Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation

BACKGROUND: The utilization of donation after circulatory death (DCD) hearts can enlarge the donor pool. However, DCD hearts suffer from serious ischemia/reperfusion injury (IRI). Recent studies found that the activation of NLRP3 inflammasome could play a significant role in organ IRI. Mcc950, which...

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Detalles Bibliográficos
Autores principales: Xu, Liwei, Zeng, Zifeng, Niu, Chuanjie, Liu, Deshen, Lin, Shaoyan, Liu, Xiu, Szabó, Gábor, Lu, Jun, Zheng, Shaoyi, Zhou, Pengyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063899/
https://www.ncbi.nlm.nih.gov/pubmed/37008319
http://dx.doi.org/10.3389/fcvm.2023.1126391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063899/
https://www.ncbi.nlm.nih.gov/pubmed/37008319
http://dx.doi.org/10.3389/fcvm.2023.1126391

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