest obstacles for controlling the associated disease, porcine reproductive and respiratory syndrome (PRRS). In this review, we summarize the latest research on how PRRSV circumvents host antiviral responses from both the innate and adaptive immune systems and how this virus utilizes other evasion mechanisms, such as the manipulation of host apoptosis and microRNA. A thorough understanding of the exact mechanisms of PRRSV immune evasion will help with the development of novel antiviral strategies against PRRSV. |
format | Online Article Text |
id | pubmed-10063791 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100637912023-04-01 Evasion strategies of porcine reproductive and respiratory syndrome virus Chen, Xin-xin Qiao, Songlin Li, Rui Wang, Jing Li, Xuewu Zhang, Gaiping Front Microbiol Microbiology During the co-evolution of viruses and their hosts, viruses have developed various strategies for overcoming host immunological defenses so that they can proliferate efficiently. Porcine reproductive and respiratory syndrome virus (PRRSV), a significant virus to the swine industry across the world, typically establishes prolonged infection via diverse and complicated mechanisms, which is one of the biggest obstacles for controlling the associated disease, porcine reproductive and respiratory syndrome (PRRS). In this review, we summarize the latest research on how PRRSV circumvents host antiviral responses from both the innate and adaptive immune systems and how this virus utilizes other evasion mechanisms, such as the manipulation of host apoptosis and microRNA. A thorough understanding of the exact mechanisms of PRRSV immune evasion will help with the development of novel antiviral strategies against PRRSV. Frontiers Media S.A. 2023-03-17 /pmc/articles/PMC10063791/ /pubmed/37007469 http://dx.doi.org/10.3389/fmicb.2023.1140449 Text en Copyright © 2023 Chen, Qiao, Li, Wang, Li and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Chen, Xin-xin Qiao, Songlin Li, Rui Wang, Jing Li, Xuewu Zhang, Gaiping Evasion strategies of porcine reproductive and respiratory syndrome virus |
title | Evasion strategies of porcine reproductive and respiratory syndrome virus |
title_full | Evasion strategies of porcine reproductive and respiratory syndrome virus |
title_fullStr | Evasion strategies of porcine reproductive and respiratory syndrome virus |
title_full_unstemmed | Evasion strategies of porcine reproductive and respiratory syndrome virus |
title_short | Evasion strategies of porcine reproductive and respiratory syndrome virus |
title_sort | evasion strategies of porcine reproductive and respiratory syndrome virus |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063791/ https://www.ncbi.nlm.nih.gov/pubmed/37007469 http://dx.doi.org/10.3389/fmicb.2023.1140449 |
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