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Understanding the background and clinical significance of the WHO, WOAH, and EMA classifications of antimicrobials to mitigate antimicrobial resistance

In Europe, the classification systems of the WHO, WOAH (founded as OIE), and EMA are the prevailing standard documents guiding the prudent use of antibiotic substances. While the WHO document “Critically important antimicrobials for human medicine” eponymously focusses on the use in humans, the othe...

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Autores principales: Gehring, Ronette, Mochel, Jonathan P., Schmerold, Ivo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063873/
https://www.ncbi.nlm.nih.gov/pubmed/37008341
http://dx.doi.org/10.3389/fvets.2023.1153048
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author Gehring, Ronette
Mochel, Jonathan P.
Schmerold, Ivo
author_facet Gehring, Ronette
Mochel, Jonathan P.
Schmerold, Ivo
author_sort Gehring, Ronette
collection PubMed
description In Europe, the classification systems of the WHO, WOAH (founded as OIE), and EMA are the prevailing standard documents guiding the prudent use of antibiotic substances. While the WHO document “Critically important antimicrobials for human medicine” eponymously focusses on the use in humans, the other two documents, “OIE List of Antimicrobial Agents of Veterinary Importance” and “EMA Categorization of antibiotics for use in animals,” concentrate exclusively on the prudent use of antibiotics in animals. One common purpose of these classification systems is to provide guidance in making sound decisions on the choice of antibiotics for treating humans as well as animals. Although the latest editions of these compendia refer to one another and bear a clear resemblance at the category levels, some of the substances are grouped into unequal classes. This review illustrates the specific perspectives of the three categorization systems under consideration. The arguments raised for different classifications between the WHO and the EMA are exemplified for amoxicillins without beta-lactamase inhibitors, macrolides, sulfonamides, and colistin. For the daily clinical use of antibiotics, veterinarians should consider the EMA document, and, under tentative circumstances, consult the OIE list.
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spelling pubmed-100638732023-04-01 Understanding the background and clinical significance of the WHO, WOAH, and EMA classifications of antimicrobials to mitigate antimicrobial resistance Gehring, Ronette Mochel, Jonathan P. Schmerold, Ivo Front Vet Sci Veterinary Science In Europe, the classification systems of the WHO, WOAH (founded as OIE), and EMA are the prevailing standard documents guiding the prudent use of antibiotic substances. While the WHO document “Critically important antimicrobials for human medicine” eponymously focusses on the use in humans, the other two documents, “OIE List of Antimicrobial Agents of Veterinary Importance” and “EMA Categorization of antibiotics for use in animals,” concentrate exclusively on the prudent use of antibiotics in animals. One common purpose of these classification systems is to provide guidance in making sound decisions on the choice of antibiotics for treating humans as well as animals. Although the latest editions of these compendia refer to one another and bear a clear resemblance at the category levels, some of the substances are grouped into unequal classes. This review illustrates the specific perspectives of the three categorization systems under consideration. The arguments raised for different classifications between the WHO and the EMA are exemplified for amoxicillins without beta-lactamase inhibitors, macrolides, sulfonamides, and colistin. For the daily clinical use of antibiotics, veterinarians should consider the EMA document, and, under tentative circumstances, consult the OIE list. Frontiers Media S.A. 2023-03-17 /pmc/articles/PMC10063873/ /pubmed/37008341 http://dx.doi.org/10.3389/fvets.2023.1153048 Text en Copyright © 2023 Gehring, Mochel and Schmerold. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Gehring, Ronette
Mochel, Jonathan P.
Schmerold, Ivo
Understanding the background and clinical significance of the WHO, WOAH, and EMA classifications of antimicrobials to mitigate antimicrobial resistance
title Understanding the background and clinical significance of the WHO, WOAH, and EMA classifications of antimicrobials to mitigate antimicrobial resistance
title_full Understanding the background and clinical significance of the WHO, WOAH, and EMA classifications of antimicrobials to mitigate antimicrobial resistance
title_fullStr Understanding the background and clinical significance of the WHO, WOAH, and EMA classifications of antimicrobials to mitigate antimicrobial resistance
title_full_unstemmed Understanding the background and clinical significance of the WHO, WOAH, and EMA classifications of antimicrobials to mitigate antimicrobial resistance
title_short Understanding the background and clinical significance of the WHO, WOAH, and EMA classifications of antimicrobials to mitigate antimicrobial resistance
title_sort understanding the background and clinical significance of the who, woah, and ema classifications of antimicrobials to mitigate antimicrobial resistance
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063873/
https://www.ncbi.nlm.nih.gov/pubmed/37008341
http://dx.doi.org/10.3389/fvets.2023.1153048
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