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Case report: Immune remission from generalized myasthenia gravis in a dog with a thymoma and cholangiocellular carcinoma
A 9-year-old male neutered Cockapoo was presented with an acute and progressive history of exercise induced weakness involving all limbs, and bilateral decreased ability to blink. Investigations revealed generalized myasthenia gravis alongside the presence of a thymoma and a cholangiocellular carcin...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063851/ https://www.ncbi.nlm.nih.gov/pubmed/37008354 http://dx.doi.org/10.3389/fvets.2023.1124702 |
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author | Mignan, Thomas White, Robert Stee, Kimberley Bonanno, Giuseppe Targett, Mike Lowrie, Mark |
author_facet | Mignan, Thomas White, Robert Stee, Kimberley Bonanno, Giuseppe Targett, Mike Lowrie, Mark |
author_sort | Mignan, Thomas |
collection | PubMed |
description | A 9-year-old male neutered Cockapoo was presented with an acute and progressive history of exercise induced weakness involving all limbs, and bilateral decreased ability to blink. Investigations revealed generalized myasthenia gravis alongside the presence of a thymoma and a cholangiocellular carcinoma. Symptomatic treatment through pyridostigmine bromide was used to control clinical signs, and complete surgical removal of the thymoma and cholangiocellular carcinoma was performed. Serum acetylcholine receptor antibody concentration was measured serially. Clinical remission defined as resolution of clinical signs alongside discontinuation of treatment was achieved by day 251 (8.2 months). Immune remission defined as normalization of serum acetylcholine receptor antibody concentration alongside resolution of clinical signs and discontinuation of treatment was achieved by day 566 (18.5 months). Neurological examination was normal, and the owners did not report any clinical deterioration during the final follow-up appointment on day 752 (24 months), hence outcome was considered excellent. This is the first report describing the temporal evolution of serum acetylcholine receptor antibody concentration in a dog with thymoma-associated myasthenia gravis which achieved immune remission following thymectomy. Treatment was successfully discontinued without any evidence of clinical deterioration thereafter despite serum acetylcholine receptor antibody concentration not normalizing for another 315 days (10 months). |
format | Online Article Text |
id | pubmed-10063851 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100638512023-04-01 Case report: Immune remission from generalized myasthenia gravis in a dog with a thymoma and cholangiocellular carcinoma Mignan, Thomas White, Robert Stee, Kimberley Bonanno, Giuseppe Targett, Mike Lowrie, Mark Front Vet Sci Veterinary Science A 9-year-old male neutered Cockapoo was presented with an acute and progressive history of exercise induced weakness involving all limbs, and bilateral decreased ability to blink. Investigations revealed generalized myasthenia gravis alongside the presence of a thymoma and a cholangiocellular carcinoma. Symptomatic treatment through pyridostigmine bromide was used to control clinical signs, and complete surgical removal of the thymoma and cholangiocellular carcinoma was performed. Serum acetylcholine receptor antibody concentration was measured serially. Clinical remission defined as resolution of clinical signs alongside discontinuation of treatment was achieved by day 251 (8.2 months). Immune remission defined as normalization of serum acetylcholine receptor antibody concentration alongside resolution of clinical signs and discontinuation of treatment was achieved by day 566 (18.5 months). Neurological examination was normal, and the owners did not report any clinical deterioration during the final follow-up appointment on day 752 (24 months), hence outcome was considered excellent. This is the first report describing the temporal evolution of serum acetylcholine receptor antibody concentration in a dog with thymoma-associated myasthenia gravis which achieved immune remission following thymectomy. Treatment was successfully discontinued without any evidence of clinical deterioration thereafter despite serum acetylcholine receptor antibody concentration not normalizing for another 315 days (10 months). Frontiers Media S.A. 2023-03-17 /pmc/articles/PMC10063851/ /pubmed/37008354 http://dx.doi.org/10.3389/fvets.2023.1124702 Text en Copyright © 2023 Mignan, White, Stee, Bonanno, Targett and Lowrie. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Veterinary Science Mignan, Thomas White, Robert Stee, Kimberley Bonanno, Giuseppe Targett, Mike Lowrie, Mark Case report: Immune remission from generalized myasthenia gravis in a dog with a thymoma and cholangiocellular carcinoma |
title | Case report: Immune remission from generalized myasthenia gravis in a dog with a thymoma and cholangiocellular carcinoma |
title_full | Case report: Immune remission from generalized myasthenia gravis in a dog with a thymoma and cholangiocellular carcinoma |
title_fullStr | Case report: Immune remission from generalized myasthenia gravis in a dog with a thymoma and cholangiocellular carcinoma |
title_full_unstemmed | Case report: Immune remission from generalized myasthenia gravis in a dog with a thymoma and cholangiocellular carcinoma |
title_short | Case report: Immune remission from generalized myasthenia gravis in a dog with a thymoma and cholangiocellular carcinoma |
title_sort | case report: immune remission from generalized myasthenia gravis in a dog with a thymoma and cholangiocellular carcinoma |
topic | Veterinary Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063851/ https://www.ncbi.nlm.nih.gov/pubmed/37008354 http://dx.doi.org/10.3389/fvets.2023.1124702 |
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