Takayasu’s Arteritis in Mexican Monozygotic Twins: Analysis of Human Leukocyte Antigens (HLA) Haplotypes

Takayasu’s arteritis (TA) is an idiopathic great vessel vasculitis that affects the aorta and its branches. This entity is associated with the major histocompatibility complex (MHC) genes. We studied DNA sequences of human leukocyte antigens (HLA) haplotypes in one pair of Mexican monozygotic twins...

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Autores principales: Hinojosa, Carlos A., Anaya-Ayala, Javier E., Laparra-Escareno, Hugo, Mena-Hernandez, Lourdes, Barquera, Rodrigo, Martínez-Quesada, Jose I., Granados, Julio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese College of Angiology / The Japanese Society for Vascular Surgery / Japanese Society of Phlebology 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10064293/
https://www.ncbi.nlm.nih.gov/pubmed/37006858
http://dx.doi.org/10.3400/avd.cr.22-00094
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author Hinojosa, Carlos A.
Anaya-Ayala, Javier E.
Laparra-Escareno, Hugo
Mena-Hernandez, Lourdes
Barquera, Rodrigo
Martínez-Quesada, Jose I.
Granados, Julio
author_facet Hinojosa, Carlos A.
Anaya-Ayala, Javier E.
Laparra-Escareno, Hugo
Mena-Hernandez, Lourdes
Barquera, Rodrigo
Martínez-Quesada, Jose I.
Granados, Julio
author_sort Hinojosa, Carlos A.
collection PubMed
description Takayasu’s arteritis (TA) is an idiopathic great vessel vasculitis that affects the aorta and its branches. This entity is associated with the major histocompatibility complex (MHC) genes. We studied DNA sequences of human leukocyte antigens (HLA) haplotypes in one pair of Mexican monozygotic twins affected by TA. HLA alleles were determined by sequence-specific priming. Genetic testing of the HLA haplotypes in both sisters were A*02 B*39 DRB1*04 DQB1*03 : 02/A*24 B*35 DRB1*16 DQB1*03 : 01. These results confirm that within the MHC are genes that determine genetic susceptibility to develop TA and sustain genetic heterogeneity of this disease among populations.
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spelling pubmed-100642932023-04-01 Takayasu’s Arteritis in Mexican Monozygotic Twins: Analysis of Human Leukocyte Antigens (HLA) Haplotypes Hinojosa, Carlos A. Anaya-Ayala, Javier E. Laparra-Escareno, Hugo Mena-Hernandez, Lourdes Barquera, Rodrigo Martínez-Quesada, Jose I. Granados, Julio Ann Vasc Dis Case Report Takayasu’s arteritis (TA) is an idiopathic great vessel vasculitis that affects the aorta and its branches. This entity is associated with the major histocompatibility complex (MHC) genes. We studied DNA sequences of human leukocyte antigens (HLA) haplotypes in one pair of Mexican monozygotic twins affected by TA. HLA alleles were determined by sequence-specific priming. Genetic testing of the HLA haplotypes in both sisters were A*02 B*39 DRB1*04 DQB1*03 : 02/A*24 B*35 DRB1*16 DQB1*03 : 01. These results confirm that within the MHC are genes that determine genetic susceptibility to develop TA and sustain genetic heterogeneity of this disease among populations. Japanese College of Angiology / The Japanese Society for Vascular Surgery / Japanese Society of Phlebology 2023-03-25 /pmc/articles/PMC10064293/ /pubmed/37006858 http://dx.doi.org/10.3400/avd.cr.22-00094 Text en © 2023 The Editorial Committee of Annals of Vascular Diseases. https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided the credit of the original work, a link to the license, and indication of any change are properly given, and the original work is not used for commercial purposes. Remixed or transformed contributions must be distributed under the same license as the original.
spellingShingle Case Report
Hinojosa, Carlos A.
Anaya-Ayala, Javier E.
Laparra-Escareno, Hugo
Mena-Hernandez, Lourdes
Barquera, Rodrigo
Martínez-Quesada, Jose I.
Granados, Julio
Takayasu’s Arteritis in Mexican Monozygotic Twins: Analysis of Human Leukocyte Antigens (HLA) Haplotypes
title Takayasu’s Arteritis in Mexican Monozygotic Twins: Analysis of Human Leukocyte Antigens (HLA) Haplotypes
title_full Takayasu’s Arteritis in Mexican Monozygotic Twins: Analysis of Human Leukocyte Antigens (HLA) Haplotypes
title_fullStr Takayasu’s Arteritis in Mexican Monozygotic Twins: Analysis of Human Leukocyte Antigens (HLA) Haplotypes
title_full_unstemmed Takayasu’s Arteritis in Mexican Monozygotic Twins: Analysis of Human Leukocyte Antigens (HLA) Haplotypes
title_short Takayasu’s Arteritis in Mexican Monozygotic Twins: Analysis of Human Leukocyte Antigens (HLA) Haplotypes
title_sort takayasu’s arteritis in mexican monozygotic twins: analysis of human leukocyte antigens (hla) haplotypes
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10064293/
https://www.ncbi.nlm.nih.gov/pubmed/37006858
http://dx.doi.org/10.3400/avd.cr.22-00094
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