Advances in the development of antivirals for rotavirus infection

Rotavirus (RV) causes 200,000 deaths per year and imposes a serious burden to public health and livestock farming worldwide. Currently, rehydration (oral and intravenous) remains the main strategy for the treatment of rotavirus gastroenteritis (RVGE), and no specific drugs are available. This review...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Lin, Tang, Ao, Song, Lihua, Tong, Yigang, Fan, Huahao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063883/
https://www.ncbi.nlm.nih.gov/pubmed/37006293
http://dx.doi.org/10.3389/fimmu.2023.1041149
_version_ 1785017787724333056
author Jiang, Lin
Tang, Ao
Song, Lihua
Tong, Yigang
Fan, Huahao
author_facet Jiang, Lin
Tang, Ao
Song, Lihua
Tong, Yigang
Fan, Huahao
author_sort Jiang, Lin
collection PubMed
description Rotavirus (RV) causes 200,000 deaths per year and imposes a serious burden to public health and livestock farming worldwide. Currently, rehydration (oral and intravenous) remains the main strategy for the treatment of rotavirus gastroenteritis (RVGE), and no specific drugs are available. This review discusses the viral replication cycle in detail and outlines possible therapeutic approaches including immunotherapy, probiotic-assisted therapy, anti-enteric secretory drugs, Chinese medicine, and natural compounds. We present the latest advances in the field of rotavirus antivirals and highlights the potential use of Chinese medicine and natural compounds as therapeutic agents. This review provides an important reference for rotavirus prevention and treatment.
format Online
Article
Text
id pubmed-10063883
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-100638832023-04-01 Advances in the development of antivirals for rotavirus infection Jiang, Lin Tang, Ao Song, Lihua Tong, Yigang Fan, Huahao Front Immunol Immunology Rotavirus (RV) causes 200,000 deaths per year and imposes a serious burden to public health and livestock farming worldwide. Currently, rehydration (oral and intravenous) remains the main strategy for the treatment of rotavirus gastroenteritis (RVGE), and no specific drugs are available. This review discusses the viral replication cycle in detail and outlines possible therapeutic approaches including immunotherapy, probiotic-assisted therapy, anti-enteric secretory drugs, Chinese medicine, and natural compounds. We present the latest advances in the field of rotavirus antivirals and highlights the potential use of Chinese medicine and natural compounds as therapeutic agents. This review provides an important reference for rotavirus prevention and treatment. Frontiers Media S.A. 2023-03-17 /pmc/articles/PMC10063883/ /pubmed/37006293 http://dx.doi.org/10.3389/fimmu.2023.1041149 Text en Copyright © 2023 Jiang, Tang, Song, Tong and Fan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Jiang, Lin
Tang, Ao
Song, Lihua
Tong, Yigang
Fan, Huahao
Advances in the development of antivirals for rotavirus infection
title Advances in the development of antivirals for rotavirus infection
title_full Advances in the development of antivirals for rotavirus infection
title_fullStr Advances in the development of antivirals for rotavirus infection
title_full_unstemmed Advances in the development of antivirals for rotavirus infection
title_short Advances in the development of antivirals for rotavirus infection
title_sort advances in the development of antivirals for rotavirus infection
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063883/
https://www.ncbi.nlm.nih.gov/pubmed/37006293
http://dx.doi.org/10.3389/fimmu.2023.1041149
work_keys_str_mv AT jianglin advancesinthedevelopmentofantiviralsforrotavirusinfection
AT tangao advancesinthedevelopmentofantiviralsforrotavirusinfection
AT songlihua advancesinthedevelopmentofantiviralsforrotavirusinfection
AT tongyigang advancesinthedevelopmentofantiviralsforrotavirusinfection
AT fanhuahao advancesinthedevelopmentofantiviralsforrotavirusinfection

Ejemplares similares