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Ion channels as molecular targets of glioblastoma electrotherapy

Therapies with weak, non-ionizing electromagnetic fields comprise FDA-approved treatments such as Tumor Treating Fields (TTFields) that are used for adjuvant therapy of glioblastoma. In vitro data and animal models suggest a variety of biological TTFields effects. In particular, effects ranging from...

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Autores principales: Abed, Tayeb, Ganser, Katrin, Eckert, Franziska, Stransky, Nicolai, Huber, Stephan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10064067/
https://www.ncbi.nlm.nih.gov/pubmed/37006466
http://dx.doi.org/10.3389/fncel.2023.1133984
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author Abed, Tayeb
Ganser, Katrin
Eckert, Franziska
Stransky, Nicolai
Huber, Stephan M.
author_facet Abed, Tayeb
Ganser, Katrin
Eckert, Franziska
Stransky, Nicolai
Huber, Stephan M.
author_sort Abed, Tayeb
collection PubMed
description Therapies with weak, non-ionizing electromagnetic fields comprise FDA-approved treatments such as Tumor Treating Fields (TTFields) that are used for adjuvant therapy of glioblastoma. In vitro data and animal models suggest a variety of biological TTFields effects. In particular, effects ranging from direct tumoricidal, radio- or chemotherapy-sensitizing, metastatic spread-inhibiting, up to immunostimulation have been described. Diverse underlying molecular mechanisms, such as dielectrophoresis of cellular compounds during cytokinesis, disturbing the formation of the spindle apparatus during mitosis, and perforating the plasma membrane have been proposed. Little attention, however, has been paid to molecular structures that are predestinated to percept electromagnetic fields—the voltage sensors of voltage-gated ion channels. The present review article briefly summarizes the mode of action of voltage sensing by ion channels. Moreover, it introduces into the perception of ultra-weak electric fields by specific organs of fishes with voltage-gated ion channels as key functional units therein. Finally, this article provides an overview of the published data on modulation of ion channel function by diverse external electromagnetic field protocols. Combined, these data strongly point to a function of voltage-gated ion channels as transducers between electricity and biology and, hence, to voltage-gated ion channels as primary targets of electrotherapy.
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spelling pubmed-100640672023-04-01 Ion channels as molecular targets of glioblastoma electrotherapy Abed, Tayeb Ganser, Katrin Eckert, Franziska Stransky, Nicolai Huber, Stephan M. Front Cell Neurosci Cellular Neuroscience Therapies with weak, non-ionizing electromagnetic fields comprise FDA-approved treatments such as Tumor Treating Fields (TTFields) that are used for adjuvant therapy of glioblastoma. In vitro data and animal models suggest a variety of biological TTFields effects. In particular, effects ranging from direct tumoricidal, radio- or chemotherapy-sensitizing, metastatic spread-inhibiting, up to immunostimulation have been described. Diverse underlying molecular mechanisms, such as dielectrophoresis of cellular compounds during cytokinesis, disturbing the formation of the spindle apparatus during mitosis, and perforating the plasma membrane have been proposed. Little attention, however, has been paid to molecular structures that are predestinated to percept electromagnetic fields—the voltage sensors of voltage-gated ion channels. The present review article briefly summarizes the mode of action of voltage sensing by ion channels. Moreover, it introduces into the perception of ultra-weak electric fields by specific organs of fishes with voltage-gated ion channels as key functional units therein. Finally, this article provides an overview of the published data on modulation of ion channel function by diverse external electromagnetic field protocols. Combined, these data strongly point to a function of voltage-gated ion channels as transducers between electricity and biology and, hence, to voltage-gated ion channels as primary targets of electrotherapy. Frontiers Media S.A. 2023-03-17 /pmc/articles/PMC10064067/ /pubmed/37006466 http://dx.doi.org/10.3389/fncel.2023.1133984 Text en Copyright © 2023 Abed, Ganser, Eckert, Stransky and Huber. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular Neuroscience
Abed, Tayeb
Ganser, Katrin
Eckert, Franziska
Stransky, Nicolai
Huber, Stephan M.
Ion channels as molecular targets of glioblastoma electrotherapy
title Ion channels as molecular targets of glioblastoma electrotherapy
title_full Ion channels as molecular targets of glioblastoma electrotherapy
title_fullStr Ion channels as molecular targets of glioblastoma electrotherapy
title_full_unstemmed Ion channels as molecular targets of glioblastoma electrotherapy
title_short Ion channels as molecular targets of glioblastoma electrotherapy
title_sort ion channels as molecular targets of glioblastoma electrotherapy
topic Cellular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10064067/
https://www.ncbi.nlm.nih.gov/pubmed/37006466
http://dx.doi.org/10.3389/fncel.2023.1133984
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AT stranskynicolai ionchannelsasmoleculartargetsofglioblastomaelectrotherapy
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