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Human gut, breast, and oral microbiome in breast cancer: A systematic review and meta-analysis

INTRODUCTION: Dysbiosis characterises breast cancer through direct or indirect interference in a variety of biological pathways; therefore, specific microbial patterns and diversity may be a biomarker for the diagnosis and prognosis of breast cancer. However, there is still much to determine about t...

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Autores principales: Thu, May Soe, Chotirosniramit, Korn, Nopsopon, Tanawin, Hirankarn, Nattiya, Pongpirul, Krit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063924/
https://www.ncbi.nlm.nih.gov/pubmed/37007104
http://dx.doi.org/10.3389/fonc.2023.1144021
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author Thu, May Soe
Chotirosniramit, Korn
Nopsopon, Tanawin
Hirankarn, Nattiya
Pongpirul, Krit
author_facet Thu, May Soe
Chotirosniramit, Korn
Nopsopon, Tanawin
Hirankarn, Nattiya
Pongpirul, Krit
author_sort Thu, May Soe
collection PubMed
description INTRODUCTION: Dysbiosis characterises breast cancer through direct or indirect interference in a variety of biological pathways; therefore, specific microbial patterns and diversity may be a biomarker for the diagnosis and prognosis of breast cancer. However, there is still much to determine about the complex interplay of the gut microbiome and breast cancer. OBJECTIVE: This study aims to evaluate microbial alteration in breast cancer patients compared with control subjects, to explore intestine microbial modification from a range of different breast cancer treatments, and to identify the impact of microbiome patterns on the same treatment-receiving breast cancer patients. METHODS: A literature search was conducted using electronic databases such as PubMed, Embase, and the CENTRAL databases up to April 2021. The search was limited to adult women with breast cancer and the English language. The results were synthesised qualitatively and quantitatively using random-effects meta-analysis. RESULTS: A total of 33 articles from 32 studies were included in the review, representing 19 case-control, eight cohorts, and five nonrandomised intervention researches. The gut and breast bacterial species were elevated in the cases of breast tumours, a significant increase in Methylobacterium radiotolerans (p = 0.015), in compared with healthy breast tissue. Meta-analysis of different α-diversity indexes such as Shannon index (p = 0.0005), observed species (p = 0.006), and faint’s phylogenetic diversity (p < 0.00001) revealed the low intestinal microbial diversity in patients with breast cancer. The microbiota abundance pattern was identified in different sample types, detection methods, menopausal status, nationality, obesity, sleep quality, and several interventions using qualitative analysis. CONCLUSIONS: This systematic review elucidates the complex network of the microbiome, breast cancer, and therapeutic options, with the objective of providing a link for stronger research studies and towards personalised medicine to improve their quality of life.
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spelling pubmed-100639242023-04-01 Human gut, breast, and oral microbiome in breast cancer: A systematic review and meta-analysis Thu, May Soe Chotirosniramit, Korn Nopsopon, Tanawin Hirankarn, Nattiya Pongpirul, Krit Front Oncol Oncology INTRODUCTION: Dysbiosis characterises breast cancer through direct or indirect interference in a variety of biological pathways; therefore, specific microbial patterns and diversity may be a biomarker for the diagnosis and prognosis of breast cancer. However, there is still much to determine about the complex interplay of the gut microbiome and breast cancer. OBJECTIVE: This study aims to evaluate microbial alteration in breast cancer patients compared with control subjects, to explore intestine microbial modification from a range of different breast cancer treatments, and to identify the impact of microbiome patterns on the same treatment-receiving breast cancer patients. METHODS: A literature search was conducted using electronic databases such as PubMed, Embase, and the CENTRAL databases up to April 2021. The search was limited to adult women with breast cancer and the English language. The results were synthesised qualitatively and quantitatively using random-effects meta-analysis. RESULTS: A total of 33 articles from 32 studies were included in the review, representing 19 case-control, eight cohorts, and five nonrandomised intervention researches. The gut and breast bacterial species were elevated in the cases of breast tumours, a significant increase in Methylobacterium radiotolerans (p = 0.015), in compared with healthy breast tissue. Meta-analysis of different α-diversity indexes such as Shannon index (p = 0.0005), observed species (p = 0.006), and faint’s phylogenetic diversity (p < 0.00001) revealed the low intestinal microbial diversity in patients with breast cancer. The microbiota abundance pattern was identified in different sample types, detection methods, menopausal status, nationality, obesity, sleep quality, and several interventions using qualitative analysis. CONCLUSIONS: This systematic review elucidates the complex network of the microbiome, breast cancer, and therapeutic options, with the objective of providing a link for stronger research studies and towards personalised medicine to improve their quality of life. Frontiers Media S.A. 2023-03-17 /pmc/articles/PMC10063924/ /pubmed/37007104 http://dx.doi.org/10.3389/fonc.2023.1144021 Text en Copyright © 2023 Thu, Chotirosniramit, Nopsopon, Hirankarn and Pongpirul https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Thu, May Soe
Chotirosniramit, Korn
Nopsopon, Tanawin
Hirankarn, Nattiya
Pongpirul, Krit
Human gut, breast, and oral microbiome in breast cancer: A systematic review and meta-analysis
title Human gut, breast, and oral microbiome in breast cancer: A systematic review and meta-analysis
title_full Human gut, breast, and oral microbiome in breast cancer: A systematic review and meta-analysis
title_fullStr Human gut, breast, and oral microbiome in breast cancer: A systematic review and meta-analysis
title_full_unstemmed Human gut, breast, and oral microbiome in breast cancer: A systematic review and meta-analysis
title_short Human gut, breast, and oral microbiome in breast cancer: A systematic review and meta-analysis
title_sort human gut, breast, and oral microbiome in breast cancer: a systematic review and meta-analysis
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063924/
https://www.ncbi.nlm.nih.gov/pubmed/37007104
http://dx.doi.org/10.3389/fonc.2023.1144021
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